A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity

Autor: Leela Phadke, Dawn H. W. Lau, Nozie D. Aghaizu, Shania Ibarra, Carmen M. Navarron, Lucy Granat, Lorenza Magno, Paul Whiting, Sarah Jolly

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

Neuroinflammation and hyperexcitability have been implicated in the pathogenesis of neurodegenerative disease, and new models are required to investigate the cellular crosstalk involved in these processes. We developed an approach to generate a quant

Externí odkaz: https://doaj.org/article/26e4f8acc7a040ddae3f13c8c6b77955

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

Autor: Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)

Abstract Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for

Externí odkaz: https://doaj.org/article/c1a67a677a2d464dac0f9c9c50fcb0e5

Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis

Autor: Naomi Hartopp, Dawn H W. Lau, Sandra M. Martin-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Jenny Greig, Elizabeth B. Glennon, Claire Troakes, Patricia Gomez-Suaga, Wendy Noble, Christopher C.J. Miller

Publikováno v: Frontiers in cell and developmental biology. 10

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation to ER-mitochondria signaling is seen in cell and transgenic models of ALS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c9c31fa7d06a18fcb528f88430624f
https://pubmed.ncbi.nlm.nih.gov/36051435

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein

Autor: Nadine Muschalik, Dawn H. W. Lau, Jenny Greig, Gábor M. Mórotz, Elizabeth B. Glennon, Francesca Mattedi, Alessio Vagnoni, Wendy Noble, Nishita Bhembre, Christopher C.J. Miller

Publikováno v: Mórotz, G M, Glennon, E B, Greig, J, Lau, D H W, Bhembre, N, Mattedi, F, Muschalik, N, Noble, W, Vagnoni, A & Miller, C C J 2019, ' Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein ', Acta Neuropathologica Communications, vol. 7, no. 1, 200 . https://doi.org/10.1186/s40478-019-0857-5
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)

Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, altered APP pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c59c7dcaad7bf991f2fddb1941fd4a
https://kclpure.kcl.ac.uk/ws/files/148224846/Kinesin_light_chain_1_serine_460_VAGNONI_Publishedonline5December2019_GOLD_VoR_CC_BY_.pdf

Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain

Autor: Claire Troakes, Gábor M. Mórotz, Dawn H. W. Lau, Sebastien Paillusson, Naomi Hartopp, Patricia Gomez-Suaga, Jenny Greig, Christopher C.J. Miller, Wendy Noble, Huzefa Rupawala

Publikováno v: Neurobiology of Disease
Lau, D H W, Paillusson, S, Hartopp, N, Rupawala, H, Mórotz, G M, Gomez-Suaga, P, Greig, J, Troakes, C, Noble, W & Miller, C C J 2020, ' Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain ', Neurobiology of Disease, vol. 143, NBD-20-191R1, pp. 1-25 . https://doi.org/10.1016/j.nbd.2020.105020
Neurobiology of Disease, Vol 143, Iss, Pp 105020-(2020)

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions, many of which are perturbed in Alzheimer's disease. Moreover, damage to ER-mitochondria signaling is seen in cell and transgenic models of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc0cadec97f07874c832dedd8283411
https://doi.org/10.1016/j.nbd.2020.105020