Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Dawn C, Newcomb"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Childhood asthma is a common chronic disease of the airways that results from host and environment interactions. Most risk factor studies of asthma point to the first year of life as a susceptibility window of mucosal exposure that directly impacts t
Externí odkaz:
https://doaj.org/article/164103da523e4907ba4bdb841651a5e7
Autor:
Tatiana Chirkova, Christian Rosas-Salazar, Tebeb Gebretsadik, Samadhan J. Jadhao, James D. Chappell, R. Stokes Peebles, William D. Dupont, Dawn C. Newcomb, Sergejs Berdnikovs, Peter J. Gergen, Tina V. Hartert, Larry J. Anderson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundIt is unknown whether RSV infection in infancy alters subsequent RSV immune responses.MethodsIn a nested cohort of healthy, term children, peripheral blood mononuclear cells (PBMCs) were collected at ages 2-3 years to examine RSV memory T c
Externí odkaz:
https://doaj.org/article/9621efd569df471b87ac7d0c1162d6c8
Autor:
Vivek D. Gandhi, Jacqueline-Yvonne Cephus, Allison E. Norlander, Nowrin U. Chowdhury, Jian Zhang, Zachary J. Ceneviva, Elie Tannous, Vasiliy V. Polosukhin, Nathan D. Putz, Nancy Wickersham, Amrit Singh, Lorraine B. Ware, Julie A. Bastarache, Ciara M. Shaver, Hong Wei Chu, R. Stokes Peebles Jr., Dawn C. Newcomb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Women have higher prevalence of asthma compared with men. In asthma, allergic airway inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and IL-13 production and eosinophil infiltration. Foxp3+ Tregs suppress an
Externí odkaz:
https://doaj.org/article/61b7abbe00a848c7a388570da40f9c5b
Autor:
Ozioma S. Chioma, Elizabeth Mallott, Binal Shah-Gandhi, ZaDarreyal Wiggins, Madison Langford, Andrew William Lancaster, Alexander Gelbard, Hongmei Wu, Joyce E. Johnson, Lisa Lancaster, Erin M. Wilfong, Leslie J. Crofford, Courtney G. Montgomery, Luc Van Kaer, Seth Bordenstein, Dawn C. Newcomb, Wonder Puryear Drake
Publikováno v:
Cells, Vol 12, Iss 5, p 766 (2023)
Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine ex
Externí odkaz:
https://doaj.org/article/2b5fde885bc54e49986452f6ae18e637
Publikováno v:
European Respiratory Review, Vol 30, Iss 162 (2021)
Asthma is a heterogenous disease, and its prevalence and severity are different in males versus females through various ages. As children, boys have an increased prevalence of asthma. As adults, women have an increased prevalence and severity of asth
Externí odkaz:
https://doaj.org/article/46034e0316fb45aeb33cee83f8d7bfeb
Autor:
Andrew R. Connelly, Brian M. Jeong, Mackenzie E. Coden, Jacob Y. Cao, Tatiana Chirkova, Christian Rosas-Salazar, Jacqueline-Yvonne Cephus, Larry J. Anderson, Dawn C. Newcomb, Tina V. Hartert, Sergejs Berdnikovs
Publikováno v:
Viruses, Vol 13, Iss 10, p 2055 (2021)
Respiratory syncytial virus (RSV) is a seasonal mucosal pathogen that infects the ciliated respiratory epithelium and results in the most severe morbidity in the first six months of life. RSV is a common cause of acute respiratory infection during in
Externí odkaz:
https://doaj.org/article/bd867079b8fd4af4a0ce806ad386aa21
Autor:
Jacqueline-Yvonne Cephus, Matthew T. Stier, Hubaida Fuseini, Jeffrey A. Yung, Shinji Toki, Melissa H. Bloodworth, Weisong Zhou, Kasia Goleniewska, Jian Zhang, Sarah L. Garon, Robert G. Hamilton, Vasiliy V. Poloshukin, Kelli L. Boyd, R. Stokes Peebles, Jr., Dawn C. Newcomb
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2487-2499 (2017)
Sex hormones regulate many autoimmune and inflammatory diseases, including asthma. As adults, asthma prevalence is 2-fold greater in women compared to men. The number of group 2 innate lymphoid cells (ILC2) is increased in patients with asthma, and w
Externí odkaz:
https://doaj.org/article/87fabe7a1e54432baf5024d79aed6767
Autor:
Hubaida Fuseini, Jacqueline-Yvonne Cephus, Pingsheng Wu, J. Brooke Davis, Diana C. Contreras, Vivek D. Gandhi, Jeffrey C. Rathmell, Dawn C. Newcomb
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Women have increased prevalence of Th17-mediated autoimmune diseases, including lupus and multiple sclerosis, and severe asthma. While estradiol and progesterone increased IL-17A production in Th17 cells by inhibiting Let7f miRNA expression and incre
Externí odkaz:
https://doaj.org/article/b11afdb0eb0744638f5561f950965701
Autor:
Sergey S. Gutor, Rodrigo I. Salinas, David S. Nichols, Julia M. R. Bazzano, Wei Han, Jason J. Gokey, Georgii Vasiukov, James D. West, Dawn C. Newcomb, Anna E. Dikalova, Bradley W. Richmond, Sergey I. Dikalov, Timothy S. Blackwell, Vasiliy V. Polosukhin
Publikováno v:
bioRxiv
Soldiers deployed to Iraq and Afghanistan have a higher prevalence of respiratory symptoms than non-deployed military personnel and some have been shown to have a constellation of findings on lung biopsy termed post-deployment respiratory syndrome (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40a846fd8dda9dd7802cb58e51ba0cf
https://europepmc.org/articles/PMC10245576/
https://europepmc.org/articles/PMC10245576/
Publikováno v:
Annals of Allergy, Asthma & Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9f2daa06d5c8ef5a5dd1b26af751ec
https://doi.org/10.1016/j.anai.2023.04.005
https://doi.org/10.1016/j.anai.2023.04.005