Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Dax A. Hoffman"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Proteins usually form complexes to fulfill variable physiological functions. In neurons, communication relies on synapses where receptors, channels, and anchoring proteins form complexes to precisely control signal transduction, synaptic integration,
Externí odkaz:
https://doaj.org/article/978b0b7d1ca74ca1989579d115dcee2b
Publikováno v:
Biophysical Reports, Vol 2, Iss 4, Pp 100082- (2022)
Neuronal function requires continuous distribution of ion channels and other proteins throughout large cell morphologies. Protein distribution is complicated by immobilization of freely diffusing subunits such as on lipid rafts or in postsynaptic den
Externí odkaz:
https://doaj.org/article/31a259ee3d3f47eda03b9f68eac2b72f
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105887- (2022)
We have previously reported that the single transmembrane protein Dipeptidyl Peptidase Like 6 (DPP6) impacts neuronal and synaptic development. DPP6-KO mice are impaired in hippocampal-dependent learning and memory and exhibit smaller brain size. Rec
Externí odkaz:
https://doaj.org/article/b4f84f46796d4dd692ba14fff8f8f3ce
Autor:
Jia–Hua Hu, Cole Malloy, G. Travis Tabor, Jakob J. Gutzmann, Ying Liu, Daniel Abebe, Rose-Marie Karlsson, Stewart Durell, Heather A. Cameron, Dax A. Hoffman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
K + channels function in macromolecular complexes with accessory subunits to regulate neuronal function. Here, the authors describe Pin1-mediated regulation of the Kv4.2 complex, which impacts reversal learning in mice, providing potential treatment
Externí odkaz:
https://doaj.org/article/20f42c6bb9064954b802b0b51ea31094
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9184 (2022)
The concerted action of voltage-gated ion channels in the brain is fundamental in controlling neuronal physiology and circuit function. Ion channels often associate in multi-protein complexes together with auxiliary subunits, which can strongly influ
Externí odkaz:
https://doaj.org/article/a323068f28a2453ab76fc4b5c9cdc7bf
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 h
Externí odkaz:
https://doaj.org/article/dded100dd42e4d6cbed372ba3ad0405c
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5921 (2020)
The subthreshold, transient A-type K+ current is a vital regulator of the excitability of neurons throughout the brain. In mammalian hippocampal pyramidal neurons, this current is carried primarily by ion channels comprising Kv4.2 α-subunits. These
Externí odkaz:
https://doaj.org/article/19b8062c56e74f4f97a404f4dc249372
Autor:
Lin Lin, Jonathan G. Murphy, Rose-Marie Karlsson, Ronald S. Petralia, Jakob J. Gutzmann, Daniel Abebe, Ya-Xian Wang, Heather A. Cameron, Dax A. Hoffman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
DPP6 is well known as an auxiliary subunit of Kv4-containing, A-type K+ channels which regulate dendritic excitability in hippocampal CA1 pyramidal neurons. We have recently reported, however, a novel role for DPP6 in regulating dendritic filopodia f
Externí odkaz:
https://doaj.org/article/05a6499f4fe14158879ccafb343662c3
Neuronal co-expression of EGFP and β-galactosidase in mice causes neuropathology and premature death
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 2, Pp 310-318 (2004)
Dose-dependent co-expression of enhanced green fluorescent protein (EGFP) and β-galactosidase (β-gal) in the cytoplasm of forebrain neurons of two independent mouse lines resulted in growth retardation, weakness, and premature lethality. In primary
Externí odkaz:
https://doaj.org/article/347fa20ef37c486bb9153960774d5558
Publikováno v:
Mol Cell Neurosci
Kv4.2 voltage-gated K(+) channel subunits, the primary source of the somatodendritic A-type K(+) current in CA1 pyramidal neurons of the hippocampus, play important roles in regulating dendritic excitability and plasticity. To better study the traffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a46dfbd88897476fe334fcecd70735
https://doi.org/10.1016/j.mcn.2019.06.007
https://doi.org/10.1016/j.mcn.2019.06.007