Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dawn E. Beachy"'
Autor:
Justin S. Bickford, Dawn E. Beachy, Kimberly J. Newsom, Sarah J. Barilovits, John-David H. Herlihy, Xiaolei Qiu, Jewell N. Walters, Ning Li, Harry S. Nick
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1915-1926 (2013)
Specific control of group IVA cytosolic phospholipase A2 (cPLA2α or PLA2G4A) expression modulates arachidonic acid production, thus tightly regulating the downstream effects of pro- and anti-inflammatory eicosanoids. The significance of this pathway
Externí odkaz:
https://doaj.org/article/49f9fca063b042978171b876bd5e3170
Autor:
Richard A. Oram, Helmut Hiller, Joeseph J. Lebowitz, Habibeh Khoshbouei, Irina Kusmarteva, Mark A. Atkinson, Bernd Bodenmiller, Desmond A. Schatz, Dawn E. Beachy, Amanda L. Posgai, Douglas R. Miller, Clive Wasserfall, Justin Mason, Andrew T. Hattersley, Laura M. Jacobsen, Stefanie Engler, Harry S. Nick
Publikováno v:
Diabetes
Diabetes, 70 (8)
Diabetes, 70 (8)
Type 1 diabetes (T1D) has a multifactorial autoimmune etiology, involving environmental prompts and polygenic predisposition. We hypothesized that pancreata from individuals with and at risk for T1D would exhibit dysregulated expression of genes asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295eb2ed3df8f0a6b34d70ed66133d34
https://doi.org/10.5167/uzh-211581
https://doi.org/10.5167/uzh-211581
Autor:
Amanda L. Posgai, Harry S. Nick, Eduardo Candelario-Jalil, Clive Wasserfall, Mark A. Atkinson, Desmond A. Schatz, Dawn E. Beachy, Irina Kusmartseva, Changjun Yang, Helmut Hiller
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Normal cellular prion protein (PrP(C)) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a glycophosphatidylinositol anchor. Although PrP(C) is expressed by a wide range of tissues throughout th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7a151ddfd0fce96beea01429fb4d75
https://europepmc.org/articles/PMC8715394/
https://europepmc.org/articles/PMC8715394/
Autor:
Dawn E. Beachy, Brittany S. Bruggeman, Harry S. Nick, Clive Wasserfall, Mark A. Atkinson, Desmond A. Schatz, Laura M. Jacobsen
Publikováno v:
Diabetes. 69
Current evidence suggests that alteration in cellular metabolism leads to pancreatic β-cell dysfunction and loss in type 1 diabetes (T1D). The mammalian target of rapamycin, mTOR is a key regulator of cell survival and growth in response to intracel
Autor:
Harry S. Nick, Kimberly J. Newsom, Dawn E. Beachy, Sarah J. Barilovits, Ann L. Chokas, Richard J. Rogers, Xiaolei Qiu, Justin S. Bickford
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1839:1205-1216
Manganese superoxide dismutase (MnSOD), a critical anti-oxidant enzyme, detoxifies the mitochondrial-derived reactive oxygen species, superoxide, elicited through normal respiration or the inflammatory response. Proinflammatory stimuli induce MnSOD g
Autor:
Dawn E. Beachy, Benjamin Keeler, Terence R. Flotte, Christian Mueller, John-David Herlihy, Harry S. Nick, Kimberly J. Newsom, Justin S. Bickford, Sarah J. Barilovits
Publikováno v:
Journal of Cystic Fibrosis. 12(3):258-265
BackgroundAllergic bronchopulmonary aspergillosis (ABPA) is a complicating factor in cystic fibrosis (CF), affecting 2–15% of patients. We hypothesized that sensitization/challenge of CFTR−/− mice with an Aspergillus fumigatus (Af) extract will
Autor:
Demaretta S. Rush, Harry S. Nick, Alice Rhoton-Vlasak, Sarah J. Barilovits, Dawn E. Beachy, Helen Paige Swenson
Publikováno v:
Obstetrics & Gynecology. 131:2S-2S
INTRODUCTION:To assess FOXO3 gene expression levels and members of the KL-PI3K-AKT-FOXO3 pathway in pre- and postmenopausal human ovaries. To evaluate in a temporal manner protein localization of FOXO3 in pre- and postmenopausal human ovaries by immu
Publikováno v:
Journal of Biological Chemistry. 283:25774-25785
The mitochondrial antioxidant enzyme manganese superoxide dismutase (Mn-SOD) is crucial in maintaining cellular and organismal homeostasis. Mn-SOD expression is tightly regulated in a manner that synchronizes its cytoprotective functions during infla
Autor:
Maria Beery, Ezio Bonifacio, Harry S. Nick, Clive Wasserfall, Amanda L. Posgai, Peter Arvan, Christopher J. Rhodes, Irina Kusmartseva, Dawn E. Beachy, Leena Haataja, Mark A. Atkinson, Martha Campbell-Thompson
Publikováno v:
Cell Metabolism. 26:568-575.e3
Summary The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β cells has recently been questioned as small amounts of C-peptide are detectable in patients with long-standing disease. We analyzed protein and gen
Autor:
Michael F. Waters, Harry S. Nick, Justin S. Bickford, Musab Al-Yahia, Dawn E. Beachy, Jerelyn A. Nick, Sylvain Doré, Narjis F. Ali
Publikováno v:
Brain research. 1588
Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemor