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Akademický článek

Phenotypic and genotypic characterisation of Lactobacillus and yeast isolates from a traditional New Zealand Māori potato starter culture

Autor: Jia Sun, Olin Silander, Kay Rutherfurd-Markwick, Daying Wen, Tanya Poi-poi Davy, Anthony N. Mutukumira

Publikováno v: Current Research in Food Science, Vol 5, Iss , Pp 1287-1294 (2022)

Parāroa Rēwena is a traditional Māori sourdough produced by fermentation using a potato starter culture. The microbial composition of the starter culture is not well characterised, despite the long history of this product. The morphological, physi

Externí odkaz: https://doaj.org/article/5957906f88e1474786f79c1834fbfc58

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Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target

Autor: Nicole J. Moreland, Wai Yee Phong, Prasad N. Paradkar, Subhash G. Vasudevan, Daying Wen, Siew Pheng Lim

Publikováno v: Bioscience Reports. 31:399-409

Flaviviral NS3 serine proteases require the NS2B cofactor region (cNS2B) to be active. Recent crystal structures of WNV (West Nile virus) protease in complex with inhibitors revealed that cNS2B participates in the formation of the protease active sit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2817e5eea39ea0f273b7d1a613090d89
https://doi.org/10.1042/bsr20100142

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A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution

Autor: T. Xu, Thai Leong Yap, Julien Lescar, Daying Wen, Subhash G. Vasudevan, Yen Liang Chen

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 63:78-83

Dengue virus, a member of the Flaviviridae genus, causes dengue fever, an important emerging disease with several million infections occurring annually for which no effective therapy exists. The viral RNA-dependent RNA polymerase NS5 plays an importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b9f2dafa0518588267cbf56e560896
https://doi.org/10.1107/s1744309106055084

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Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 Å

Autor: T. Xu, Alex Chao, Daying Wen, Subhash G. Vasudevan, Julien Lescar, Max H. Nanao, Aruna Sampath, Patrick Chène

Publikováno v: Journal of Virology. 79:10278-10288

Dengue fever is an important emerging public health concern, with several million viral infections occurring annually, for which no effective therapy currently exists. The NS3 protein from Dengue virus is a multifunctional protein of 69 kDa, endowed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707041903bb5b52e43465ced7c024314
https://doi.org/10.1128/jvi.79.16.10278-10288.2005

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Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries

Autor: Jun Li, Christine Tumanut, Jennifer A. Williams, John P. Priestle, Subhash G. Vasudevan, Daying Wen, David C. Tully, Jennifer L. Harris, David Beer, Viral Patel, Siew Pheng Lim, Jiricek Jan

Publikováno v: Journal of Biological Chemistry. 280:28766-28774

Regulated proteolysis by the two-component NS2B/NS3 protease of dengue virus is essential for virus replication and the maturation of infectious virions. The functional similarity between the NS2B/NS3 proteases from the four genetically and antigenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84332b3398af4a40a4f6f21725f4507a
https://doi.org/10.1074/jbc.m500588200

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Expression, purification, crystallization, and preliminary X-ray analysis of the N-terminal domain of Escherichia coli adenylyl transferase

Autor: Yibin Xu, David L. Ollis, Paula Clancy, Paul D. Carr, Subhash G. Vasudevan, Daying Wen

Publikováno v: Protein Expression and Purification. 34:142-146

A soluble N-terminal domain of the Escherichia coli adenylyl transferase (ATase) is responsible for deadenylylation activity of the intact enzyme. Previous studies of the deadenylylation activity have involved a fragment, AT-N423 (residues 1 to 423),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a39649445ad301c06154933912a189d
https://doi.org/10.1016/j.pep.2003.11.001

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The Escherichia coli signal transducers PII (GlnB) and GlnK form heteromers in vivo: fine tuning the nitrogen siganl cascade

Autor: David L. Ollis, Paula Clancy, Rene Jaggi, Hans V. Westerhoff, Wally C. van Heeswijk, Subhash G. Vasudevan, Daying Wen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 97, 3942-3947. National Acad Sciences
van Heeswijk, W C, Wen, D, Clancy, P, Westerhoff, H V & Vasudevan, S G 2000, ' The Escherichia coli signal transducers PII (GlnB) and GlnK form heteromers in vivo: fine tuning the nitrogen siganl cascade. ', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, pp. 3942-3947 . https://doi.org/10.1073/pnas.97.8.3942

The PII protein is Escherichia coli 's cognate transducer of the nitrogen signal to the NRII (NtrB)/NRI (NtrC) two-component system and to adenylyltransferase. Through these two routes, PII regulates both amount and activity of glutamine synthetase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8da90cfc52c7457fd75b80c3c41e78e
https://hdl.handle.net/1871/20629

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Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size

Autor: Peng Sun, Deborah Young, Linzi Qiao, Maggie L. Kalev-Zylinska, Daying Wen, Wymond Symes, Kevin C. E. Little, Matthew J. During, P. Alan Barber

Publikováno v: Stroke. 44(8)

Background and Purpose— Antibodies against neuronal antigens develop in patients after stroke and some may serve as biomarkers of neuronal injury. We aimed to determine whether antibodies against subunit 1 (GluN1) of the N -methyl- d -aspartate rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255155cbc2b9804c1c76820a430dcd3e
https://pubmed.ncbi.nlm.nih.gov/23723305

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Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid

Autor: Marco Scarsi, Paul C. Sanschagrin, Michael Podvinec, Peter S. Shenkin, Siew Pheng Lim, Daying Wen, Torsten Schwede, Louis-Sebastian Sonntag, Tobias Schmidt

Publikováno v: Journal of medicinal chemistry. 53(4)

Dengue fever is a viral disease that affects 50-100 million people annually and is one of the most important emerging infectious diseases in many areas of the world. Currently, neither specific drugs nor vaccines are available. Here, we report on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f912dc6b558bdb09bd980f44fc0bffef
https://pubmed.ncbi.nlm.nih.gov/20108931

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A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease

Autor: Lijian Yap, Julien Lescar, Xun-Cheng Su, Danzhi Huang, Subhash G. Vasudevan, Siew Pheng Lim, Amedeo Caflisch, Gottfried Otting, Kiyoshi Ozawa, David Beer, Thomas H. Keller, Yin Hoe Yau, Daying Wen, Christophe Bodenreider, Sebastian Sonntag, Ting Zhou, Susana Geifman Shochat

Publikováno v: Analytical biochemistry. 395(2)

In drug discovery, the occurrence of false positives is a major hurdle in the search for lead compounds that can be developed into drugs. A small-molecular-weight compound that inhibits dengue virus protease at low micromolar levels was identified in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3930ec2ed1bfe619cabe9fe6595759ce
https://pubmed.ncbi.nlm.nih.gov/19682971

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