Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dawn Kelly-Sullivan"'
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b646053b683b9aba0f84b9efef17df
https://doi.org/10.1016/j.chembiol.2021.08.012
https://doi.org/10.1016/j.chembiol.2021.08.012
Publikováno v:
Cell Transplantation, Vol 4 (1995)
Transplantation of unpurified islets into the liver, unlike that of purified islets, causes portal hypertension and coagulopathy. The aim of this project was to determine the most suitable alternative site for transplantation of unpurified pancreatic
Externí odkaz:
https://doaj.org/article/f79d3f4adeaf4a06a3bab2176abb44bd
Autor:
Jimmy Kong, Theunis C. Goosen, Kimberly O. Cameron, Samit Kumar Bhattacharya, Suvi T. M. Orr, Dilinie P. Fernando, Peter Cornelius, Eunsun Lee, Meihua Tu, Stefanus J. Steyn, David Austen Perry, Laura Michael, Jana Polivkova, Ann M. Janssen, Margaret Jackson, Jeffrey T. Kohrt, Ruduan Wang, Sylvie Perez, Hirokazu Ueno, Kimberly Lapham, Dawn Kelly-Sullivan, Victoria Bagdasarian, Roger Swartz, Ingrid A. Stock, Yingxin Zhang, Ryan Jones, Erasga Noe Ouano, Kim F. McClure, Wenhua Jiao, Daniel W. Kung, Guoqiang Wang, Hua Gao, Sam Varma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5410-5414
The optimization for selectivity and central receptor occupancy for a series of spirocyclic azetidine-piperidine inverse agonists of the ghrelin receptor is described. Decreased mAChR muscarinic M2 binding was achieved by use of a chiral indane in pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e6d8033acfd64e2624f92f66f339ad
https://doi.org/10.1016/j.bmcl.2013.07.044
https://doi.org/10.1016/j.bmcl.2013.07.044
Autor:
Rebecca E. O’Connor, Steven R. Schneider, Denise Gautreau, Philip A. Carpino, Karen M. Ward, Jeffrey S. Lizano, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Robert L. Dow, Dawn Kelly-Sullivan
Publikováno v:
ACS Medicinal Chemistry Letters. 3:397-401
Antagonism of cannabinoid-1 (CB1) receptor signaling has been demonstrated to inhibit feeding behaviors in humans, but CB1-mediated central nervous system (CNS) side effects have halted the marketing and further development of the lead drugs against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdcaa646cbb776cb05d86c09e6ede88
https://doi.org/10.1021/ml3000325
https://doi.org/10.1021/ml3000325
Autor:
Karen Siegel, Helen Kim Cho, David Looper, Shawn C Black, Xiao-Hong Yu, Scott Rp McDonnell, Dawn Kelly-Sullivan, Sergei Timofeevski, Junming Yie, Celia P. Briscoe, Kathleen M. Ogilvie, Ping Chen, Manli Shi, James S. Fraser
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E1142-E1151
c-Jun NH2-terminal kinase (JNK) plays an important role in insulin resistance; however, identification of pharmacologically potent and selective small molecule JNK inhibitors has been limited. Compound A has a cell IC50 of 102 nM and is at least 100-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cb6cb9c6eb48edf3850c4ed514bdf5
https://doi.org/10.1152/ajpendo.90298.2008
https://doi.org/10.1152/ajpendo.90298.2008
Publikováno v:
European Journal of Pharmacology. 462:125-132
We determined the effect of a cannabinoid CB1 receptor antagonist (AM-251; N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) on food intake, body weight and adipose tissue mass in Western diet-induced obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9926318404f82fba3366652d6ff048
https://doi.org/10.1016/s0014-2999(03)01343-8
https://doi.org/10.1016/s0014-2999(03)01343-8
Autor:
Denise Gautreau, Dawn Kelly-Sullivan, Jeffrey S. Lizano, Diane M. Hargrove, David A. Griffith, John R. Hadcock, Phillip Iredale, Rebecca E. O’Connor, Dennis O. Scott, Robert L. Dow, Phillip A. Carpino, Karen M. Ward, Shawn C Black
Publikováno v:
Biochemical and biophysical research communications. 394(2)
Cannabinoid CB(1) receptor antagonists exhibit pharmacologic properties favorable for the treatment of metabolic disease. CP-945,598 (1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino piperidine-4-carboxylic acid amide hydrochlorid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c09cd2fb0e2030362820517325eb9a8
https://pubmed.ncbi.nlm.nih.gov/20211605
https://pubmed.ncbi.nlm.nih.gov/20211605
Autor:
Karen M. Ward, Mary Butler, Denise Gautreau, Subas M. Sakya, Joseph DiBrino, Jeff S. Lizano, Colin R. Rose, David A. Griffith, Shawn C Black, John R. Hadcock, Darrin Dutcher, Rebecca E. O’Connor, Dawn Kelly-Sullivan, Philip A. Iredale, Dennis O. Scott, Demetria B. DeBartolo, Philip A. Carpino, Michael Fichtner, Robert L. Dow, Michelle A. Sands, Robert F. Day
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(3)
A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB(1)-R antagonists and inverse agonists. Optimization of the structure-activity relationships around the 2,6-dihydro-pyrazolo[4,3-d]py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102f6cb9677fa5c134d08a6d06f1c420
https://pubmed.ncbi.nlm.nih.gov/16263283
https://pubmed.ncbi.nlm.nih.gov/16263283
Autor:
GEORGE M. ABOUNA, ISMAIL H. AL-ABDULLAH, DAWN KELLY-SULLIVAN, M. S. ANIL KUMAR, JEFFREY LOOSE, KIM PHILLIPS, SAMUEL YOST, DEBRA SEIRKA
Publikováno v:
Transplantation. 59(11)
Antithymocyte globulin (ATG) has been used successfully for induction therapy as well as for treatment of established allograft rejection. However, this therapy has often been associated with problems of overimmunosuppression and increased costs. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173a2a1aec0f105f1152e8c43dd02f65
https://pubmed.ncbi.nlm.nih.gov/7778170
https://pubmed.ncbi.nlm.nih.gov/7778170
Autor:
Karen M. Ward, Jeffrey S. Lizano, David A. Griffith, Robert L. Dow, John R. Hadcock, Lucinda Thiede, Rebecca E. O’Connor, Philip A. Iredale, Dennis O. Scott, Jeffrey Van Deusen, Shawn C Black, Xingrong Liu, Denise Gautreau, Dawn Kelly-Sullivan, Philip A. Carpino
Publikováno v:
BMC Pharmacology
Background Cannabinoid 1 (CB1) receptor antagonists exhibit pharmacological properties favorable for the treatment of obesity and other related metabolic disorders. CE-178253 (1-[7-(2-Chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]-[1,3,5]tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06846c41d2ee35e0dd06baa875d42637