Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dawn R. Church"'
Autor:
Farideh Mehraein-Ghomi, Dawn R. Church, Ashley M. Weichmann, G. Wilding, Cynthia L. Schreiber, Hirak S. Basu
Publikováno v:
Genes & Cancer
Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer, even under low androgen levels or in the absence of androgen in the castration-resistant pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af8fb41a98aa03d9fe5f573f7bb7481
https://doi.org/10.18632/genesandcancer.77
https://doi.org/10.18632/genesandcancer.77
Autor:
Farideh Mehraein-Ghomi, George Wilding, Dawn R. Church, Stacy J. Kegel, Hirak S. Basu, Joseph S. Schmidt, Quentin R. Reuter, Elizabeth L. Saphner
Publikováno v:
The Prostate. 74:792-803
BACKGROUND Multiple studies show that reactive oxygen species (ROS) play a major role in prostate cancer (PCa) development and progression. Previously, we reported an induction of Spermidine/Spermine N1-Acetyl Transferase (SSAT) by androgen-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2637ebb6132e990b7ee2d976953e554e
https://doi.org/10.1002/pros.22800
https://doi.org/10.1002/pros.22800
Autor:
Farideh Mehraein-Ghomi, George Wilding, Hirak S. Basu, Todd A. Thompson, Dawn R. Church, Elyse Lee
Publikováno v:
The Prostate. 68:924-934
BACKGROUND. Numerous and compelling evidence shows that high level of reactive oxygen species (ROS) plays a key role in prostate cancer occurrence, recurrence and progression. The molecular mechanism of ROS overproduction in the prostate gland, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4374aca695d567426bc8dbabffe7a71
https://doi.org/10.1002/pros.20737
https://doi.org/10.1002/pros.20737
Autor:
Dawn R. Church, Herbert Manoharan, Terry D. Oberley, Ajit K. Verma, Weixiong Zhong, Nancy E. Dreckschmidt, Moammir H. Aziz, George Wilding
Publikováno v:
Cancer Research. 67:8828-8838
Prostate cancer is the most common type of cancer in men and ranks second only to lung cancer in cancer-related deaths. The management of locally advanced prostate cancer is difficult because the cancer often becomes hormone insensitive and unrespons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3212a0c5a9f38c61d27a1ff56d55d27d
https://doi.org/10.1158/0008-5472.can-07-1604
https://doi.org/10.1158/0008-5472.can-07-1604
Autor:
Jianhua Ju, Sheng-Xiong Huang, Bong Sik Yun, Gudrun Ingenhorst, Hirak S. Basu, Ben Shen, Yong Huang, Gong-Li Tang, Dong Yang, Tao Liu, Dawn R. Church, Ming Ma, Jeremy R. Lohman, George Wilding
Leinamycin (LNM) is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140, featuring an unusual 1,3-dioxo-1,2-dithiolane moiety that is spiro-fused to a thiazole-containing 18-membered lactam ring. Upon reductive activation in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2ef29dfb5fc41b89f6915cfc69598b
https://europepmc.org/articles/PMC4500275/
https://europepmc.org/articles/PMC4500275/
Autor:
Farideh Mehraein, Hirak S. Basu, Ashley M. Weichmann, Jiaquan Yu, Laurie L. Parker, Wei Huang, Alexandria Craig, Dawn R. Church, David J. Beebe, George Wilding
Publikováno v:
Cancer Research. 76:4968-4968
Background: Castrate-resistant prostate cancer (CRPC) is the second leading cause of cancer deaths among US men. Currently, a large number of small and low grade prostate cancers (PCa) are being diagnosed. Only a few of them will metastasize and beco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144c6bd24f26de4b2bb9d9438b763460
https://doi.org/10.1158/1538-7445.am2016-4968
https://doi.org/10.1158/1538-7445.am2016-4968
Autor:
Dawn R. Church, Bing Yang, Joshua A. Desotelle, Wei Huang, David F. Jarrard, Timo Laurila, Jonathan A. Ewald
Publikováno v:
The Prostate. 73(4)
BACKGROUND The treatment of non-localized prostate cancer involves androgen deprivation (AD) therapy which results in tumor regression. Apoptosis has been implicated in the tumor response to AD, but constitutes a small fraction of the total tumor at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579fe5f9452e4a9dfdab8e390595a901
https://pubmed.ncbi.nlm.nih.gov/22911222
https://pubmed.ncbi.nlm.nih.gov/22911222
Publikováno v:
Journal of Urology. 185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::751e8b93c438fa3445c87698631f2924
https://doi.org/10.1016/j.juro.2011.02.1358
https://doi.org/10.1016/j.juro.2011.02.1358
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC The relatively high oxidative stress in the prostate is postulated to be one of the major factors for prostate carcinogenesis and prostate cancer (CaP) progression. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf4d32239b0b9e66a996f3c4bb45a5c
https://europepmc.org/articles/PMC2909607/
https://europepmc.org/articles/PMC2909607/
Autor:
Corey A. Amlong, Mary J. Lindstrom, Hirak S. Basu, Dawn R. Church, Cynthia C. Clower, Patrick M. Woster, George Wilding, Todd A. Thompson, Farideh Mehraein-Ghomi, Christopher T. Martin
Publikováno v:
Cancer research. 69(19)
High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e002f934ffb8a439eedd5f41f0f6413
https://pubmed.ncbi.nlm.nih.gov/19773450
https://pubmed.ncbi.nlm.nih.gov/19773450