Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Dawn E Saunders"'
Autor:
Russell Murdoch, Hanne Stotesbury, Jamie M. Kawadler, Dawn E. Saunders, Fenella J. Kirkham, Karin Shmueli
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Silent cerebral infarction (SCI) is the most commonly reported radiological abnormality in patients with sickle cell anemia (SCA) and is associated with future clinical stroke risk. To date, there have been few histological and quantitative MRI studi
Externí odkaz:
https://doaj.org/article/0386882caad3453f806e200873d28ed0
Autor:
Hanne Stotesbury, Jamie M. Kawadler, Jonathan D. Clayden, Dawn E. Saunders, Anna M. Hood, Melanie Koelbel, Sati Sahota, David C. Rees, Olu Wilkey, Mark Layton, Maria Pelidis, Baba P. D. Inusa, Jo Howard, Subarna Chakravorty, Chris A. Clark, Fenella J. Kirkham
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Research in sickle cell anemia (SCA) has used, with limited race-matched control data, binary categorization of patients according to the presence or absence of silent cerebral infarction (SCI). SCI have primarily been identified using low-resolution
Externí odkaz:
https://doaj.org/article/b9b954bad2e74950bfb278ad5b115405
Autor:
Hanne Stotesbury, Patrick W. Hales, Anna M. Hood, Melanie Koelbel, Jamie M. Kawadler, Dawn E. Saunders, Sati Sahota, David C. Rees, Olu Wilkey, Mark Layton, Maria Pelidis, Baba P. D. Inusa, Jo Howard, Subarna Chakravorty, Chris A. Clark, Fenella J. Kirkham
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Previous studies have pointed to a role for regional cerebral hemodynamic stress in neurological complications in patients with sickle cell anemia (SCA), with watershed regions identified as particularly at risk of ischemic tissue injury. Using singl
Externí odkaz:
https://doaj.org/article/72f7c88f701c47aea7fb2b9583d683dc
Autor:
Mboka Jacob, Jamie M. Kawadler, Russell Murdoch, Magda Ahmed, Hilda Tutuba, Upendo Masamu, Karin Shmueli, Dawn E. Saunders, Chris A. Clark, Jinna Kim, Shifa Hamdule, Julie Makani, Hanne Stotesbury, Fenella J. Kirkham
Publikováno v:
British Journal of Haematology. 201:114-124
Brain injury is a common complication of sickle cell anaemia (SCA). White matter (WM) and cortical and subcortical grey matter (GM), structures may have reduced volume in patients with SCA. This study focuses on whether silent cerebral infarction (SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4479d56a3dae4ca1c53e15ec81a90e83
https://doi.org/10.1111/bjh.18503
https://doi.org/10.1111/bjh.18503
Autor:
Hanne Stotesbury, Jamie M. Kawadler, Patrick W. Hales, Dawn E. Saunders, Christopher A. Clark, Fenella J. Kirkham
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
It is well-established that patients with sickle cell disease (SCD) are at substantial risk of neurological complications, including overt and silent stroke, microstructural injury, and cognitive difficulties. Yet the underlying mechanisms remain poo
Externí odkaz:
https://doaj.org/article/a38487b6add14a4591bfdaf0e78f94f8
Autor:
Hanne Stotesbury, Patrick W Hales, Melanie Koelbel, Anna M Hood, Jamie M Kawadler, Dawn E Saunders, Sati Sahota, David C Rees, Olu Wilkey, Mark Layton, Maria Pelidis, Baba PD Inusa, Jo Howard, Subarna Chakravorty, Chris A Clark, Fenella J Kirkham
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:1061-1077
Prior studies have described high venous signal qualitatively using arterial spin labelling (ASL) in patients with sickle cell anemia (SCA), consistent with arteriovenous shunting. We aimed to quantify the effect and explored cross-sectional associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d47b62bfa98be4dda6083460340d6c7
https://doi.org/10.1177/0271678x211072391
https://doi.org/10.1177/0271678x211072391
Publikováno v:
Expert Review of Hematology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Introduction: Over the past decades, neuroimaging studies have clarified that a significant proportion of patients with sickle cell disease (SCD) have functionally significant brain abnormalities. Clinically, structural magnetic resonance imaging (MR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2142db19d199c98ee2bd8ab3d02ef3d5
https://doi.org/10.1080/17474086.2021.1893687
https://doi.org/10.1080/17474086.2021.1893687
Autor:
Paul A. Brogan, Madeleine J. Tooley, Ruth Newbury-Ecob, Annette Keylock, Barbara Jensen, Ying Hong, Hywel Williams, Andrew A Mallick, Ebun Omoyinmi, Olumide Ogunbiyi, Vijeya Ganesan, Thomas S. Jacques, Julia Rankin, Despina Eleftheriou, Dawn E. Saunders
Publikováno v:
Neurology: Genetics
ObjectiveTo report a series of patients with cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma (CBL) gene and examine the functional role of the identified mutant Cbl protein. We hypothesized that mutated C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c23e25550c11077b9a4e2ccfbf12bae
https://orca.cardiff.ac.uk/id/eprint/142890/1/e448.full.pdf
https://orca.cardiff.ac.uk/id/eprint/142890/1/e448.full.pdf
Autor:
Raphael Z. Sangeda, Dawn E. Saunders, Julie Makani, Ramadhan Kazema, Fenella J. Kirkham, Clara Chamba, Hanne Stotesbury, Chris A. Clark, Winok Lapadaire, Jamie M. Kawadler, Mboka Jacob
Publikováno v:
Stroke. 51(4)
Background and Purpose— Widespread reductions in white matter integrity are associated with cognitive dysfunction in sickle cell anemia. Silent cerebral infarction (SCI), vasculopathy (VSC), and low hemoglobin concentration (Hb) are implicated; we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d39ed8172d4363043afb0395ebbd30
https://pubmed.ncbi.nlm.nih.gov/32138633
https://pubmed.ncbi.nlm.nih.gov/32138633
Autor:
Fenella J. Kirkham, Hilda Tutuba, Edward Kija, Magda Ahmed, Karin Shmueli, Balowa Mussa, Siana Nkya, Furahini Tluway, Frank Kussaga, Angela Darekar, Julie Makani, Russell Murdoch, Mboka Jacob, Jamie M. Kawadler, Winok Lapidaire, Ramadhan Kazema, Lulu Fundikira, Chris A. Clark, Dawn E. Saunders
Publikováno v:
Blood Advances. 2:26-29
Sickle cell anemia neurologic complications The collaboration aims at exploring the relationship between the cerebral vasculature and neurologic complications in Tanzanian children with sickle cell anemia (SCA). Cerebral vasculopathy in internal caro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a5f2a61b1654686f47d99d8bca5c69
https://doi.org/10.1182/bloodadvances.2018gs112714
https://doi.org/10.1182/bloodadvances.2018gs112714