Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer Treatment

Autor: Zhi-Ren Liu, Jenny J. Yang, Malvika Sharma, Shiyuan Wang, Falguni Mishra, Sun Li, Ravi Chakra Turaga, Alyssa M. Krasinskas, Yi Yuan, Chunfeng Liu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 161-179 (2021)

Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8771aab570fac7daa58c9d33c3452dcd
http://europepmc.org/articles/PMC7674520

Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases

Autor: Magnus Johansson, An R. Van Rompay, Anna Karlsson

Publikováno v: Pharmacology & Therapeutics

Structural analogues of nucleosides, nucleoside analogues (NA), are used in the treatment of cancer and viral infections. Antiviral NAs inhibit replication of the viral genome, whereas anticancer NAs inhibit cellular DNA replication and repair. NAs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6553b01b19365f4cfb9274d7c9b9b4ab
https://doi.org/10.1016/j.pharmthera.2003.07.001