Výsledky vyhledávání - "Dayton T. Meyer"

γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Autor: Sandhya Mandlekar, John V. Duncia, Joel C. Barrish, Robert J. Cherney, Joseph B. Santella, Yang Michael G, Carl P. Decicco, Matthew E. Voss, Mary Ellen Cvijic, Dayton T. Meyer, Yvonne C. Lo, Percy H. Carter, Ruowei Mo, Qihong Zhao, Persymphonie B. Miller, Peggy A. Scherle, Gengjie Yang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:2425-2430

We describe the design, synthesis, and evaluation, of γ-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2 antagonists. The lactam-containing trisubstituted cyclohexanes proved to be more potent than the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0c688f376f1d419e9dd35eb4d2c27b
https://doi.org/10.1016/j.bmcl.2010.03.035

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Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists

Autor: Peggy A. Scherle, Matthew E. Voss, Dayton T. Meyer, Persymphonie B. Miller, Gengjie Yang, Andrew J. Tebben, Yvonne C. Lo, Robert J. Cherney, Ruowei Mo, Carl P. Decicco, Percy H. Carter

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:3418-3422

Potent sulfone-containing di- and trisubstituted cyclohexanes were synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the trisubstituted derivative 54, which exhibited excellent binding (CCR2 IC(50)=1.3nM) and functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed77e3002730b2c6103129637963cb1
https://doi.org/10.1016/j.bmcl.2009.05.041

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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

Autor: Yvonne C. Lo, Carl P. Decicco, Dayton T. Meyer, Ruowei Mo, Sandhya Mandlekar, Percy H. Carter, Andrew J. Tebben, Kimberly A. Solomon, Gengjie Yang, David J. Nelson, Robert J. Cherney, Heather Jezak, Peggy A. Scherle, Zelda R. Wasserman

Publikováno v: Journal of Medicinal Chemistry. 51:721-724

We describe the design, synthesis, and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. Exploratory SAR studies led to the cis-disubstituted derivative 22, which displayed excellent binding affinity for CCR2 (binding IC50 =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6df9b94d3d438aeeb83f57b078c8d5
https://doi.org/10.1021/jm701488f

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Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Autor: James M. Trzaskos, Rui-Qin Liu, Elizabeth C. Arner, David D. Christ, Carl P. Decicco, Wenqing Yao, Robert J. Cherney, Maryanne B. Covington, Mingxin Qian, Robert C. Newton, Ron L Magolda, Dayton T. Meyer, Zelda R. Wasserman, Ruowei Mo, Micky D. Tortorella, Li Wang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:1297-1300

Anti-succinate hydroxamates with cyclic P1 motifs were synthesized as aggrecanase inhibitors. The N-methanesulfonyl piperidine 23 and the N-trifluoroacetyl azetidine 26 were the most potent aggrecanase inhibitors both having an IC50=3 nM while mainta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297fbc397746e76e53e9b9952620e792
https://doi.org/10.1016/s0960-894x(03)00124-0

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Corannulene. A Three-Step Synthesis1

Autor: Lawrence T. Scott, Mohammed M. Hashemi, Dayton T. Meyer, Pei-Chao Cheng, Hope B. Warren, Matthew S. Bratcher

Publikováno v: Journal of the American Chemical Society. 119:10963-10968

Thermal cyclization of 7,10-diethynylfluoranthene (3) in the gas phase gives corannulene (2), the smallest bowl-shaped polycyclic hydrocarbon fragment of C60 with fullerene-like curvature. Bromocorannulene (10) and 1,6-dibromocorannulene (9) have als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7467be8e5f9faabdd3fa13343b9acfa8
https://doi.org/10.1021/ja972019g

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Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

Autor: Carl P. Decicco, Li Wang, David J. Nelson, Dayton T. Meyer, Elizabeth C. Arner, Robert J. Cherney, Robert A. Copeland, Karl D. Hardman

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:1757-1762

Several carboxylate derivatives with variation at the P1′ residue were synthesized and evaluated as stromelysin (MMP-3) inhibitors. Compounds containing a biphenyl moiety at P1′ were found to be potent inhibitors of MMP-3. An X-ray crystal struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7d3bda6169c41b0a470236d40bf3502
https://doi.org/10.1016/s0960-894x(97)00308-9

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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Autor: Mary Ellen Cvijic, Joel C. Barrish, Robert J. Cherney, Carl P. Decicco, Persymphonie B. Miller, Gengjie Yang, Percy H. Carter, Yvonne C. Lo, Ruowei Mo, Anthony D. Pechulis, Dayton T. Meyer, Peggy A. Scherle, Qihong Zhao, Michael A. Guaciaro

Publikováno v: Bioorganicmedicinal chemistry letters. 22(19)

We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CCR2 antagonists. 7-Trifluoromethylbenzimidazoles displayed potent binding and functional antagonism of CCR2 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1ffc4f452ed95f33ad4ca051991812
https://pubmed.ncbi.nlm.nih.gov/22939233

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