Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Dawn Kelly"'
Publikováno v:
Cell Transplantation, Vol 4 (1995)
Transplantation of unpurified islets into the liver, unlike that of purified islets, causes portal hypertension and coagulopathy. The aim of this project was to determine the most suitable alternative site for transplantation of unpurified pancreatic
Externí odkaz:
https://doaj.org/article/f79d3f4adeaf4a06a3bab2176abb44bd
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Autor:
Natalie Mitchell, Vanessa Quinn, Keith Couper, Jean Antonelli, Lia McNamee, Janice Montgomery, Akesh Dhrampal, Alison Hall, Ronald Carrera, Henrik Reschreiter, Samantha Hendry, Stephen T. Webb, Maurizio Cecconi, Teresa Melody, Jonathan Hackett, Emer Neau, Peter Hampshire, Sarah Hierons, Gareth Sellors, Zoe Beardow, Ron Daniels, Pratik Sinha, Colette Seasman, Dawn Kelly, Carolyn S. Calfee, Katarzyna Zamoscik, Mike Gillies, Chris Smalley, Fiona Wade-Smith, Stephen G. Ward, Carole Schilling, Alexander Binning, Cecilia O'Kane, Kulwant Dhadwal, Timothy S. Walsh, Laura Youds, Lisa Sleight, Clair Harris, Pam Ramsay, Aisling Clarkson, Stephen Drage, Amy McInerney, Murthy Buddhavarapu, Kirsty Everingham, J A Wood, Daniel Martin, Kayla Harris, Corrienne McCulloch, Cliona McDowell, Griania White, Dorothy Breen, Julie Dawson, David Rogerson, Luigi Camporota, Kallirroi Kefala, John G Laffey, Brian Marsh, Archana Paikray, Lynn Gilfeather, Andrew Burtenshaw, Kevin L. Delucchi, Kate McGuigan, David Hope, Syed Farjad Sultan, Abby Brown, Sinead O'Kane, Melissa Rosbergen, Paula Meale, Daniel F. McAuley, Anna Walker, Julie Patrick-Heselton, Noel Hemmings, Sarah James, Arlo Whitehouse, Willis J Peel, Michael A. Matthay, Louise Boardman, Julie Wollaston, John G. Laffey, Sundeep Kaul, Andrew Gratrix, Paul Jefferson, Ged Dempsey, David Shaw, Alistair Nichol, Daniel Hadfield, Veronica McInerney, Ingeborg Welters, Katie Sweet, Samantha Hagan, Conor Bentley, Karen Williams, Tom Trinick, Manu Shankar-Hari, Heidi Dawson, Andrew Johnston, Stephen Graystone, Daniel McAuley, Banwari Agarwal, Julie Camsooksai, Victoria Martinson, Catherine Jardine, Andrew R Bodenham, Prashast Prashast, James O'Rourke, Clare Mellis, Fang Gao, Craig Morris, Neil Young, Steven Henderson, Victoria Waugh, Christopher Danbury, Yongyan Qui, Georgina Parsons, Catherine Leonard, Neil Smith, Timothy Gould, Molly Chibvuri, Nicola Jacques, Sinead Helyar, Matthew Thomas, Sarah Casboult, Lukas Pokorny, Alan Davidson, Naomi Hickey, Rachael Bennett, Joanne Thompson, Orla O'Neill, Elizabeth Lemon, Paul Johnston, Cat Yates, John Trinder, Gavin Nicol, Jacqueline Baldwin, Johannes Mellinghoff, Philip Hopkins, Julian Hull, Helena Barcraft-Barnes, Lee Poole, Fiona Bottrill, Jessica Thrush, Anissa Benchiheub, Stuart Elliot, Fiona Pollock, Lauren Cooper, Grant Price, Teresa Martin, Leona Bannon, Sian Birch, Reni Jacob, Terry Martin, Gavin D. Perkins, Geraldine Ward, Donal Ryan, Esther Price, Petra Polgarova, Agnieszka Walecka, Katie Lei, Chris Nutt, Christopher Bassford, Laura Ortiz-Ruiz de Gordoa, Irfan Chaudry, Stephen E Wright
Publikováno v:
Irish Critical Care Trials Group 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial ', The Lancet Respiratory Medicine, vol. 6, no. 9, pp. 691-698 . https://doi.org/10.1016/S2213-2600(18)30177-2
Calfee, C, Delucchi, K, Sinha, P, Matthay, M, Hackett, J, Shankar-Hari, M, McDowell, C, G. Laffey, J, O’Kane, C & McAuley, D F 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin : Secondary Analysis of a Randomized Controlled Trial ', The lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(18)30177-2
Calfee, C, Delucchi, K, Sinha, P, Matthay, M, Hackett, J, Shankar-Hari, M, McDowell, C, G. Laffey, J, O’Kane, C & McAuley, D F 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin : Secondary Analysis of a Randomized Controlled Trial ', The lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(18)30177-2
Background: Precision medicine approaches targeting patients based on disease subtype have transformed approaches to cancer, asthma, and other heterogeneous syndromes. Two distinct subphenotypes of ARDS have been identified in three US-based clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383abcee6e51fb6ddb26ecb8bba26152
https://pure.qub.ac.uk/en/publications/acute-respiratory-distress-syndrome-subphenotypes-and-differential-response-to-simvastatin-secondary-analysis-of-a-randomised-controlled-trial(a0bb28cb-71b1-4ff0-b64d-387bd1418815).html
https://pure.qub.ac.uk/en/publications/acute-respiratory-distress-syndrome-subphenotypes-and-differential-response-to-simvastatin-secondary-analysis-of-a-randomised-controlled-trial(a0bb28cb-71b1-4ff0-b64d-387bd1418815).html
Autor:
Jimmy Kong, Theunis C. Goosen, Kimberly O. Cameron, Samit Kumar Bhattacharya, Suvi T. M. Orr, Dilinie P. Fernando, Peter Cornelius, Eunsun Lee, Meihua Tu, Stefanus J. Steyn, David Austen Perry, Laura Michael, Jana Polivkova, Ann M. Janssen, Margaret Jackson, Jeffrey T. Kohrt, Ruduan Wang, Sylvie Perez, Hirokazu Ueno, Kimberly Lapham, Dawn Kelly-Sullivan, Victoria Bagdasarian, Roger Swartz, Ingrid A. Stock, Yingxin Zhang, Ryan Jones, Erasga Noe Ouano, Kim F. McClure, Wenhua Jiao, Daniel W. Kung, Guoqiang Wang, Hua Gao, Sam Varma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5410-5414
The optimization for selectivity and central receptor occupancy for a series of spirocyclic azetidine-piperidine inverse agonists of the ghrelin receptor is described. Decreased mAChR muscarinic M2 binding was achieved by use of a chiral indane in pl
Autor:
Rebecca E. O’Connor, Steven R. Schneider, Denise Gautreau, Philip A. Carpino, Karen M. Ward, Jeffrey S. Lizano, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Robert L. Dow, Dawn Kelly-Sullivan
Publikováno v:
ACS Medicinal Chemistry Letters. 3:397-401
Antagonism of cannabinoid-1 (CB1) receptor signaling has been demonstrated to inhibit feeding behaviors in humans, but CB1-mediated central nervous system (CNS) side effects have halted the marketing and further development of the lead drugs against
Autor:
Dawn Kelly, David A. Steen
Publikováno v:
Ecology. 98:1727-1728
Autor:
Karen Siegel, Helen Kim Cho, David Looper, Shawn C Black, Xiao-Hong Yu, Scott Rp McDonnell, Dawn Kelly-Sullivan, Sergei Timofeevski, Junming Yie, Celia P. Briscoe, Kathleen M. Ogilvie, Ping Chen, Manli Shi, James S. Fraser
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E1142-E1151
c-Jun NH2-terminal kinase (JNK) plays an important role in insulin resistance; however, identification of pharmacologically potent and selective small molecule JNK inhibitors has been limited. Compound A has a cell IC50 of 102 nM and is at least 100-
Autor:
Dawn Kelly, Karen Elcock
Publikováno v:
Nursing Standard. 21:44-47
Publikováno v:
Scopus-Elsevier
This article describes one university's efforts to provide support for mentors in clinical practice by introducing learning community education advisers. It outlines the role of these advisers and its application in practice, particularly in regard t
Publikováno v:
European Journal of Pharmacology. 462:125-132
We determined the effect of a cannabinoid CB1 receptor antagonist (AM-251; N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) on food intake, body weight and adipose tissue mass in Western diet-induced obes