Human Scleral Diffusion of Anticancer Drugs from Solution and Nanoparticle Formulation

Autor: Rajendra S. Kadam, Sung Jin Lee, Chandrasekar Durairaj, E. S. Kim, Henry F. Edelhauser, Yun Mo, Uday B. Kompella, Dayle H. Geroski

Publikováno v: Pharmaceutical Research. 26:1155-1161

To determine the transscleral permeability of chemotherapeutic drugs vinblastine and doxorubicin for treatment of intraocular tumors, and to compare the use of doxorubicin encapsulated in PLGA and liposome nanoparticles.Human sclera was isolated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7dcfea11b0cebc5ad4989cc6b5d6c9
https://doi.org/10.1007/s11095-009-9835-0

Transscleral Permeability of Fluorescent-Labeled Antibiotics

Autor: Henry F. Edelhauser, Dayle H. Geroski, James C. Kao

Publikováno v: Journal of Ocular Pharmacology and Therapeutics. 21:1-10

To determine the in vitro transscleral permeability of antibiotics for posterior segment infection.Scleral sections from moist chamber-stored human globes were mounted in a 2-compartment perfusion chamber. Fluorescent-labeled vancomycin, polymyxin B,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fc94813560e9b0a43b0b595e9a249d
https://doi.org/10.1089/jop.2005.21.1

Measurement and Prediction of Transient Transport across Sclera for Drug Delivery to the Eye

Autor: Mark R. Prausnitz, David E. Rudnick, Aurélie Edwards, Jeremy S. Noonan, Dayle H. Geroski, Henry F. Edelhauser

Publikováno v: Industrial & Engineering Chemistry Research. 37:2903-2907

Drug delivery to the eye for treatment of a number of important diseases involves non-steady-state transport across the sclera. Although the literature contains steady-state measurements of permeability, the transient transport properties of sclera h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a27e27c02315b96cb83687276d91816
https://doi.org/10.1021/ie9800952

Corneal Endothelial Cytoskeletal Changes in F-Actin With Aging, Diabetes, and After Cytochalasin Exposure

Autor: Henry F. Edelhauser, Eung K. Kim, G.P. Holley, Steven I. Urken, Dayle H. Geroski

Publikováno v: American Journal of Ophthalmology. 114:329-335

We investigated the changes in endothelial cytoskeletal F-actin that occur with aging, diabetes, and exposure to cytochalasin D. Rabbit corneas, human donor corneas (with or without polymegethism), and corneas of diabetic individuals were studied. En

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb73cf38ca2a4f3f5a5a9783998911c
https://doi.org/10.1016/s0002-9394(14)71800-8

LIST OF CONTRIBUTORS

Autor: Juan C. Abad, Richard L. Abbott, Omar Ahmad, Tracy L. Aigner, Esen Karamürsel Akpek, Daniel M. Albert, Dimitri T. Azar, Siamak Balali, Neal P. Barney, Ashley Behrens, Marial D. Bernal, Robert E. Brass, Erich H.P. Braun, Geoffrey Brent, Frederick S. Brightbill, Linda L. Burk, Cat N. Burkat, Timothy B. Cavanaugh, Daniel H. Chang, Edwin S. Chen, Min Chen, Jesse Chew, Christopher Y. Chow, Roy S. Chuck, Robert J. Cionni, Liane Clamen, Glenn C. Cockerham, Carole A. Cooke, Douglas J. Coster, Constance Cox, Marc R. Criden, Matthew Alan Dahlgren, Daniel Dawson, Sheraz M. Daya, Ali R. Djalilian, John F. Doane, Murat Dogru, Terence J. Doherty, Claes H. Dohlman, Eric D. Donnenfeld, Peter C. Donshik, Steven P. Dunn, William J. Dupps, Henry Edelhauser, William Ehlers, Marcela Espinosa-Lagana, Jason Evangelista, Ella G. Faktorovich, Samir G. Farah, Marjan Farid, Ayad A. Farjo, Qais Anastas Farjo, M. Elizabeth Fini, Jerry G. Ford, C. Stephen Foster, Bradley Fouraker, Pierre Fournié, Prashant Garg, Dayle H. Geroski, Matthew Giegengack, Steven Paul Ginsberg, David B. Glasser, Michael Gordon, Gabriel M. Gordon, Mark S. Gorovoy, John D. Gottsch, Colin R. Green, David H. Haight, Julia A. Haller, Samer Hamada, David R. Hardten, Scott G. Hauswirth, David G. Heidemann, Lisa Herrygers, Natasha L. Herz, Christopher Hodge, Kenneth J. Hoffer, Edward J. Holland, Randolph T. Jackson, Frank M. Jakobs, Thomas John, Albert S. Jun, Alon Kahana, Andrea Cotait Kara-Jose, Steven E. Katz, Stephen D. Klyce, Douglas D. Koch, Ernest W. Kornmehl, Jay H. Krachmer, Amol D. Kulkarni, Peter R. Laibson, Ronald A. Laing, Jeffrey Day Lanier, Jonathan H. Lass, Michael A. Lawless, Dolena R. Ledee, James Lee, Janet Lee, Yunhee Lee, Kaevalin Lekhanont, Richard G. Lembach, Jeremy E. Levenson, Ilya M. Leyngold, Thomas J. Liesegang, Thomas D. Lindquist, Richard L. Lindstrom, Mark J. Lucarelli, Tina C. Lucas-Glass, Marian S. Macsai, Waleed Mahran, Fabrice Manns, Suy Anne R. Martins, William D. Mathers, Peter J. McDonnell, Charles N.J. McGhee, David M. Meisler, Shahzad Mian, H. L. Rick Milne, Bartly J. Mondino, W. Stanley Muenzler, Nariman Nassiri, Sarah Nehls, Catherine Newton, Guillermo E. Noguera, Michael L. Nordlund, Yuri S. Oleynikov, Randall J. Olson, Tania M. Onclinx, Tatsuya Ongucci, Tetsuro Oshika, Vasudha A. Panday, Sanjay V. Patel, Jay S. Pepose, Daryl R. Pfister, Roswell R. Pfister, Heather Anne Delong Potter, Gaurav Prakash, Marianne O. Price, Francis W. Price, Louis E. Probst, Mujtaba A. Qazi, Gullapalli N. Rao, Christopher J. Rapuano, Satya V. Reddy, John William Reed, William J. Reinhart, Cynthia J. Roberts, Linda Rose, Steven Rosenfeld, Jason S. Rothman, James Rowsey, Roy Scott Rubinfeld, David J. Schanzlin, Olivia N. Serdarevic, Neda Shamie, Namrata Sharma, Edward Shaw, Trevor Sherwin, Shigeto Shimmura, Christine Sindt, Stephen Slade, Renée Solomon, Kaz Soong, Walter J. Stark, Roger F. Steinert, Joel Sugar, Alan Sugar, Leejee H. Suh, John E. Sutphin, Mark A. Terry, Matthew Joseph Thompson, Kazuo Tsubota, Elmer Y. Tu, Rasik B. Vajpayee, Mitul R. Vakharia, Jeremy Van Buren, Woodford S. Van Meter, David W. Vastine, Steven M. Verity, Elizabeth C.L. Vito, Hormuz P. Wadia, Michael D. Wagoner, Stephen G. Waller, Li Wang, George O. Waring, Liliana Werner, Bonnie C. Weston, Catherine E. Wheeldon, Keryn A. Williams, John Williams, Eric Y. Yoon, Gerald W. Zaidman, Christopher I. Zoumalan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df9c00bc073fba53689529f4d2b3da14
https://doi.org/10.1016/b978-0-323-04835-4.50004-5