Zobrazeno 1 - 10
of 24
pro vyhledávání: '"De‐en Xu"'
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 6-20 (2025)
The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic re
Externí odkaz:
https://doaj.org/article/eab50be41323444d9788007240dd08a8
Autor:
Ji-Chuan Liu, Xiu-Yun Zhao, Ming-Lei Wu, Yi-fan Shi, Ze-Ping Huang, Li-Pao Fang, Chao Zhu, Xuan Peng, Zi-Ling Shi, Li-Jun Lan, Wen-Li Ji, Li Luo, Lei Feng, Zeng-Li Zhang, De-en Xu, Shao Li, Zheng-Hong Qin, Yan-Yun Sun, Melitta Schachner, Quan-Hong Ma
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-17 (2024)
Abstract Neurons rely heavily on high mitochondrial metabolism to provide sufficient energy for proper development. However, it remains unclear how neurons maintain high oxidative phosphorylation (OXPHOS) during development. Mitophagy plays a pivotal
Externí odkaz:
https://doaj.org/article/a156d36b40004d2b8152d6ad79d8307b
Autor:
Yun-Yun Hu, Gang Yang, Xue-Song Liang, Xuan-Si Ding, De-En Xu, Zhe Li, Quan-Hong Ma, Rui Chen, Yan-Yun Sun
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Transcranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its good penetration
Externí odkaz:
https://doaj.org/article/0cb843ca6842418595e6a70fe5843a1c
Autor:
Yuan-Yuan Xie, Ting-Ting Pan, De-en Xu, Xin Huang, Yong Tang, Wenhui Huang, Rui Chen, Li Lu, Hao Chi, Quan-Hong Ma
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Disrupted myelin and impaired myelin repair have been observed in the brains of patients and various mouse models of Alzheimer’s disease (AD). Clemastine, an H1-antihistamine, shows the capability to induce oligodendrocyte precursor cell (OPC) diff
Externí odkaz:
https://doaj.org/article/3cd09cf14324471097898a1fc01a9ca0
Autor:
Mei-Hong Lu, Wen-Li Ji, Hong Chen, Yan-Yun Sun, Xiu-Yun Zhao, Fen Wang, Yi Shi, Yan-Ning Hu, Bo-Xiang Liu, Jing-wen Wu, De-En Xu, Jia-Wei Zheng, Chun-Feng Liu, Quan-Hong Ma
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory impairments, which has no effective therapy. Stem cell transplantation shows great potential in the therapy of various disease. However, the application of stem cell the
Externí odkaz:
https://doaj.org/article/2e184c9759804955bf4870eae6628a38
Autor:
Yan-Yun Sun, Wen-Jin Chen, Ze-Ping Huang, Gang Yang, Ming-Lei Wu, De-En Xu, Wu-Lin Yang, Yong-Chun Luo, Zhi-Cheng Xiao, Ru-Xiang Xu, Quan-Hong Ma
Publikováno v:
Cells, Vol 11, Iss 3, p 449 (2022)
Excitatory-inhibitory imbalance (E/I) is a fundamental mechanism underlying autism spectrum disorders (ASD). TRIM32 is a risk gene genetically associated with ASD. The absence of TRIM32 causes impaired generation of inhibitory GABAergic interneurons,
Externí odkaz:
https://doaj.org/article/b2061973abaf464dad7a7c376a2479cf
Autor:
Yan Zou, Wei-feng Zhang, Hai-ying Liu, Xia Li, Xing Zhang, Xiao-fang Ma, Yang Sun, Shi-yi Jiang, Quan-hong Ma, De-en Xu
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 9, Pp 1551-1558 (2017)
The contactin-associated protein (Caspr) family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family–CNTNAP1 (Caspr1), CNTNAP2 (Caspr2), CNTN
Externí odkaz:
https://doaj.org/article/2ff2643583db49b19773d465af197ff8
Autor:
Xiu-Yun Zhao, Mei-Hong Lu, De-Juan Yuan, De-En Xu, Pei-Pei Yao, Wen-Li Ji, Hong Chen, Wen-Long Liu, Chen-Xiao Yan, Yi-Yuan Xia, Shao Li, Jin Tao, Quan-Hong Ma
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, an
Externí odkaz:
https://doaj.org/article/7d8a18013bfc4381a4478160a94a11f4
Autor:
De‐Juan Yuan, Guang Yang, Wei Wu, Qi‐Fa Li, De‐en Xu, Michael Ntim, Chun‐Yan Jiang, Ji‐Chuan Liu, Yue Zhang, Ying‐Zi Wang, Dan‐Dan Zhu, Supratik Kundu, Ai‐Ping Li, Zhi‐Cheng Xiao, Quan‐Hong Ma, Shao Li
Publikováno v:
Aging cell. 21(5)
Aberrant increases in neuronal network excitability may contribute to cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons are not fully understood. Voltage-gated sodium channels (VGSC or Nav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ceaab49dbb6d5e04cef34daea3c864
https://pubmed.ncbi.nlm.nih.gov/35353937
https://pubmed.ncbi.nlm.nih.gov/35353937
Autor:
Xiu-Yun Zhao, Li-Hua Cheng, Ruxiang Xu, Pei-Pei Yao, Luigi Puglielli, De-En Xu, Ji-Bo Chen, Chun-Feng Liu, Ting-Hua Wang, Wen-Li Ji, Zhaotao Wang, Quan-Hong Ma, Rui Huang, Li-Pao Fang, Li-Jun Lan, Mei-Hong Lu
Publikováno v:
Experimental Neurology. 311:67-79
Sphingolipids emerge as essential modulators in the etiology of Alzheimer's disease (AD) with unclear mechanisms. Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c657b12ef7fcef17df0e0c81328e513a
https://doi.org/10.1016/j.expneurol.2018.09.012
https://doi.org/10.1016/j.expneurol.2018.09.012