Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Dawn L. Thiselton"'
Autor:
Zhongming Zhao, Bradley T Webb, Peilin Jia, T Bernard Bigdeli, Brion S Maher, Edwin van den Oord, Sarah E Bergen, Richard L Amdur, Francis A O'Neill, Dermot Walsh, Dawn L Thiselton, Xiangning Chen, Carlos N Pato, International Schizophrenia Consortium, Brien P Riley, Kenneth S Kendler, Ayman H Fanous
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67776 (2013)
Integrating evidence from multiple domains is useful in prioritizing disease candidate genes for subsequent testing. We ranked all known human genes (n=3819) under linkage peaks in the Irish Study of High-Density Schizophrenia Families using three di
Externí odkaz:
https://doaj.org/article/e23b3ee76ed54800bdaa5b1763265c63
Autor:
T Bernard Bigdeli, Brion S Maher, Zhongming Zhao, Edwin J C G van den Oord, Dawn L Thiselton, Jingchun Sun, Bradley T Webb, Richard L Amdur, Brandon Wormley, Francis A O'Neill, Dermot Walsh, Brien P Riley, Kenneth S Kendler, Ayman H Fanous
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e21440 (2011)
Prior genomewide scans of schizophrenia support evidence of linkage to regions of chromosome 20. However, association analyses have yet to provide support for any etiologically relevant variants.We analyzed 2988 LD-tagging single nucleotide polymorph
Externí odkaz:
https://doaj.org/article/2d2d05f6ed854f6da9f843265cf68463
Autor:
Joseph P. McConnell, Leila Ghaedi, James Bruton, Dawn L. Thiselton, Stephen A. Varvel, Thomas D. Dayspring
Publikováno v:
Journal of Clinical Lipidology. 9:807-816
BackgroundCirculating noncholesterol sterols/stanols (NCS) are used in clinical lipidology as surrogate measures of cholesterol synthesis and absorption, where they can be valuable tools in assessing cholesterol metabolism and personalizing therapies
Autor:
Tara Dall, Joseph P. McConnell, Stephen A. Varvel, G. Russell Warnick, Thomas D. Dayspring, Justin White, Elliott Wolin, William S. Harris, Dawn L. Thiselton, James V. Pottala, Daniel M. Hoefner, Maciek Sasinowski
Publikováno v:
Journal of Clinical Lipidology. 9:817-823
Background Clinical laboratory patient databases are an untapped source of valuable diagnostic and prognostic information. However, the lack of associated clinical and/or demographic information and questionable generalizability to nonpatient populat
Autor:
Jonathan K. Davis, Gwen Corley Creighton, James S. Clifford, Dawn L. Thiselton, De’Nisha Wilson, Alexis C. Edwards, Courtney Blondino, Peter B. Barr, Joshua Montgomery, Cynthia Newbille, Elizabeth Prom-Wormley, Joseph E. Real, Kevin M. Ball, Jessica L. Bourdon
Publikováno v:
Soc Sci Med
Background Family history (FH) is an underutilized genetically informative tool that can influence disease prevention and treatment. It is unclear how FH fits into the development of community-based health education. This study examines the role that
Autor:
Arden Moscati, Ayman H. Fanous, Kenneth S. Kendler, Anna R. Docherty, Brion S. Maher, Francis A. O'Neill, Dawn L. Thiselton, Dermot Walsh, Brandon Wormley, Silviu Alin Bacanu, Alexis C. Edwards, Brien P. Riley, Tim B. Bigdeli, Donghyung Lee, Teresa R de Candia
Publikováno v:
Schizophrenia Bulletin. 42:279-287
Background Evidence suggests that genetic factors may influence both schizophrenia (Scz) and its clinical presentation. In recent years, genome-wide association studies (GWAS) have demonstrated considerable success in identifying risk loci. Detection
Autor:
Alexis C, Edwards, Tim B, Bigdeli, Anna R, Docherty, Silviu, Bacanu, Donghyung, Lee, Teresa R, de Candia, Arden, Moscati, Dawn L, Thiselton, Brion S, Maher, Brandon K, Wormley, Dermot, Walsh, Francis A, O'Neill, Kenneth S, Kendler, Brien P, Riley, Dragan M, Svrakic
Publikováno v:
Schizophrenia bulletin. 42(2)
Background: Evidence suggests that genetic factors may influence both schizophrenia (Scz) and its clinical presentation. In recent years, genome-wide association studies (GWAS) have demonstrated considerable success in identifying risk loci. Detectio
Autor:
Steven Thompson, John Barron, Shahrzad Grami, Ralph Turner, Szilard Voros, Dawn L. Thiselton, Stephen A. Varvel
Publikováno v:
Population Health Management. 17:121-126
In an effort to reduce cost and improve quality, health care payers have enacted a number of incentives to motivate providers to focus their efforts on achieving better clinical outcomes and reducing the prevalence and progression of disease. In resp
Autor:
Brien P. Riley, John I. Nurnberger, R.L. McNamee, Kenneth S. Kendler, Galina P. Kirillova, Tim B. Bigdeli, Howard Chilcoat, Brion S. Maher, Howard J. Edenberg, Vladimir I. Vladimirov, Bernie Devlin, Moonsu Kang, Ralph E. Tarter, Fazil Aliev, John M. Hettema, Christian Heidbreder, John Kramer, Robert E. Ferrell, Xiangning Chen, P. Muglia, Dawn L. Thiselton, Danielle M. Dick, Shawn J. Latendresse, Michael M. Vanyukov, E. Lenn Murrelle, Jay A. Tischfield, Arpana Agrawal
Publikováno v:
Biological Psychiatry. 70:519-527
Background The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms. Methods In 757 subjects, we performed association analysis between 1536 single nucleotide polymorphi
Autor:
Sarah E. Bergen, Kenneth S. Kendler, Francis A. O'Neill, Ayman H. Fanous, E J C G van den Oord, Brion S. Maher, Brien P. Riley, Zhongming Zhao, Dawn L. Thiselton, Tim B. Bigdeli, Declan Walsh, Richard Amdur, Brandon Wormley
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :663-674
SNAP25 occurs on chromosome 20p12.2, which has been linked to schizophrenia in some samples, and recently linked to latent classes of psychotic illness in our sample. SNAP25 is crucial to synaptic functioning, may be involved in axonal growth and den