Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dawn M Little"'
Autor:
Yoshiaki Takahashi, Siddappa N Byrareddy, Christina Albrecht, Markus Brameier, Lutz Walter, Ann E Mayne, Paul Dunbar, Robert Russo, Dawn M Little, Tara Villinger, Ladawan Khowawisetsut, Kovit Pattanapanyasat, Francois Villinger, Aftab A Ansari
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003929 (2014)
The studies reported herein are the first to document the effect of the in vivo administration of a JAK3 inhibitor for defining the potential role of NK cells during acute SIV infection of a group of 15 rhesus macaques (RM). An additional group of 16
Externí odkaz:
https://doaj.org/article/f22d7c03809e419091570a416fa08497
Autor:
Ladawan Khowawisetsut, Kovit Pattanapanyasat, Nattawat Onlamoon, Ann E Mayne, Dawn M Little, Francois Villinger, Aftab A Ansari
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61264 (2013)
Comprehensive studies of the frequencies and absolute numbers of the various cell lineages that synthesize IL-17 in the blood and corresponding gastrointestinal (GI) tissues, their correlation with CD4(+) Tregs, CD8(+) Tregs, total and IFN-α synthes
Externí odkaz:
https://doaj.org/article/bd077457448c46a99afb7c6d6cbda11b
Autor:
Anthony S. Fauci, Katija Jelicic, Kenneth A. Rogers, James Arthos, Claudia Cicala, Francois Villinger, Jung Joo Hong, Aftab A. Ansari, Siddappa N. Byrareddy, Sanjeev Gumber, Philip J. Santangelo, Kristina Ortiz, Kevin E. Lindsay, Chiara Zurla, Dawn M. Little
Publikováno v:
Mucosal Immunology. 11:932-946
Integrin α4β7 mediates the trafficking of leukocytes, including CD4+ T cells, to lymphoid tissues in the gut. Virus mediated damage to the gut is implicated in HIV and SIV mediated chronic immune activation and leads to irreversible damage to the i
Autor:
Kelly B. Arnold, Maureen A. Kane, Michelle D. Reid, Jianshi Yu, Neil Sidell, Katija Jelicic, Dawn M. Little, Volkan Adsay, Lyle R. McKinnon, Caroline E. Woody, Aftab A. Ansari, Philip J. Santangelo, Siddappa N. Byrareddy, Donald Van Ryk, James Arthos, Anthony S. Fauci, Praveen K. Amancha, Francois Villinger, Christian Roos, Claudia Cicala, Angela Noll, Chiara Zurla, Raffaello Cimbro, Sanjeev Gumber, Jace W. Jones, Kristina Ortiz, Tristram G. Parslow, Lutz Walter, Ann E. Mayne
Antibodies sustain viral control For many infected individuals, antiretroviral therapy (ART) means that an HIV-1 diagnosis is no longer a death sentence. But the virus persists in treated individuals, and complying with the intense drug regimen to ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3ef38d3d6469f995648d293db7d272
https://europepmc.org/articles/PMC5405455/
https://europepmc.org/articles/PMC5405455/
Autor:
Elena V. Ryzhova, Yanjie Yi, James G. Else, Lawrence R. Sternberg, Ronald G. Collman, Alexandra M. Ortiz, Bing Li, Paul M. Carnathan, Brian Tabb, Sarah J. Ratcliffe, Jessica C. Engram, Xing Pei Hao, Francisco Gonzalez-Scarano, Elizabeth M. Cramer, Nichole R. Klatt, Benton Lawson, Jason M. Brenchley, Dawn M. Little, Mirko Paiardini, Aftab A Ansari, Jacob D. Estes, Cynthia A. Derdeyn, Guido Silvestri
Publikováno v:
Journal of Clinical Investigation. 121:4433-4445
CD4+ T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion during chronic HIV infection is a hallmark of disease progression. However, the relative contribution of CD4+ T cells as mediators of antiviral immune respons
Autor:
Susan T. Stephenson, Keith A. Reimann, Francois Villinger, Robert H. Lyles, Ann E. Mayne, Xinyue Wang, Yoshiaki Takahashi, Aftab A. Ansari, Andrew A. Price, Rijian Wang, Mohammad Y. Zaidi, Jichu Li, Dawn M. Little
Publikováno v:
The Journal of Immunology. 186:1044-1059
Intravenous administration of a novel recombinant rhesus mAb against the α4β7 gut-homing integrin (mAb) into rhesus macaques just prior to and during acute SIV infection resulted in significant decrease in plasma and gastrointestinal (GI) tissue vi
Autor:
Lara Pereira, Mark Bouzyk, Francois Villinger, Weining Tang, Aftab A. Ansari, Susan T. Stephenson, Jaruda Kobkitjaroen, Dawn M. Little, Pavel Bostik
Publikováno v:
The Journal of Immunology. 182:3638-3649
NK cells have been established as an important effector of innate immunity in a variety of viral infections. In HIV-1 infection in humans, alterations of NK cell function, frequency, and expression of various NK receptors have been reported to be ass
Autor:
Byeongwoon Song, James Arthos, Anthony S. Fauci, Francois Villinger, Maureen A. Kane, Keely Pierzchalski, Gui X. Yang, Claudia Cicala, Ann E. Mayne, Neil Sidell, Paul Dunbar, Chunxia Zhao, Marcelo A. Soares, Aftab A. Ansari, Siddappa N. Byrareddy, Dawn M. Little
Among nonhuman primates, SIV-infected Asian pigtailed macaques (PM) are relatively more susceptible to infection and disease progression than SIV-infected rhesus macaques (RM). In addition, SIV-infected African natural hosts such as the sooty mangabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e091d17b43ecc4b6bff48308b421a858
https://europepmc.org/articles/PMC4722869/
https://europepmc.org/articles/PMC4722869/
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140689 (2015)
PLoS ONE
PLoS ONE
Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HI
Publikováno v:
The Journal of Immunology. 172:4391-4401
Evidence that human progenitor mast cells are susceptible to infection with CCR5-tropic strains of HIV-1 and that circulating HIV-1-infected FcεRIα+ cells with a similar progenitor phenotype have been isolated from AIDS patients has led to speculat