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Adult height, coronary heart disease and stroke : A multi-locus Mendelian randomization meta-analysis

Autor: Nüesch, Eveline, Dale, Caroline, Palmer, Tom M., White, Jon, Keating, Brendan J., van Iperen, Erik P A, Goel, Anuj, Padmanabhan, Sandosh, Asselbergs, F. W., Verschuren, W. M., Wijmenga, C., Van der Schouw, Y. T., Onland-Moret, N. C., Lange, Leslie A., Hovingh, G. K., Sivapalaratnam, Suthesh, Morris, Richard W., Whincup, Peter H., Wannamethe, Goya S., Gaunt, Tom R., Ebrahim, Shah, Steel, Laura, Nair, Nikhil, Reiner, Alexander P., Kooperberg, Charles, Wilson, James F., Bolton, Jennifer L., McLachlan, Stela, Price, Jacqueline F., Strachan, Mark W J, Robertson, Christine M., Kleber, Marcus E., Delgado, Graciela, März, Winfried, Melander, Olle, Dominiczak, Anna F., Farrall, Martin, Watkins, Hugh, Leusink, Maarten, Maitland-van der Zee, Anke H., de Groot, Mark C H, Dudbridge, Frank, Hingorani, Aroon, Ben-Shlomo, Yoav, Lawlor, Debbie A., Amuzu, A., Caufield, M., Cavadino, A., Cooper, J., Davies, T. L., Day, I. N., Drenos, F., Engmann, J., Finan, C., Giambartolomei, C., Hardy, R., Humphries, S. E., Hypponen, E., Kivimaki, M., Kuh, D., Kumari, M., Ong, K., Plagnol, V., Power, C., Richards, M., Shah, S., Shah, T., Sofat, R., Talmud, P. J., Wareham, N., Warren, H., Whittaker, J. C., Wong, A., Zabaneh, D., Smith, George Davey, Wells, Jonathan C., Leon, David A., Holmes, Michael V., Casas, Juan P.

Publikováno v: International Journal of Epidemiology, 45(6), 1927. Oxford University Press

© The Author 2015; all rights reserved. Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f0112c7e185d039dfc19dd0c6244ba0
https://dspace.library.uu.nl/handle/1874/332756

Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals

Autor: Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., Fairfax, B. P., Elbers, C. C., Barnard, J., Farrall, M., Padmanabhan, S., Baumert, J., Castillo, B. A., Gaunt, T. R., Gong, Y., Rajagopalan, R., Romaine, S. P., Kumari, M., Rafelt, S., Smith, E. N., Li, Y. R., Sivapalaratnam, S., van Iperen, E. P., Speliotes, E. K., Toskala, E., Zhang, L., Ochs-Balcom, H. M., Bhangale, T. R., Chandrupatla, H. R., Drenos, F., Gieger, C., Gupta, J., Johnson, T., Kleber, M. E., Makino, S., Mangino, M., Meng, Y., Nelson, C. P., Pankow, J. S., Pankratz, N., Price, T. S., Shaffer, J., Shen, H., Tischfield, S., Tomaszewski, M., Atwood, L. D., Bailey, K. M., Balasubramanyam, A., Baldwin, C. T., Basart, H., Bauer, F., Behr, E. R., Beitelshees, A. L., Berenson, G. S., Beresford, S. A., Bezzina, C. R., Bhatt, D. L., Boer, J. M., Braund, P. S., Burke, G. L., Burkley, B., Carty, C., Chen, W., Clarke, R., Cooper-DeHoff, R. M., Curtis, S. P., de Bakker, P. I., de Jong, J. S., Delles, C., Dominiczak, A. F., Duggan, D., Feldman, H. I., Furlong, C. E., Gorski, M. M., Gums, J. G., Hardwick, R., Hastie, C., Heid, I. M., Huang, G.-H., Huggins, G. S., Humphries, S. E., Kirkland, S. A., Kivimaki, M., Klein, R., Klein, B. E., Knowler, W. C., Kottke-Marchant, K., LaCroix, A. Z., Langaee, T. Y., Li, M., Lyon, H. N., Maiwald, S., Marshall, J. K., Mehta, A., Meijs, M. F., Melander, O., Meyer, N., Mitra, N., Molony, C. M., Morrow, D. A., Murugesan, G., Newhouse, S. J., Nieto, J. F., Onland-Moret, N. C., Ouwehand, W. H., Palmen, J., Pepine, C. J., Ranchalis, J., Rosas, S. E., Rosenthal, E. A., Scharnagl, H., Schork, N. J., Schreiner, P. J., Shah, T., Shashaty, M., Shimbo, D., Srinivasan, S. R., Thomas, F., Tobin, M. D., Tsai, M. Y., Verschuren, W. M. M., Wagenknecht, L. E., Winkelmann, B. R., Young, T., Yusuf, S., Zafarmand, M. H., Zmuda, J. M., Zwinderman, A. H., Anand, S. S., Balmforth, A. J., Boehm, B. O., Boerwinkle, E., Burton, P. R., Cappola, T. P., Casas, J. P., Caulfield, M. J., Christiani, D. C., Christie, J., Cruickshanks, K. J., Davey-Smith, G., Davidson, K. W., Day, I. N., Doevendans, P. A., Dorn, G. W., FitzGerald, G. A., Hall, A. S., Hingorani, A. D., Hirschhorn, J. N., Hofker, M. H., Hovingh, K. G., Illig, T., Jamshidi, Y., Jarvik, G. P., Johnson, J. A., Kanetsky, P. A., Kastelein, J. J., Koenig, W., Lawlor, D. A., Marz, W., McCaffery, J., Mega, J. L., Mitchell, B. D., Murray, S. S., O'Connell, J. R., Patel, S. R., Peters, A., Pettinger, M., Rader, D. J., Redline, S., Reilly, M. P., Sabatine, M. S., Schadt, E. E., Shuldiner, A. R., Silverstein, R. L., Spector, T. D., Taylor, H. A., Thorand, B., Trip, M. D., Watkins, H., Wichmann, H.- E., Fox, C. S., Grant, S. F., Peter, I., Talmud, P. J., Munroe, P. B., Wilson, J. G., Knight, J. C., Samani, N. J., Hegele, R. A., Asselbergs, F. W., Monda, K. L., van der Schouw, Y. T., Demerath, E. W., Wijmenga, C., Timpson, N. J., Reiner, A. P., North, K. E., Papanicolaou, G. J., Lange , L. A., Keating , B. J.

Publikováno v: Human molecular genetics, 22(1), 184-201. Oxford University Press
Human Molecular Genetics
Hum. Mol. Genet. 22, 184-201 (2013)
Human Molecular Genetics; Vol 22

Recent genetic association studies have made progress in uncovering components of the genetic architecture of the body mass index (BMI). We used the ITMAT-Broad-Candidate Gene Association Resource (CARe) (IBC) array comprising up to 49 320 single nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0166578e352d396224c5a804613eb43e
https://pure.amc.nl/en/publications/genecentric-metaanalyses-of-108-912-individuals-confirm-known-body-mass-index-loci-and-reveal-three-novel-signals(cfdf63d4-bd63-48df-a043-b47d1a307f9f).html

PARL Leu262Val is not associated with fasting insulin levels in UK populations

Autor: Fawcett, K. A., Barroso, I., Wareham, N. J., Luan, J., Syddall, H., Cooper, C., O'Rahilly, S., Day, I. N. M., Sandhu, M. S.

Publikováno v: Diabetologia. 49(11)

AIMS/HYPOTHESIS: PARL, the gene encoding presenilins-associated rhomboid-like protein, maps to chromosome 3q27 within a quantitative trait locus that influences components of the metabolic syndrome. Recently, an amino acid substitution (Leu262Val, rs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732a171cea37ef10f88a4ca88c896a03
http://ora.ox.ac.uk/objects/uuid:bfebad30-cba9-4965-9972-bcb5e5dd79de

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