Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Dawn Jaquish"'
Autor:
Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wahl
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189051 (2017)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and bec
Externí odkaz:
https://doaj.org/article/23aab20296124703a94f74164e9e8040
Autor:
Andrew M. Lowy, Marco Gymnopoulos, Hervé Tiriac, Alexis A. Wascher, Eric Wong, Dawn Jaquish, Evangeline S. Mose, Edgar Esparza, Oscar Betancourt, Alex Cazes
Purpose:Pancreatic cancer is an aggressive disease associated with a poor 5-year overall survival. Most patients are ineligible for surgery due to late diagnosis and are treated primarily with chemotherapy with very limited success. Pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556bc0a604563eb965278ad8ebc346b1
https://doi.org/10.1158/1078-0432.c.6530867
https://doi.org/10.1158/1078-0432.c.6530867
Autor:
Andrew M. Lowy, Marco Gymnopoulos, Hervé Tiriac, Alexis A. Wascher, Eric Wong, Dawn Jaquish, Evangeline S. Mose, Edgar Esparza, Oscar Betancourt, Alex Cazes
MET expression in pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d2163ee84448114b8db94c4cb12811
https://doi.org/10.1158/1078-0432.22482251.v1
https://doi.org/10.1158/1078-0432.22482251.v1
Autor:
Sohini Khan, Shweta Sharma, Divya Sood, Bharti Garg, Dawn Jaquish, Evangeline Mose, Edgar Esparza, Herve Tiriac, Andrew M. Lowy
Publikováno v:
Cancer Research. 82:B017-B017
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer in large part due to its propensity for early metastasis. We used ChIP-seq to identify differentially tagged super-enhancer associated genes in PDAC and identified MICAL2 as a g
Autor:
Siming Sun, Jay Patel, Alexis Wascher, Evangeline S. Mose, Dawn Jaquish, Spencer Brightman, Stephen Schoenberger, Andrew M. Lowy, Tatiana Hurtado de Mendoza
Publikováno v:
Cancer Research. 82:C021-C021
Immunotherapy has become a standard of care treatment for many cancer types. Anti-tumor immune responses are elicited against neoantigens that arise from genetic alterations within tumor cells, and high tumor mutational burden increases the likelihoo
Autor:
Chih-Min Tang, Phillippe Foubert, Evangeline Mose, Andrew M. Lowy, Dawn Jaquish, Michele L. Babicky, Megan M. Harper, Alex Cazes, Michael C. Schmid, Karen Messer, Patrick Holman, Randall French, Jaclyn Miyamoto, Susan E. Waltz, Judith A. Varner, Zakkary J Walterscheid, Jeffery Chakedis, Nissi Varki, Hakan Alakus, Betzaira G. Childers, Jason K. Sicklick
Publikováno v:
ONCOGENE
Oncogene, vol 38, iss 28
Oncogene
Oncogene, vol 38, iss 28
Oncogene
The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined the relevance of Mst1r kinase to Kras driven pancreatic carcinogenesis using genetically eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbd059e2304724657496e421fcd5c30
Autor:
Paula Porras, Zakk Walterscheid, Dawn Jaquish, Jan Eickhoff, Michele L. Babicky, Evangeline Mose, Jeffery Chakedis, Andrew M. Lowy, Peter Cheng, Carsten Schultz-Fademrecht, Oliver Schadt, Randall French, Haleigh Howard, Christina Esdar, Jaclyn Miyamoto, Patrick Holman
Publikováno v:
Oncotarget
// Jeffery Chakedis 1 , Randall French 1 , Michele Babicky 1 , Dawn Jaquish 1 , Evangeline Mose 1 , Peter Cheng 1 , Patrick Holman 1 , Haleigh Howard 1 , Jaclyn Miyamoto 1 , Paula Porras 1 , Zakk Walterscheid 1 , Carsten Schultz-Fademrecht 2 , Christ
Publikováno v:
Cancer Research. 79:A07-A07
Background: RON/MST1R is a receptor tyrosine kinase variably expressed in epithelial cells and macrophages and overexpressed in epithelial cancers. It is involved in downstream signaling pathways that regulate cell survival, proliferation, and invasi
Autor:
Dawn Jaquish, Evangeline Mose, Raymond W. Lam, Jaclyn Miyamoto, Jeffery Chakedis, Randall French, Patrick Holman, Andrew M. Lowy, Haleigh Howard, Zakk Walterscheid, Michele L. Babicky
Publikováno v:
Oncogene, vol 35, iss 25
Oncogene
Oncogene
The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3922ee8401d48590dec6ebd96cb8dd48
https://escholarship.org/uc/item/1q16t7ct
https://escholarship.org/uc/item/1q16t7ct
Autor:
David A. Cheresh, Peter T. Yu, Heather Hoover, Karly Marayuma, Benjamin F. Cravatt, Andrew M. Lowy, Sherry Niessen, R. French, Evangeline Mose, Michele L. Babicky, Dawn Jaquish, David J. Shields
Publikováno v:
International Journal of Cancer. 131:1744-1754
The recepteur d'origine nantais (RON) receptor tyrosine kinase is overexpressed and stimulates invasive growth in pancreatic cancer cells, yet the mechanisms that underlie RON-mediated phenotypes remain poorly characterized. To better understand RON