Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dawoud Sulaiman"'
Autor:
Dawoud Sulaiman, Dongyuan Wu, Lauren Page Black, Kevin J. Williams, Kiley Graim, Susmita Datta, Srinivasa T. Reddy, Faheem W. Guirgis
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract The purpose of this study was to investigate changes in the lipidome of patients with sepsis to identify signaling lipids associated with poor outcomes that could be linked to future therapies. Adult patients with sepsis were enrolled within
Externí odkaz:
https://doaj.org/article/34b08e111f7b43588b4cdc74d3788069
Autor:
Faheem W. Guirgis, MD, Vinitha Jacob, MD, PhD, Dongyuan Wu, MS, Morgan Henson, MPH, Kimberly Daly-Crews, BS, MS, Charlotte Hopson, MS, Lauren Page Black, MD, MPH, Elizabeth L. DeVos, MD, MPH, Dawoud Sulaiman, PhD, Guillaume Labilloy, MS, Todd M. Brusko, PhD, Jordan A. Shavit, MD, PhD, Andrew Bertrand, BS, Matthew Feldhammer, PhD, Brett Baskovich, MD, Kiley Graim, PhD, Susmita Datta, PhD, Srinivasa T. Reddy, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 6, p e0929 (2023)
IMPORTANCE:. This is a study of lipid metabolic gene expression patterns to discover precision medicine for sepsis. OBJECTIVES:. Sepsis patients experience poor outcomes including chronic critical illness (CCI) or early death (within 14 d). We invest
Externí odkaz:
https://doaj.org/article/fd6d22cc5aab4a2aa1801b53b447a5a7
Autor:
Arnab Chattopadhyay, Pallavi Mukherjee, Dawoud Sulaiman, Huan Wang, Victor Girjalva, Nasrin Dorreh, Jonathan P. Jacobs, Samuel Delk, Wouter H. Moolenaar, Mohamad Navab, Srinivasa T. Reddy, Alan M. Fogelman
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100370- (2023)
Conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA) by autotaxin, a secreted phospholipase D, is a major pathway for producing LPA. We previously reported that feeding Ldlr−/− mice standard mouse chow supplemented with unsaturate
Externí odkaz:
https://doaj.org/article/c456bf32fd6f45f5a462ebc2070084da
Autor:
Dawoud Sulaiman, Leo Sungwong Choi, Hyeong Min Lee, Jaejin Shin, Dong Hwan Kim, Keun Woo Lee, Pierre Eftekhari, Angélique Quartier, Hyung Soon Park, Srinivasa T. Reddy
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 687 (2023)
Vutiglabridin is a clinical-stage synthetic small molecule that is being developed for the treatment of obesity and its target proteins have not been fully identified. Paraoxonase-1 (PON1) is an HDL-associated plasma enzyme that hydrolyzes diverse su
Externí odkaz:
https://doaj.org/article/881834b66423462f88e0ec16df8a387a
Autor:
David Meriwether, Dawoud Sulaiman, Alan Wagner, Victor Grijalva, Izumi Kaji, Kevin J. Williams, Liqing Yu, Spencer Fogelman, Carmen Volpe, Steven J. Bensinger, G.M. Anantharamaiah, Ishaiahu Shechter, Alan M. Fogelman, Srinivasa T. Reddy
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1175-1193 (2016)
The site and mechanism of action of the apoA-I mimetic peptide 4F are incompletely understood. Transintestinal cholesterol efflux (TICE) is a process involved in the clearance of excess cholesterol from the body. While TICE is responsible for at leas
Externí odkaz:
https://doaj.org/article/b26b9f1dc7ec4299aa9fac21656a74fb
Autor:
Faheem W. Guirgis, Vinitha Jacob, Dongyuan Wu, Morgan Henson, Kimberly Daly-Crews, Charlotte Hopson, Lauren Page Black, Elizabeth L. DeVos, Dawoud Sulaiman, Guillaume Labilloy, Todd M. Brusko, Jordan A. Shavit, Andrew Bertrand, Matthew Feldhammer, Brett Baskovich, Kiley Graim, Susmita Datta, Srinivasa T. Reddy
Objective: Sepsis patients experience poor outcomes including chronic critical illness (CCI) or early death (within 14 days). We investigated lipid metabolic gene expression differences by outcome to discover therapeutic targets. Design: Secondary an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba65d265cd49d05849dc654f52e2fe18
https://doi.org/10.21203/rs.3.rs-2500497/v1
https://doi.org/10.21203/rs.3.rs-2500497/v1
Autor:
Srinivasa T. Reddy, Asokan Devarajan, Jingyuan Li, Alan M. Fogelman, Mansoureh Eghbali, Dawoud Sulaiman, Gregory A. Fishbein, Min Li, Christine M. Cunningham
Publikováno v:
Journal of Molecular and Cellular Cardiology. 129:154-164
Objective To investigate the novel role of Paraoxonase 2 (PON2) in modulating acute myocardial ischemia-reperfusion injury (IRI). Approach IRI was induced both in vivo and ex vivo in male, C57BL6/J (WT) and PON2-deficient (PON-def) mice. In addition,
Publikováno v:
Circulation Research. 125
Introduction: We have recently reported that PON2 plays a protective role against myocardial ischemia-reperfusion injury (IRI) by reducing oxidative stress and mitochondrial dysfunction, in the form of improved calcium retention capacity and integrit
Autor:
Martin G. Martin, Carmen Volpe, Dawoud Sulaiman, Jiafang Wang, Anna Dorfman, R. Sergio Solorzano-Vargas, Nasrin Dorreh, Ellen I O’Connor, Victor Grijalva, Harvey R. Herschman, Mayakonda N. Palgunachari, Alan M. Fogelman, David Meriwether, Gattadahalli M. Anantharamaiah, Hannah Trost, Jeremy Papesh, Muriel H. Larauche, Srinivasa T. Reddy
Publikováno v:
The Journal of clinical investigation. 129(9)
Cyclooxygenase 2 (Cox2) total knockout and myeloid knockout (MKO) mice develop Crohn’s-like intestinal inflammation when fed cholate-containing high-fat diet (CCHF). We demonstrated that CCHF impaired intestinal barrier function and increased trans
Abstract 17401: Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia and Liver Steatosis
Autor:
Fen Yin, Will Driscoll, Dawoud Sulaiman, Laurent Vergnes, Jerry Ricks, Gajalakshmi Ramanathan, James Stewart, Margarete Mehrabian, Simon W Beaven, Karen Reue, Aldons J Lusis, Michael E Rosenfeld, Jesus A Araujo
Publikováno v:
Circulation, vol 138, iss Suppl_1
Introduction: Air pollution associates with increased cardiovascular morbidity and mortality, partly due to induction of dyslipidemia and metabolic syndrome. Our goal was to dissect mechanisms involved. Hypothesis: Diesel exhaust exposure induces hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476d21f51718cec83964dfbbc1ceab4c
https://escholarship.org/uc/item/2sz613fj
https://escholarship.org/uc/item/2sz613fj