Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Dawn D. Parker"'
Autor:
Eric P. Gillis, Kyle Parcella, Michael Bowsher, James H. Cook, Christiana Iwuagwu, B. Narasimhulu Naidu, Manoj Patel, Kevin Peese, Haichang Huang, Lourdes Valera, Chunfu Wang, Kasia Kieltyka, Dawn D. Parker, Jean Simmermacher, Eric Arnoult, Robert T. Nolte, Liping Wang, John A. Bender, David B. Frennesson, Mark Saulnier, Alan Xiangdong Wang, Nicholas A. Meanwell, Makonen Belema, Umesh Hanumegowda, Susan Jenkins, Mark Krystal, John F. Kadow, Mark Cockett, Robert Fridell
Publikováno v:
Journal of Medicinal Chemistry. 66:1941-1954
Autor:
Kyle Parcella, Tao Wang, Kyle Eastman, Zhongxing Zhang, Zhiwei Yin, Manoj Patel, Yong Tu, Barbara Zhizhen Zheng, Michael A. Walker, Mark G. Saulnier, David Frennesson, Michael Bowsher, Eric Gillis, Kevin Peese, Makonen Belema, Christopher Cianci, Ira B. Dicker, Brian McAuliffe, Bo Ding, Paul Falk, Jean Simmermacher, Dawn D. Parker, Prasanna Sivaprakasam, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Susan Jenkins, John F. Kadow, Mark Krystal, Nicholas A. Meanwell, B. Narasimhulu Naidu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Allosteric HIV-1 integrase inhibitors (ALLINIs) have been of interest recently because of their novel mechanism of action. Strategic modifications to the C5 moiety of a class of 4-(4,4-dimethylpiperidinyl)-2,6-dimethylpyridinyl ALLI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef219ff3295f925d0de0c18dbd1bec7
https://europepmc.org/articles/PMC9190037/
https://europepmc.org/articles/PMC9190037/
Autor:
B. Narasimhulu Naidu, Manoj Patel, Brian McAuliffe, Bo Ding, Christopher Cianci, Jean Simmermacher, Susan Jenkins, Dawn D. Parker, Prasanna Sivaprakasam, Javed A. Khan, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Mark Krystal, Nicholas A. Meanwell, John F. Kadow
Publikováno v:
Journal of medicinal chemistry. 65(6)
Allosteric HIV-1 integrase inhibitors (ALLINIs) have garnered special interest because of their novel mechanism of action: they inhibit HIV-1 replication by promoting aberrant integrase multimerization, leading to the production of replication-defici
Autor:
Kyle Parcella, Manoj Patel, Yong Tu, Kyle Eastman, Kevin Peese, Eric Gillis, Makonen Belema, Ira B. Dicker, Brian McAuliffe, Bo Ding, Paul Falk, Jean Simmermacher, Dawn D. Parker, Prasanna Sivaprakasam, Javed A. Khan, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Susan Jenkins, John F. Kadow, Mark Krystal, Nicholas A. Meanwell, B. Narasimhulu Naidu
Publikováno v:
Bioorganic & Medicinal Chemistry. 67:116833
Allosteric integrase inhibitors (ALLINIs) of HIV-1 may hold promise as a novel mechanism for HIV therapeutics and cure. Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of ALLINIs provided a series of potent compo
Autor:
Anuradha Gupta, Ira B. Dicker, Mark Krystal, Tricia Protack, Jacob Swidorski, Yoganand Shanmugam, Susan Jenkins, Alicia Ng, Umesh Hanumegowda, Nicholas A. Meanwell, Dawn D. Parker, Alicia Regueiro-Ren, Brett R. Beno
Publikováno v:
Bioorganicmedicinal chemistry letters. 36
GSK3532795 (formerly BMS-955176) is a second-generation HIV-1 maturation inhibitor that has shown broad spectrum antiviral activity and preclinical PK predictive of once-daily dosing in humans. Although efficacy was confirmed in clinical trials, the
Autor:
B. Narasimhulu Naidu, Brian McAuliffe, Jean Simmermacher, Mark Krystal, Dawn D. Parker, Nicholas A. Meanwell, Manoj Patel, Christopher W. Allard, Linda Discotto, Beatrice Minassian, Susan Jenkins, Christopher Cianci
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(21)
The design, synthesis and structure–activity relationships associated with a series of C2-substituted pyrazolopyrimidines as potent allosteric inhibitors of HIV-1 integrase (ALLINIs) are described. Structural modifications to these molecules were m
Autor:
B. Narasimhulu Naidu, Dawn D. Parker, Helen Higley, Tricia Protack, Susan Jenkins, Manoj Patel, Zeyu Lin, Nicholas A. Meanwell, Brian Terry, Ira B. Dicker, Arvind Mathur, Chiradeep Panja, Michael A. Walker, Mark Krystal, Richard Rampulla
Publikováno v:
Bioorganicmedicinal chemistry. 28(13)
The design, synthesis and structure-activity relationships associated with a series of bridged tricyclic pyrimidinone carboxamides as potent inhibitors of HIV-1 integrase strand transfer are described. Structural modifications to these molecules were
Autor:
Alicia Regueiro-Ren, Jacob J. Swidorski, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Juliang Zhu, Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Brian Terry, Himadri Samanta, Sharon Zhang, Zhufang Li, John Easter, Brett R. Beno, Vinod Arora, Xiaohua S. Huang, Sandhya Rahematpura, Dawn D. Parker, Roy Haskell, Kenneth S. Santone, Mark I. Cockett, Mark Krystal, Nicholas A. Meanwell, Susan Jenkins, Umesh Hanumegowda, Ira B. Dicker
Publikováno v:
Journal of Medicinal Chemistry. 61:7289-7313
Autor:
Kathleen W. Mosure, Michele Matchett, Ronald J. Knox, Richard E. Olson, Joanne J. Bronson, Nicholas A. Meanwell, Matthew G. Soars, Linda J. Bristow, Ramkumar Rajamani, James Herrington, Amy Easton, Digavalli V. Sivarao, Dawn D. Parker, Rick L. Pieschl, Ping Chen, Guanglin Luo, Omar S. Barnaby, Lorin A. Thompson, Yong-Jin Wu, Andrea McClure, Jason M. Guernon, Amy Newton, Alicia Ng, Clotilde Bourin, Carolyn Diane Dzierba
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5490-5505
Since zwitterionic benzenesulfonamide Nav1.7 inhibitors suffer from poor membrane permeability, we sought to eliminate this characteristic by replacing the basic moiety with non-basic bicyclic acetals and monocyclic ethers. These efforts led to the d
Autor:
Dawn D. Parker, Karen Rigat, Kyle J. Eastman, Umesh Hanumegowda, Katharine A. Grant-Young, Nicholas A. Meanwell, Maria Tuttle, Tao Wang, Tatyana Zvyaga, Susan B. Roberts, Hua Fang, Kap-Sun Yeung, Mengping Liu, Julie A. Lemm, Kathy Mosure, Xiaoliang Zhuo, Maria Donoso, Kyle Parcella, Zhongxing Zhang, Matthew G. Soars, Zuzana Haarhoff, Zhiwei Yin, Ying-Kai Wang, John F. Kadow, Juliang Zhu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:771-774
Iterative structure–activity analyses in a class of highly functionalized furo[2,3-b]pyridines led to the identification of the second generation pan-genotypic hepatitis C virus NS5B polymerase primer grip inhibitor BMT-052 (14), a potential clinic