Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dawn P. G. Brown"'
Publikováno v:
Journal of Chromatography B. 878:700-704
Protein quantification in a complex protein mixture presents a daunting task in biochemical analysis. Antibody-based immunoassays are traditional methods for protein quantification. However, there are issues associated with accuracy and specificity i
Publikováno v:
Cancer Chemotherapy and Pharmacology. 63:723-730
Clinical drug resistance to platinum-based chemotherapy is considered a major impediment in the treatment of human ovarian cancer. Multiple pathways associated with drug resistance have been suggested by many previous studies. Over expression of seve
Publikováno v:
Briefings in Functional Genomics and Proteomics. 7:329-339
Major technological advances have made proteomics an extremely active field for biomarker discovery and validation in recent years. These improvements have lead to an increased emphasis on larger scale, faster and more efficient methods for protein b
Publikováno v:
Journal of Molecular Biomarkers & Diagnosis.
Over 15,000 women die from ovarian cancer and there are approximately 23,000 new cases diagnosed each year. Platinum-based chemotherapy is still the primary treatment for ovarian cancer. Most patients with the disease are initially responsive to chem
Autor:
Robert W. Siegel, Dotzlaf Joe Edward, John W. Carpenter, Dawn P. G. Brown, Chin Liu, P.G. Mitchell, Michael Robert Wiley, Kannan Thirunavukkarasu, D. A. Laska, Jothirajah Marimuthu, Quincy L. Carter, I.J. Brittain, Craig A. Swearingen, James Lee Toth, Timothy B. Durham, Kevin L. Duffin
Publikováno v:
Osteoarthritis and cartilage. 18(9)
Summary Objective Proteolytic degradation of aggrecan in articular cartilage is a hallmark feature of osteoarthritis (OA). The present study was aimed at developing a sensitive enzyme linked immunosorbent assay (ELISA) for the detection of aggrecanas
Publikováno v:
Computational Systems Bioinformatics.
In ovarian cancer treatment, the chemotherapy drug cisplatin often induce drug resistance after prolonged use, causing cancer relapse and the eventual deaths of patients. Cisplatin-induced drug resistance is known to involve a complex set of cellular
Autor:
Dawn P. G. Brown, Jian Tan, George W. Sledge, Yesim Gökmen-Polar, Heather N. Ringham, Li Jiang, Guihong Qi, Frank A. Witzmann, Mu Wang, Dariusz J. Janecki
Publikováno v:
Proteomics. Clinical applications. 1(1)
Drug resistance is a major impediment to the successful treatment of human cancers, including ovarian cancer. Vinblastine (VLB), an antimicrotubule agent, is one of the chemotherapeutic drugs that exhibit resistance in ovarian cancer patients. To det