Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Autor: Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Abstract Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rul

Externí odkaz: https://doaj.org/article/f49351239a2f427ab2056944955526c8

Correction to: Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Autor: Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Roslyn A. Hendriks, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via the original article.

Externí odkaz: https://doaj.org/article/d740ed64c3ac49a68c827986110142dc

Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Autor: Krupa Arun Navalkar, Brian A. Fox, Leo McHugh, Cristina Venturini, Antony Rapisarda, Thomas D. Yager, Eliza Gil, Evi Tsaliki, Roslyn A. Hendriks, Sian Stafford, Benjamin M. Chain, Mahdad Noursadeghi, Dayle Sampson, Laura Shallcross, Nandi Simpson, Jennifer K. Roe, Richard Bruce Brandon, Therese Seldon

Publikováno v: BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rule-out blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d0a54ebe429c461d3f68c506cb456e
https://doi.org/10.1186/s12916-020-01653-3

Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach

Autor: Jerry J. Zimmerman, Silvia Cermelli, Krupa Arun Navalkar, Lester C. Permut, Erin Sullivan, Therese Seldon, Dayle Sampson, Adrian M. Piliponsky, Nicholas J. Shubin, Thomas D. Yager

Publikováno v: Critical care medicine. 48(1)

Objectives Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d116777134af36ba6201332ce9e229a
https://pubmed.ncbi.nlm.nih.gov/31714400

Validation of a host response assay, SeptiCyte LAB, for discriminating sepsis from systemic inflammatory response syndrome in the ICU

Autor: Marcus J. Schultz, Greg S. Martin, Dayle Sampson, Thomas D. Yager, Robert A. Balk, Silvia Cermelli, Tom van der Poll, Stella Hahn, Richard E. Rothman, Antony Rapisarda, Annette M. Esper, Steven M. Opal, Jordan A. Kempker, Shruti Bhide, Brian A. Fox, Mitchell M. Levy, Richard Bruce Brandon, Roslyn A. Brandon, Neil R. Aggarwal, Adey Tsegaye, Krupa Arun Navalkar, Majid Afshar, Mark Yoder, Russell R. Miller, John P. Burke, Emily R. Gilbert, Paul H. Mayo, Victoria Rothwell, Franco R. D'Alessio, Gourang P. Patel, Therese Seldon, Venkataramana K. Sidhaye, Roy F. Davis, James T. Kirk, Brendon P. Scicluna, Mangala Narasimhan, Leo McHugh, Richard Newman, Bert K. Lopansri, Peter M. C. Klein Klouwenberg, Jared A. Greenberg, Jorge P. Parada

Publikováno v: American journal of respiratory and critical care medicine, 198(7), 903-913. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine

A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe86da10b4868ef23566cd09454be03
https://pure.amc.nl/en/publications/validation-of-a-host-response-assay-septicyte-lab-for-discriminating-sepsis-from-systemic-inflammatory-response-syndrome-in-the-icu(9afff7c3-7587-40bd-9dd1-e75e460d9c47).html