Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dawn A. Bradbury"'
Publikováno v:
The Scientific World Journal, Vol 1, Pp 105-105 (2001)
Externí odkaz:
https://doaj.org/article/80fa2477ccd548c8b76e93b8d1128fae
Publikováno v:
The Scientific World Journal, Vol 1, Pp 105-105 (2001)
The Scientific World Journal
The Scientific World Journal
INTRODUCTION. The measurement of ATP is a recognised method for determination of proliferation or the effect of toxic environments on the cell. More recently, the relationship between ATP and ADP has been shown to be an important factor in determinin
Autor:
Dawn A. Bradbury, Alan J. Knox, Amy M Sutcliffe, Lisa Corbett, Jamie A Patel, Deborah L. Clarke
Publikováno v:
British Journal of Pharmacology. 157:436-450
Background and purpose: Endothelin-1 (ET-1) is implicated in airway inflammation in asthma, but the mechanisms of its effects are poorly understood. We studied the effect of ET-1 on expression of the chemokine, monocyte chemotactic protein-1 (MCP-1),
Autor:
Amy M Sutcliffe, Andrew Clayton, Hala El-Haroun, Dawn A. Bradbury, Karl Deacon, Deborah L. Clarke, Alan J. Knox
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L553-L562
We have previously shown that interleukin (IL)-1β, transforming growth factor (TGF)-β1, or bradykinin (BK) impair cAMP generation in response to prostacyclin analogs in human pulmonary artery smooth muscle (PASM), suggesting that inflammation can i
Publikováno v:
FEBS Letters. 579:2551-2556
Here, we report that vascular endothelial growth factor (VEGF)-A secretion by human airway smooth muscle cells was increased by interleukin 1 beta (IL-1beta) and transforming growth factor beta (TGFbeta). IL-1beta and TGFbeta induced cyclo-oxygenase
Publikováno v:
Journal of Biological Chemistry. 278:49954-49964
Bradykinin (BK) is an important mediator in several inflammatory and vascular diseases that acts in part via induction of cyclooxygenase-2 (COX-2). The mechanisms involved in BK-mediated COX-2 induction are unclear. Here we characterized the transcri
Publikováno v:
Journal of Biological Chemistry. 278:29366-29375
Bradykinin (BK) is a potent neutrophil chemotractant, proinflammatory mediator, and angiogenic factor, which acts through G protein-coupled receptors (GPCRs). Here we studied the mechanisms involved in IL-8 generation by BK in human airway smooth mus
Autor:
Alan J. Knox, Y. M. Zhu, Robert Newton, Dawn A. Bradbury, Lisa Corbett, Linhua Pang, Joanne Stocks, Elaine Holland
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L717-L725
Prostanoids are major regulators of smooth muscle function that are generated by cyclooxygenase (COX). Here we hypothesized that cytokines and mediators that regulate the pulmonary circulation would alter COX expression and prostanoid generation in p
Autor:
Dawn A. Bradbury, Nigel H. Russell
Publikováno v:
British Journal of Haematology. 91:374-379
Expression of the bcl-2 oncoprotein by AML blasts has previously been demonstrated to be heterogenous with high levels of bcl-2 expression being associated with a low complete remission rate and poor survival. We have quantified bcl-2 expression in A
Autor:
Alan J. Knox, Dawn A. Bradbury, Amy M Sutcliffe, Lisa Corbett, Karl Deacon, Deborah L. Clarke
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 181(5)
The transcription factor NF-κB plays a pivotal role in regulating inflammatory gene expression. Its effects are optimized by various coactivators, including histone acetyltransferases (HATs) such as CREB-binding protein/p300 and p300/CBP-associated