Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dayadevi Jirage"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3863-3867
Cyclin dependent protein kinases (CDKs) are pursued as drug targets for several eukaryotic pathogens. In this study, we identified thiophene and benzene sulfonamides as potent inhibitors of Pfmrk, a Plasmodium falciparum CDK with sequence homology to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e8a3e97012096d69da01cfcdf6263c
https://doi.org/10.1016/j.bmcl.2010.05.039
https://doi.org/10.1016/j.bmcl.2010.05.039
Autor:
Michael T. O’Neil, Diana Caridha, Fredrick Eyase, Yueqin Chen, Dayadevi Jirage, Norman C. Waters, Choukri Ben Mamoun, William H. Witola
Publikováno v:
Molecular and Biochemical Parasitology. 172:9-18
Cyclin-dependent kinases (CDKs) have an established role in metazoans and yeast in DNA replication, transcription and cell cycle regulation. Several CDKs and their effectors have been identified in the malaria parasite Plasmodium falciparum and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1f32824fefe017984805e327392e27
https://doi.org/10.1016/j.molbiopara.2010.03.009
https://doi.org/10.1016/j.molbiopara.2010.03.009
Publikováno v:
Infectious disorders drug targets. 10(3)
Protein kinases are pursued drug targets in numerous diseases including parasitic infections such as malaria. Plasmodium falciparum, the deadliest malarial parasite, relies on numerous protein kinases to regulate growth and differentiation through a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c78e601b67fe7a9ab61afb0b06dbca0
https://pubmed.ncbi.nlm.nih.gov/20334624
https://pubmed.ncbi.nlm.nih.gov/20334624
Publikováno v:
Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f75b6d56007e07a6c046dc979ad016
https://doi.org/10.1002/9783527626816.ch14
https://doi.org/10.1002/9783527626816.ch14
Autor:
Jeanne A. Geyer, Sean T. Prigge, Diana Caridha, Edison A. Cortes, Dayadevi Jirage, April K. Kathcart, Richard A. Dennull, Yueqin Chen, Norman C. Waters
Publikováno v:
Molecular and biochemical parasitology. 149(1)
Cyclin-dependent protein kinases (CDKs) are key regulators of cell cycle control. In humans, CDK7 performs dual roles as the CDK activating kinase (CAK) responsible for regulating numerous CDKs and as the RNA polymerase II carboxyl-terminal domain (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7224fdb9b894c3e13594c1e199a40dae
https://pubmed.ncbi.nlm.nih.gov/16737745
https://pubmed.ncbi.nlm.nih.gov/16737745
Publikováno v:
The Plant journal : for cell and molecular biology. 26(4)
Salicylic acid (SA)-dependent signaling controls activation of a set of plant defense mechanisms that are important for resistance to a variety of microbial pathogens. Many Arabidopsis mutants that display altered SA-dependent signaling have been iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd948221f4f7bde373e2783068b50e3b
https://pubmed.ncbi.nlm.nih.gov/11439127
https://pubmed.ncbi.nlm.nih.gov/11439127