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pro vyhledávání: '"Dazoxiben"'
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Autor:
Yongmei Zhang, Candice D. Fike, Mark R. Kaplowitz, Judy L. Aschner, James C. Slaughter, Sandra L. Pfister
Publikováno v:
Pediatric Research. 70:136-141
Reactive oxygen species (ROS) have been implicated in the pathogenesis of pulmonary hypertension. ROS might mediate vascular responses, at least in part, by stimulating prostanoid production. Our goals were to determine whether the effect of ROS on v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124e8d50a81c7961070b06b8e1c6bb9d
https://doi.org/10.1203/pdr.0b013e3182207ce7
https://doi.org/10.1203/pdr.0b013e3182207ce7
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H2064-H2071
This study explored the hypothesis that a portion of angiotensin II-induced contractions is dependent on superoxide generation and release of a previously unidentified arachidonic acid metabolite that activates vascular smooth muscle thromboxane rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8a8523de5bee009802f0584916b500
https://doi.org/10.1152/ajpheart.01135.2010
https://doi.org/10.1152/ajpheart.01135.2010
Publikováno v:
British Journal of Pharmacology. 150:624-632
Background and purpose: To study the importance of endothelium-derived contracting factors (EDCFs) in arteries of rats with type I diabetes. Experimental approach: Rat femoral arteries were collected four or twelve weeks after induction of diabetes w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ad8765860a35a6d1543926712844064
https://doi.org/10.1038/sj.bjp.0706999
https://doi.org/10.1038/sj.bjp.0706999
Publikováno v:
European Journal of Pharmacology. 556:107-114
In mature spontaneously hypertensive (SHR) and Wistar–Kyoto (WKY) rats, acetylcholine, the calcium ionophore A 23187 and ATP release endothelium-derived contracting factor (EDCF), cyclooxygenase (COX) derivatives that activate thromboxane–endoper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fac2d3b1f732c2751f9270f4549e4f7
https://doi.org/10.1016/j.ejphar.2006.10.050
https://doi.org/10.1016/j.ejphar.2006.10.050
Publikováno v:
British Journal of Pharmacology. 146:834-845
In the spontaneously hypertensive rat (SHR) and aging Wistar-Kyoto rats (WKY), acetylcholine releases an endothelium-derived contracting factor (EDCF) produced by endothelial cyclooxygenase-1, which stimulates thromboxane A2 receptors (TP receptors)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfba0128f6cd97db1df8e5a3cf90721a
https://doi.org/10.1038/sj.bjp.0706390
https://doi.org/10.1038/sj.bjp.0706390
Autor:
F. Sánchez de la Cuesta, A. Guerrero, J.P. De La Cruz, M. M. Arrebola, M.A. Villalobos, R Escalante
Publikováno v:
Pharmacology. 69:44-50
The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271f34da7e83580b3d33f859d2c4be10
https://doi.org/10.1159/000071266
https://doi.org/10.1159/000071266
Autor:
João B. Calixto, Mariem El Sayah
Publikováno v:
European Journal of Pharmacology. 458:175-181
This study was designed to investigate the mechanisms by which bradykinin induces contraction of the pig iris sphincter muscle in vitro. Addition of bradykinin, Lys-bradykinin and Met-Lys-bradykinin to the pig iris sphincter resulted in a graded cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e811d6494ed52307b37db926d9dadc7
https://doi.org/10.1016/s0014-2999(02)02702-4
https://doi.org/10.1016/s0014-2999(02)02702-4
Autor:
R Escalante, M. M. Arrebola, A. Guerrero, F. Sánchez de la Cuesta, J.P. De La Cruz, M.A. Villalobos
Publikováno v:
British Journal of Pharmacology. 137:1082-1088
Drugs that inhibit TxA2 synthesis are used to reduce platelet aggregation. The aim of this study was to compare the effects of a cyclo-oxygenase (COX) inhibitor (acetylsalicylic acid, ASA), a thromboxane synthetase (TxS) inhibitor (dazoxiben) and a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4568e2b68b108ff078c6e3991ed286b
https://doi.org/10.1038/sj.bjp.0704963
https://doi.org/10.1038/sj.bjp.0704963
Publikováno v:
Prostaglandins & Other Lipid Mediators. 70:39-49
Previous studies suggested that cultured human endothelial cells metabolize arachidonic acid to thromboxane A 2 . When primary cultures of human umbilical vein endothelial cells were incubated with 14 C -arachidonic acid and the 14 C -metabolites res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc673b4e41ba9ad440a67d87687fc7a5
https://doi.org/10.1016/s0090-6980(02)00009-6
https://doi.org/10.1016/s0090-6980(02)00009-6