Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dawn E. Cohen"'
Autor:
Guilong Charles Cheng, Neil F. Langille, Alicia Zeng, Jenil Patel, Chris Scardino, Travis Anthoine, William E. Lake, Scott W. Roberts, Matthew G. Beaver, John L. Tucker, Shawn D. Walker, Dawn E. Cohen, William Powazinik, Peter K. Dornan, Sheng Cui, Simone Spada, Susan P. Lucas
Publikováno v:
Organic Process Research & Development. 24:481-489
Epoxyketone 4 is an isolated intermediate in the manufacturing route to the commercial proteasome inhibitor carfilzomib (Kyprolis). Commercial process development and optimization efforts toward th...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d83d0a8ad40e0186b29fa7df348a5b2
https://doi.org/10.1021/acs.oprd.0c00051
https://doi.org/10.1021/acs.oprd.0c00051
Autor:
Carl Davis, Qiong Wu, Oliver R. Thiel, Robert R. Milburn, Jodi L. Liu, Y.-H. Kiang, Eric A. Bercot, Christopher J. Borths, Robert E. Saw, Dawn E. Cohen, Richard J. Staples
Publikováno v:
Organic Process Research & Development. 19:1849-1858
AMG 579 (1) is a potent and selective phosphodiesterase 10 (PDE10A) inhibitor selected for clinical development for the treatment of schizophrenia. Extensive polymorph and salt screening identified two free-base anhydrous polymorphs (Form 1 and Form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b06eaa6b031c67cb79c311ae7587d8
https://doi.org/10.1021/acs.oprd.5b00031
https://doi.org/10.1021/acs.oprd.5b00031
Publikováno v:
Organic Process Research & Development. 18:1807-1811
The safe implementation of a hydrogen-peroxide-mediated oxidation of a poorly reactive sulfide to the corresponding sulfone is described. A three-tiered approach incorporating process understanding, safety studies, and real time PAT (in situ Raman sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c8c5eac9e4388d70831fe47e1c93ae
https://doi.org/10.1021/op500132s
https://doi.org/10.1021/op500132s
Autor:
Scott W. Roberts, Stephen M. Shaw, Joe Tomaskevitch, Oliver R. Thiel, Dawn E. Cohen, Justin T. Tvetan, Jacqueline E. Milne
Publikováno v:
Organic Process Research & Development. 16:2058-2063
The Ritter reaction utilizing tert-butyl acetate as the tert-butyl cation source was investigated by in situ FTIR and calorimetry under various reaction conditions. It was established that, when a batch mode reaction in acetic acid was performed, min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5d46266209bcc8932b4e5d6fa1ac4d5
https://doi.org/10.1021/op3000042
https://doi.org/10.1021/op3000042
Publikováno v:
Analytical Chemistry. 82:5707-5717
This paper describes a very simple and robust microfluidic device for digitizing samples into an array of discrete volumes. The device is based on an inherent fluidic phenomenon, where an incoming aqueous sample divides itself into an array of chambe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714f44598cf0e7f72ed19e459ceda227
https://doi.org/10.1021/ac100713u
https://doi.org/10.1021/ac100713u
Autor:
Philip J. Reid, Jingdong Luo, Neil M. Tucker, Marnie Haller, Dawn E. Cohen, Bart Kahr, Alex K.-Y. Jen, Kimberly A. Firestone, Egbert Zojer, Amalia Leclercq, David B. Lao, Werner Kaminsky, Sei Hum Jang, Tae-Dong Kim, Larry R. Dalton, Jae-Wook Kang, Jason B. Benedict, Denise H. Bale, Jean-Luc Brédas
Publikováno v:
Chemistry of Materials. 18:2982-2988
We have synthesized a new class of highly efficient nonlinear optical (NLO) chromophores based on the novel tricyanopyrroline (TCP) electron acceptor. Molecular linear and nonlinear optical properties of the prototypical chromophores were measured an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f01e2dd089c931ff2024cfd37cfc10
https://doi.org/10.1021/cm052861i
https://doi.org/10.1021/cm052861i
Autor:
Thomas J. Crevier, Ahmad Dehestani, Dawn E. Cohen, Werner Kaminsky, James M. Mayer, Adam Wu, Erik Saganic
Publikováno v:
Inorganica Chimica Acta. 359:2842-2849
The reaction between TpOs(N)Cl2 (1) [Tp = hydrotris(1-pyrazolyl)borate] and aqueous (nBu4N)(OH) in THF-d8 forms the nitrosyl complex TpOs(NO)Cl2 (5) among other products, suggesting an initial hydroxide attack at the nitrido ligand. In contrast, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833fe386fbbec15d217accea13e4ed44
https://doi.org/10.1016/j.ica.2005.11.033
https://doi.org/10.1016/j.ica.2005.11.033
Publikováno v:
Journal of the American Chemical Society. 128:5548-5559
The concept of syncrystallization was reinvestigated by focusing on phthalic acid (PA) grown with methyl red (MR). Crystals are alternately red and yellow in adjacent growth sectors. X-ray structures of MR and its cocrystals, revealing MR in the neut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651abf6cc9ad9e0d9b195f1c189fb9ad
https://doi.org/10.1021/ja0601181
https://doi.org/10.1021/ja0601181
Autor:
Dawn E. Cohen, Charles DeBrosse, Grant P. Spoors, Joshua D. Bowman, Philip C. Dell'orco, R. Curtis Haltiwanger, Gary E. Zuber, Gudrun A. Trescher, Lee M. Katrincic, Frederick G. Vogt
Publikováno v:
Journal of pharmaceutical sciences. 94(3)
Five polymorphic forms of tranilast were characterized by thermal, diffractometric, and spectroscopic techniques. The crystal structures of the most stable anhydrous form (Form I), a chloroform solvate, and a dichloromethane solvate were determined f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf37c8fd6d5ceab784bb395faa67fc71
https://pubmed.ncbi.nlm.nih.gov/15666296
https://pubmed.ncbi.nlm.nih.gov/15666296
Publikováno v:
Crystal Growth & Design; Mar2007, Vol. 7 Issue 3, p492-495, 4p