Effect of dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: a biomathematical model

Autor: Gd, Thomas, Mj, Chappell, Pw, Dykes, Db, Ramsden, Kr, Godfrey, Jr, Ellis, Arthur Bradwell

Publikováno v: Europe PubMed Central

A mathematical model has been developed to determine the best approach to improving tumor targeting with antibody. The amount of antibody in the tumor (tumor content) and the tumor:normal tissue antibody concentration ratio (uptake ratio) were calcul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::268e98f88a052d8f04ede853ebc33a13
http://europepmc.org/abstract/med/2720683

Using Downgaze Palsy Progression Rate to Model Survival in Progressive Supranuclear Palsy-Richardson Syndrome.

Autor: Xie T; Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA., Wills AM; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Liao C; Biostatistics Laboratory, Department of Public Health Sciences, University of Chicago Medicine, Chicago, Illinois, USA., Dale ML; Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA., Ramsden DB; Institute of Metabolism and Systems Research of Medical School, University of Birmingham, Birmingham, United Kingdom., Padmanaban M; Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA., Abou Chaar W; Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA., Pantelyat A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Golbe LI; Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Publikováno v: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2023 Feb; Vol. 38 (2), pp. 304-312. Date of Electronic Publication: 2022 Dec 27.

Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects.

Autor: Ho PW; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong. hwl2002@hku.hk., Chang EE; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Leung CT; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Liu H; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Malki Y; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Pang SY; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Choi ZY; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Liang Y; Division of Respiratory Medicine, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Lai WS; Department of Chemistry, State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong., Ruan Y; Department of Chemistry, State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong., Leung KM; Department of Chemistry, State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong., Yung S; Division of Nephrology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Mak JC; Division of Respiratory Medicine, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Kung MH; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong., Ramsden DB; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom., Ho SL; Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong. slho@hku.hk.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2022 Sep 10; Vol. 8 (1), pp. 115. Date of Electronic Publication: 2022 Sep 10.

LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease.

Autor: Chang EES; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China., Ho PW; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China. hwl2002@hku.hk., Liu HF; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China., Pang SY; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China., Leung CT; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China., Malki Y; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China., Choi ZY; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China., Ramsden DB; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK., Ho SL; Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong, China. slho@hku.hk.

Publikováno v: Translational neurodegeneration [Transl Neurodegener] 2022 Feb 14; Vol. 11 (1), pp. 10. Date of Electronic Publication: 2022 Feb 14.

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 ^R1441G mice.

Autor: Liu H; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Ho PW; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Leung CT; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Pang SY; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Chang EES; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Choi ZY; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Kung MH; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China., Ramsden DB; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK., Ho SL; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China.

Publikováno v: Autophagy [Autophagy] 2021 Oct; Vol. 17 (10), pp. 3196-3220. Date of Electronic Publication: 2020 Dec 10.