Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dawn E. Comstock"'
Autor:
Elena Battistello, Kimberlee Hixon, Dawn E. Comstock, Clayton K. Collings, Xufeng Chen, Javier Rodriguez Hernaez, Soobeom Lee, Konstantinos Ntatsoulis, Annamaria Cesarano, Kathryn Hockemeyer, W. Nicholas Haining, Matthew T. Witkowski, Jun Qi, Aristotelis Tsirigos, Fabiana Perna, Ioannis Aifantis, Cigall Kadoch
Publikováno v:
Cancer Research. 83:1794-1794
T cell activation and exhaustion are associated with highly coordinated changes in gene expression and chromatin accessibility. While the contribution of key, state-specific transcription factors to these processes has been extensively explored, the
Autor:
Elena Battistello, Kimberlee A. Hixon, Dawn E. Comstock, Clayton K. Collings, Xufeng Chen, Javier Rodriguez Hernaez, Soobeom Lee, Kasey S. Cervantes, Madeline M. Hinkley, Konstantinos Ntatsoulis, Annamaria Cesarano, Kathryn Hockemeyer, W. Nicholas Haining, Matthew T. Witkowski, Jun Qi, Aristotelis Tsirigos, Fabiana Perna, Iannis Aifantis, Cigall Kadoch
Publikováno v:
Molecular Cell. 83:1216-1236.e12
Autor:
Scott J. Rodig, Girish S. Naik, Evisa Gjini, Arpit Panda, Kevin Bi, Seth Maleri, Gabriel K. Griffin, W. Nicholas Haining, Martin W. LaFleur, Sarah A. Weiss, Margaret D. Zimmer, Kristen Felt, Robert T. Manguso, Arlene H. Sharpe, F. Stephen Hodi, Yamini V. Virkud, Jeffrey J. Ishizuka, Jenna L. Collier, Ana Lako, Debattama R. Sen, Juhi R. Kuchroo, Michael Manos, Rose Al Abosy, Brian C. Miller, Kathleen B. Yates, Flavian D. Brown, Dawn E. Comstock
Publikováno v:
Nat Immunol
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood. Here we show that such th
Autor:
John G. Doench, Flavian D. Brown, Dawn E. Comstock, Kathleen B. Yates, Juan Dubrot, Robert T. Manguso, Hans W. Pope, W. Nicholas Haining, Austin Ayer, Adrienne H. Long, Arpit Panda, Ian C. Kohnle, Peter P. Du, Margaret D. Zimmer, Erez Y. Levanon, Jeffrey J. Ishizuka, Gabriel K. Griffin, Sarah Kate Lane-Reticker, Kevin Bi, David Kozono, Ilana Buchumenski, Natalie B. Collins, Collins K. Cheruiyot, Brian C. Miller, Emily J. Robitschek, Debattama R. Sen, Arvin Iracheta-Vellve
Publikováno v:
Signal Transduction and Targeted Therapy
Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tum
Autor:
Andre Lima Queiroz, Mathilda Eriksson, Erik Norberg, Yuqing Hao, Boxi Zhang, Per Hydbring, Dawn E. Comstock, Helin Vakifahmetoglu-Norberg
Publikováno v:
Biochemical and Biophysical Research Communications. 499:314-320
Malate Dehydrogenase (MDH) 1 has recently been shown to be highly expressed and display prognostic value in non-small cell lung carcinomas (NSCLCs). However, it is not known how MDH1 expression is regulated and there is no current molecular or chemic
Autor:
Roodolph St. Pierre, Lee Barrett, Clifford J. Woolf, Tom W. Muir, Hai T. Dao, Alfredo M. Valencia, Olubusayo Bolonduro, Zoe C. Yeoh, Clayton K. Collings, Crystal Hermawan, Cigall Kadoch, Yung-Chih Cheng, Zhen-Yu Sun, Mary K. Dornon, Nicholas E. Vangos, Dawn E. Comstock, Hyuk-Soo Seo, Sirano Dhe-Paganon, Nazar Mashtalir, Junwei Huang
Publikováno v:
Cell
Summary Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain-specific contributions to complex activities is needed to advance mechanisti
Autor:
Gabriel K. Griffin, Kathleen B. Yates, F. Stephen Hodi, Kevin Bi, Sarah A. Weiss, Seth Maleri, Robert T. Manguso, Arlene H. Sharpe, Yamini V. Virkud, Evisa Gjini, Kristen Felt, Scott J. Rodig, Debattama R. Sen, Flavian D. Brown, Dawn E. Comstock, Martin W. LaFleur, Brian C. Miller, Rose Al Abosy, Jeffrey J. Ishizuka, W. Nicholas Haining, Jenna L. Collier, Margaret D. Zimmer, Ana Lako, Arpit Panda, Girish S. Naik, Juhi R. Kuchroo, Michael Manos
Publikováno v:
Nature Immunology. 20:1556-1556
Publikováno v:
JAMA Oncology. 3:703