Výsledky vyhledávání - "Dawn E Watkins-Chow"

Akademický článek

A Sox10 expression screen identifies an amino acid essential for Erbb3 function.

Autor: Kristina Buac, Dawn E Watkins-Chow, Stacie K Loftus, Denise M Larson, Arturo Incao, Gretchen Gibney, William J Pavan

Publikováno v: PLoS Genetics, Vol 4, Iss 9, p e1000177 (2008)

The neural crest (NC) is a population of embryonic stem cells that gives rise to numerous cell types, including the glia and neurons of the peripheral and enteric nervous systems and the melanocytes of the skin and hair. Mutations in genes and geneti

Externí odkaz: https://doaj.org/article/7dd9a467d33b4fa0a10ffa5c6de6125d

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Akademický článek

Correlation of age of onset and clinical severity in Niemann–Pick disease type C1 with lysosomal abnormalities and gene expression

Autor: Laura L. Baxter, Dawn E. Watkins-Chow, Nicholas L. Johnson, Nicole Y. Farhat, Frances M. Platt, Ryan K. Dale, Forbes D. Porter, William J. Pavan, Jorge L. Rodriguez-Gil

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Niemann–Pick disease type C1 (NPC1) is a rare, prematurely fatal lysosomal storage disorder which exhibits highly variable severity and disease progression as well as a wide-ranging age of onset, from perinatal stages to adulthood. This he

Externí odkaz: https://doaj.org/article/ca15cd7d85e544589362b1541d47b189

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Akademický článek

Identification of Gene Variants Associated with Melanocyte Stem Cell Differentiation in Mice Predisposed for Hair Graying

Autor: Allison C. Fialkowski, Denise J. Levy, Dawn E. Watkins-Chow, Joseph W. Palmer, Roshan Darji, Hemant K. Tiwari, William J. Pavan, Melissa L. Harris

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 817-827 (2019)

Age-related hair graying is caused by malfunction in the regenerative potential of the adult pigmentation system. The retention of hair color over the life of an organism is dependent on the ability of the melanocyte stem cells and their progeny to p

Externí odkaz: https://doaj.org/article/98f33d8c9a2b420c95078b480dc26bed

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Akademický článek

Highly Efficient Cpf1-Mediated Gene Targeting in Mice Following High Concentration Pronuclear Injection

Autor: Dawn E. Watkins-Chow, Gaurav K. Varshney, Lisa J. Garrett, Zelin Chen, Erin A. Jimenez, Cecilia Rivas, Kevin S. Bishop, Raman Sood, Ursula L. Harper, William J. Pavan, Shawn M. Burgess

Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 2, Pp 719-722 (2017)

Cpf1 has emerged as an alternative to the Cas9 RNA-guided nuclease. Here we show that gene targeting rates in mice using Cpf1 can meet, or even surpass, Cas9 targeting rates (approaching 100% targeting), but require higher concentrations of mRNA and

Externí odkaz: https://doaj.org/article/89683c74cd5d49d182e18109a69beb4d

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