Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dawn M. Riddle"'
Autor:
Courtney A. Marshall, Jennifer D. McBride, Lakshmi Changolkar, Dawn M. Riddle, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. AD patients display increases in hyperphosphorylated tau and synaptic activity. Previous studies have individual
Externí odkaz:
https://doaj.org/article/6701d14350d140dbb6bdce7263329ac0
Autor:
Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle, Susan N. Leight, Lakshmi Changolkar, Hong Xu, Emily S. Meymand, Mia O’Reilly, Bin Zhang, Kurt R. Brunden, John Q. Trojanowski, Virginia M. Y. Lee
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background The spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve
Externí odkaz:
https://doaj.org/article/09dd55fddba54de1b0145828289b3cae
Autor:
Michael X. Henderson, Dustin J. Covell, Charlotte Hiu-Yan Chung, Rose M. Pitkin, Raizel M. Sandler, Samantha C. Decker, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Michael J. James, John Q. Trojanowski, Kurt R. Brunden, Virginia M.Y. Lee, Kelvin C. Luk
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104712- (2020)
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there is
Externí odkaz:
https://doaj.org/article/2065928935b24bed8f41f6623a293ece
Autor:
Jennifer D. McBride, Bin Zhang, Kurt R. Brunden, Lakshmi Changolkar, Virginia M.-Y. Lee, Jeffrey J. Nirschl, Kevt’her Hoxha, John Q. Trojanowski, Hong Xu, Garrett S. Gibbons, Gerard D. Schellenberg, Mia O’Reilly, Soo-Jung Kim, Dawn M. Riddle, Anna Stieber
Publikováno v:
Acta Neuropathologica
The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and biochemically defined as distinct tau strains. Recent studies show that these tau strains exhibit str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bfc6721968f29707c0c097e52f976d
http://europepmc.org/articles/PMC7847465
http://europepmc.org/articles/PMC7847465
Autor:
Hong Xu, Bin Zhang, Garrett S. Gibbons, Dawn M. Riddle, Mia O’Reilly, Kurt R. Brunden, Emily S. Meymand, Qihui Wu, Virginia M.-Y. Lee, John Q. Trojanowski, Lakshmi Changolkar, Susan Leight, Soo-Jung Kim
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
BackgroundThe spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve cellular t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38187d84c538a237376b12ae386e15c
http://europepmc.org/articles/PMC7643305
http://europepmc.org/articles/PMC7643305
Autor:
Dustin J. Covell, Rose M. Pitkin, Samantha C. Decker, Ronald J. Gathagan, Virginia M.-Y. Lee, Kelvin C. Luk, John Q. Trojanowski, Charlotte Hiu-Yan Chung, Kurt R. Brunden, Michael X. Henderson, Dawn M. Riddle, Raizel M. Sandler, Michael J. James, Bin Zhang
Publikováno v:
Neurobiology of Disease, Vol 136, Iss, Pp 104712-(2020)
Neurobiol Dis
Neurobiol Dis
Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed07650d4d578bc32dff82fe94d83b94
http://www.sciencedirect.com/science/article/pii/S0969996119303870
http://www.sciencedirect.com/science/article/pii/S0969996119303870
Autor:
Samantha Sedor, Danielle S. Bassett, Hannah J. Brown, Ian McGeary, Eli J. Cornblath, John Q. Trojanowski, Chao Peng, Dawn M. Riddle, Michael X. Henderson, Howard L. Li, Virginia M.-Y. Lee, Modupe F. Olufemi, Bin Zhang
Publikováno v:
Neuron
Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been linked to accumulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5468c10f4a4503d6c57527a41436aa6
https://europepmc.org/articles/PMC7060125/
https://europepmc.org/articles/PMC7060125/
Autor:
Sarah A Weitzman, Dawn M. Riddle, Zhiyong Li, Lakshmi Changolkar, Erik D. Roberson, Anna Stieber, Bin Zhang, Alexandra Kats, Sneha Narasimhan, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Journal of Experimental Medicine. 217
Tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. In Alzheimer’s disease (AD), tau aggregates in neurons, while in corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), tau also aggregate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9248d0ef529ce7f98a277e4b4a7dbf6
https://doi.org/10.1084/jem.20190783
https://doi.org/10.1084/jem.20190783
Autor:
Ronald J. Gathagan, Bum-Jin Kim, Susan Leight, Rachel A. Banks, Hannah J. Brown, Dawn M. Riddle, Hong Xu, Garrett S. Gibbons, John Q. Trojanowski, Virginia M.-Y. Lee, Chi Li, Bin Zhang, Lakshmi Changolkar
Publikováno v:
The Journal of Neuroscience. 37:11485-11494
Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae337622dc8c2eaadb75acef01018b0
https://doi.org/10.1523/jneurosci.2393-17.2017
https://doi.org/10.1523/jneurosci.2393-17.2017
Autor:
Dustin J. Covell, John Q. Trojanowski, Dan Weintraub, Murray Grossman, Rizwan S. Akhtar, Ahmed Yousef, Rose M. Pitkin, Virginia M.-Y. Lee, H. M. Bucklin, John L. Robinson, Dawn M. Riddle
Publikováno v:
Neuropathology and Applied Neurobiology. 43:604-620
Aims The aim of this study was to test the hypothesis that different conformations of misfolded α-synuclein (α-syn) are present in Parkinson's disease (PD) brain. Methods Using two previously characterized conformations of α-syn fibrils, we genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8587b6ed5bee3f64d98604b6bc5187a9
https://doi.org/10.1111/nan.12402
https://doi.org/10.1111/nan.12402