Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dawn M. Jelley-Gibbs"'
Autor:
Rui Yang, Dario Lirussi, Tina M Thornton, Dawn M Jelley-Gibbs, Sean A Diehl, Laure K Case, Muniswamy Madesh, Douglas J Taatjes, Cory Teuscher, Laura Haynes, Mercedes Rincón
Publikováno v:
eLife, Vol 4 (2015)
IL-6 plays an important role in determining the fate of effector CD4 cells and the cytokines that these cells produce. Here we identify a novel molecular mechanism by which IL-6 regulates CD4 cell effector function. We show that IL-6-dependent signal
Externí odkaz:
https://doaj.org/article/c65fbc73b4a04bbea1471bbd828c20b1
Autor:
Rui Yang, Tina M. Thornton, Douglas J. Taatjes, Mercedes Rincon, Muniswamy Madesh, Laure K. Case, Dario Lirussi, Laura Haynes, Cory Teuscher, Dawn M. Jelley-Gibbs, Sean A. Diehl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcca3338711f9c96c2f2d3405e9b26c3
https://doi.org/10.7554/elife.06376.018
https://doi.org/10.7554/elife.06376.018
Autor:
Douglas J. Taatjes, Laure K. Case, Laura Haynes, Dawn M. Jelley-Gibbs, Sean A. Diehl, Cory Teuscher, Tina M. Thornton, Dario Lirussi, Rui Yang, Muniswamy Madesh, Mercedes Rincon
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
IL-6 plays an important role in determining the fate of effector CD4 cells and the cytokines that these cells produce. Here we identify a novel molecular mechanism by which IL-6 regulates CD4 cell effector function. We show that IL-6-dependent signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33824adee3466bdbda68240678d952a
http://europepmc.org/articles/PMC4447996
http://europepmc.org/articles/PMC4447996
Autor:
Nico Ghilardi, Andrea M. Cooper, Santiago Partida-Sanchez, Shabaana A. Khader, Guy K. Bell, Susan L. Swain, Frederic Desauvage, Frances E. Lund, Dawn M. Jelley-Gibbs, John E. Pearl
Publikováno v:
The Journal of Experimental Medicine
Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f02519e9d74956eac15136d826a44
https://doi.org/10.1084/jem.20052545
https://doi.org/10.1084/jem.20052545
Autor:
Deborah M. Brown, Laura Haynes, Sheri M. Eaton, Dawn M. Jelley-Gibbs, Susan L. Swain, John P. Dibble
Publikováno v:
The Journal of Experimental Medicine
The kinetics of presentation of influenza virus–derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee71db5978265faf3221e1d45d429c5
https://doi.org/10.1084/jem.20050227
https://doi.org/10.1084/jem.20050227
Autor:
Dawn M. Jelley-Gibbs, Roslyn A. Kemp, John P. Dibble, Laura Haynes, Svetlana Filipson, Susan L. Swain
Publikováno v:
The Journal of Experimental Medicine
Chronic infections often result in CD8 T-cell deletion or functional nonresponsiveness. However, to date no definitive studies have attempted to determine the impact of repeated T cell receptor stimulation on CD4 effector T cell generation. We have d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327c322279b24d930f526604222ebacb
https://doi.org/10.1084/jem.20041852
https://doi.org/10.1084/jem.20041852
Publikováno v:
The Journal of Immunology. 165:5017-5026
Efficient peptide presentation by professional APC to naive and effector CD4 T cells in vitro is limited to the first 1–2 days of culture, but is nonetheless optimum for effector expansion and cytokine production. In fact, prolonging Ag presentatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92a633c119bbdeb2bf43a4ffb5e2e9e
https://doi.org/10.4049/jimmunol.165.9.5017
https://doi.org/10.4049/jimmunol.165.9.5017
Publikováno v:
Expert review of clinical immunology. 2(4)
Influenza virus epidemics are responsible for approximately 1 million human deaths annually, and a pandemic caused by H5N1 avian influenza viruses could result in over 50 million deaths. Current vaccine strategies cannot prevent the first wave of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf7923735ac8859f10d0b9bbf80e1d7
https://pubmed.ncbi.nlm.nih.gov/20477616
https://pubmed.ncbi.nlm.nih.gov/20477616
Autor:
David L. Woodland, Susan T. Wittmer, Dawn M. Jelley-Gibbs, Shiki Takamura, Alan D. Roberts, Jacob E. Kohlmeier
Publikováno v:
The Journal of Experimental Medicine
After respiratory virus infections, memory CD8+ T cells are maintained in the lung airways by a process of continual recruitment. Previous studies have suggested that this process is controlled, at least in the initial weeks after virus clearance, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9e44d58ae6f08eb8c8c93fbd6f0b4b
https://pubmed.ncbi.nlm.nih.gov/20457758
https://pubmed.ncbi.nlm.nih.gov/20457758
Publikováno v:
Immunology and cell biology. 86(4)
In the face of emerging infectious diseases caused by rapidly evolving and highly virulent pathogens, such as influenza, we are challenged to develop innovative vaccine strategies that can induce lasting protection. Since CD4 T cells are needed to ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7202c9dcfcfcbf3b37a02bac7b314a
https://pubmed.ncbi.nlm.nih.gov/18362946
https://pubmed.ncbi.nlm.nih.gov/18362946