Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Dawn A. Thompson"'
Autor:
José F. Muñoz, Toni Delorey, Christopher B. Ford, Bi Yu Li, Dawn A. Thompson, Reeta P. Rao, Christina A. Cuomo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The outcomes of the interactions between individual host cells and pathogens are heterogeneous. Here, the authors assess transcriptional variability in both host and pathogen during infection of macrophages with the fungus Candida albicans, using sor
Externí odkaz:
https://doaj.org/article/ed4108988c524bcc93a97e3410c423b9
Autor:
Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha
Publikováno v:
eLife, Vol 5 (2016)
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration. How these lesions give rise to diverse pathology is not well unde
Externí odkaz:
https://doaj.org/article/1254815d1cd6435b9008238e7c48a98f
Autor:
Eeshit Dhaval Vaishnav, Carl G. de Boer, Jennifer Molinet, Moran Yassour, Lin Fan, Xian Adiconis, Dawn A. Thompson, Joshua Z. Levin, Francisco A. Cubillos, Aviv Regev
Publikováno v:
Nature
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal phenotype, and fitness(1–3). Constructing complete fitness landscapes, mapping DNA sequences to fitness, is a long-standing goal in biology, but has remained elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ea93b65ce66690e906e9166ff1581c
https://europepmc.org/articles/PMC8934302/
https://europepmc.org/articles/PMC8934302/
Autor:
Christopher B Ford, Jason M Funt, Darren Abbey, Luca Issi, Candace Guiducci, Diego A Martinez, Toni Delorey, Bi yu Li, Theodore C White, Christina Cuomo, Reeta P Rao, Judith Berman, Dawn A Thompson, Aviv Regev
Publikováno v:
eLife, Vol 4 (2015)
Candida albicans is both a member of the healthy human microbiome and a major pathogen in immunocompromised individuals. Infections are typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance. Studies in cl
Externí odkaz:
https://doaj.org/article/24a30f36045c4e68b7ec1778825dc6ed
Autor:
Eeshit Dhaval Vaishnav, Carl G. de Boer, Moran Yassour, Jennifer Molinet, Lin Fan, Xian Adiconis, Dawn A. Thompson, Francisco A. Cubillos, Joshua Z. Levin, Aviv Regev
Mutations in non-coding cis-regulatory DNA sequences can alter gene expression, organismal phenotype, and fitness. Fitness landscapes, which map DNA sequence to organismal fitness, are a long-standing goal in biology, but have remained elusive becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e12dca381dbff8110d549bacfc72cdbf
https://doi.org/10.1101/2021.02.17.430503
https://doi.org/10.1101/2021.02.17.430503
Autor:
Dawn A Thompson, Sushmita Roy, Michelle Chan, Mark P Styczynski, Jenna Pfiffner, Courtney French, Amanda Socha, Anne Thielke, Sara Napolitano, Paul Muller, Manolis Kellis, Jay H Konieczka, Ilan Wapinski, Aviv Regev
Publikováno v:
eLife, Vol 2 (2013)
Externí odkaz:
https://doaj.org/article/6af4fc673c904cc0a0ec5bd29202ae3a
Autor:
Dawn A Thompson, Sushmita Roy, Michelle Chan, Mark P Styczynsky, Jenna Pfiffner, Courtney French, Amanda Socha, Anne Thielke, Sara Napolitano, Paul Muller, Manolis Kellis, Jay H Konieczka, Ilan Wapinski, Aviv Regev
Publikováno v:
eLife, Vol 2 (2013)
Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along
Externí odkaz:
https://doaj.org/article/6c41a8412cae4405bcabcd5acc8a0273
Autor:
Reeta P. Rao, Dawn A. Thompson, Toni Delorey, Luca Issi, Christina A. Cuomo, George W. Bell, Rhys A. Farrer, Kelly Pastor, Benjamin Landry
Publikováno v:
Genetics. 205:559-576
Almost all humans are colonized with Candida albicans. However, in immunocompromised individuals, this benign commensal organism becomes a serious, life-threatening pathogen. Here, we describe and analyze the regulatory networks that modulate innate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c201fc47f417cf8584a98e1faba1396c
https://doi.org/10.1534/genetics.116.195024
https://doi.org/10.1534/genetics.116.195024
Autor:
Christina A. Cuomo, Bi yu Li, Dawn A. Thompson, José F. Muñoz, Reeta P. Rao, Christopher B. Ford, Toni Delorey
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The outcome of fungal infections depends on interactions with innate immune cells. Within a population of macrophages encountering Candida albicans, there are distinct host-pathogen trajectories; however, little is known about the molecular heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc65e1fddd3f944b724e9eebffbc27d
http://europepmc.org/articles/PMC6453965
http://europepmc.org/articles/PMC6453965
Autor:
Anna Lipzen, Sean P. Gilmore, Igor V. Grigoriev, Dawn A. Thompson, Michelle A. O’Malley, John K. Henske, Kevin V. Solomon
Publikováno v:
Fungal genetics and biology : FGB. 121
Early-diverging anaerobic fungi (order: Neocallimastigomycota), lignocelluolytic chytrid-like fungi central to fiber degradation in the digestive tracts of large herbivores, are attractive sources of cellulases and hemicellulases for biotechnology. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62024230908495ac63a34e972e6b6b82
https://pubmed.ncbi.nlm.nih.gov/30223087
https://pubmed.ncbi.nlm.nih.gov/30223087