Výsledky vyhledávání - "Dawn M. Wong"

Akademický článek

Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae

Autor: James M. Mutunga, Qiao-Hong Chen, Dawn M. Wong, Polo C-H. Lam, Jianyong Li, Maxim M. Totrov, Aaron D. Gross, Paul R. Carlier, Jeffrey R. Bloomquist

Publikováno v: CHIMIA, Vol 70, Iss 10 (2016)

Widespread pyrethroid resistance has caused an urgent need to develop new insecticides for control of the malaria mosquito, Anopheles gambiae. Insecticide discovery efforts were directed towards the construction of bivalent inhibitors that occupy bot

Externí odkaz: https://doaj.org/article/304d974ecc6945a8af3bfffb6f19d76b

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Akademický článek

Select small core structure carbamates exhibit high contact toxicity to 'carbamate-resistant' strain malaria mosquitoes, Anopheles gambiae (Akron).

Autor: Dawn M Wong, Jianyong Li, Qiao-Hong Chen, Qian Han, James M Mutunga, Ania Wysinski, Troy D Anderson, Haizhen Ding, Tiffany L Carpenetti, Astha Verma, Rafique Islam, Sally L Paulson, Polo C-H Lam, Maxim Totrov, Jeffrey R Bloomquist, Paul R Carlier

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46712 (2012)

Acetylcholinesterase (AChE) is a proven target for control of the malaria mosquito (Anopheles gambiae). Unfortunately, a single amino acid mutation (G119S) in An. gambiae AChE-1 (AgAChE) confers resistance to the AChE inhibitors currently approved by

Externí odkaz: https://doaj.org/article/5787d6ace9ba45baa6e7309d3a591b29

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Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

Autor: Paul R. Carlier, Qiao-Hong Chen, Astha Verma, James M. Mutunga, Jianyong Li, Jeffrey R. Bloomquist, Fan Tong, Alex M. Shimozono, Dawn M. Wong, Max Totrov, Jasmin Müller, Rafique Islam

Publikováno v: Pesticide Biochemistry and Physiology. 151:32-39

The widespread emergence of pyrethroid-resistant Anopheles gambiae has intensified the need to find new contact mosquitocides for indoor residual spraying and insecticide treated nets. With the goal of developing new species-selective and resistance-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db90b0eac40d840d88ce4b915bbb7bce
https://doi.org/10.1016/j.pestbp.2018.02.003

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Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae

Autor: Paul R. Carlier, Polo C.-H. Lam, Maxim Totrov, Dawn M. Wong, Howard Robinson, Qian Han, Haizhen Ding, Jianyong Li

Publikováno v: Insect Science. 25:721-724

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecab7db849d4f4d0072d0d4d4b838f3f
https://doi.org/10.1111/1744-7917.12450

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Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates

Autor: James M. Mutunga, Joshua A. Hartsel, Max Totrov, Ming Ma, Jeffrey R. Bloomquist, Qiao-Hong Chen, Sha Ding, Dawn M. Wong, Paul R. Carlier

Publikováno v: International Journal of Environmental Research and Public Health
Volume 16
Issue 9
International Journal of Environmental Research and Public Health, Vol 16, Iss 9, p 1500 (2019)

New insecticides are needed for control of disease-vectoring mosquitoes and this research evaluates the activity of new carbamate acetylcholinesterase (AChE) inhibitors. Biochemical and toxicological characterization of carbamates based on the parent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db6229c88b81bb3a07c0f4acbf67c5c

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Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

Autor: Florian Körber, Paul R. Carlier, Elisabet Viayna, Jianyong Li, Maxim Totrov, Dawn M. Wong, Aaron D. Gross, Rafique Islam, Jeffrey R. Bloomquist, Fan Tong, James M. Mutunga, Eugene Camerino

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:4405-4411

Malaria is a devastating disease in sub-Saharan Africa, and current vector control measures are threatened by emerging resistance mechanisms. With the goal of developing new, selective, resistance-breaking insecticides we explored α-fluorinated meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee27f0a3a82d4c2054c75a8a19d1cbe
https://doi.org/10.1016/j.bmcl.2015.09.019

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Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae

Autor: James M. Mutunga, Daniel R. Swale, Paul R. Carlier, Troy D. Anderson, Derek T. Craft, Jeffrey R. Bloomquist, Fan Tong, Dawn M. Wong, Aaron D. Gross

Publikováno v: Pesticide Biochemistry and Physiology. 121:116-121

Insecticide resistance in the malaria vector, Anopheles gambiae, is a serious problem, epitomized by the multi-resistant Akron strain, originally isolated in the country of Benin. Here we report resistance in this strain to pyrethroids and DDT (13-fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619e92b9143b4ea122396b1072d6d293
https://doi.org/10.1016/j.pestbp.2015.03.001

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NEUROTOXICOLOGY OFbis(n)-TACRINES ONBlattella germanicaANDDrosophila melanogasterACETYLCHOLINESTERASE

Autor: James M. Mutunga, Dhana Raj Boina, Jeffrey R. Bloomquist, Troy D. Anderson, Paul R. Carlier, Polo C.-H. Lam, Maxim Totrov, Dawn M. Wong

Publikováno v: Archives of Insect Biochemistry and Physiology. 83:180-194

A series of bis(n)-tacrines were used as pharmacological probes of the acetylcholinesterase (AChE) catalytic and peripheral sites of Blattella germanica and Drosophila melanogaster, which express AChE-1 and AChE-2 isoforms, respectively. In general,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::474983caebeefa64e3714ff833b9508e
https://doi.org/10.1002/arch.21104

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