Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dawn A. Adkin"'
Autor:
D Caron, Dawn A. Adkin, Abraham Rubinstein, E. Strauss, Ian R. Wilding, I. Landau, Adel Penhasi, C J Kenyon, E. I. Lerner
Publikováno v:
Pharmaceutical Research. 14:103-107
Purpose. The aim of the present study was to provide 'proof of concept' data in man for novel polysaccharide preparations designed for colonic drug delivery using gamma scintigraphy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::611b989e8980e25e8b7f52bb3c2fe67d
https://doi.org/10.1023/a:1012019820603
https://doi.org/10.1023/a:1012019820603
Autor:
Stanley S. Davis, Dawn A. Adkin, Paul D. Huckle, Robert A. Sparrow, Ian R. Wilding, Anthony J. Phillips
Publikováno v:
Pharmaceutical Research. 12:393-396
The aim of the present study was to investigate the effect that different concentrations of mannitol have on small intestinal transit, and whether any observed effect was concentration dependent. Eight, healthy male subjects each received 200ml of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0802c6cbda1142bf7f8838c2966b61b7
https://doi.org/10.1023/a:1016256619309
https://doi.org/10.1023/a:1016256619309
Autor:
Penny A. Gowland, Bashar Issa, Ian R. Wilding, Jonathon Hykin, Robin C. Spiller, Paul D. Huckle, Dawn A. Adkin, A. Freeman
Publikováno v:
Pharmaceutical Research. 12:1134-1139
Purpose. Assessment of fluid volumes and flow through the small intestine has in the past only been possible by means of invasive intubation studies on human volunteers. Intubation very likely disturbs gut motility and stimulates secretion. Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a6da1cbe45147c03478d7816c4785c
https://doi.org/10.1023/a:1016251624220
https://doi.org/10.1023/a:1016251624220
Publikováno v:
Journal of Controlled Release. 23:147-156
The gastrointestinal transit of single unit dosage forms (tablets) of different sizes (3 mm, 6 mm, 9 mm and 12 mm) was investigated in eight healthy male volunteers. The volunteers followed a strictly controlled diet containing 28 g dietary fibre (18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61baeeef18ababacaa80dec9f315041b
https://doi.org/10.1016/0168-3659(93)90040-c
https://doi.org/10.1016/0168-3659(93)90040-c
Publikováno v:
Journal of pharmaceutical sciences. 84(12)
The aim of the study was to investigate whether mannitol at amounts relevant to pharmaceutical formulations would alter the oral bioavailability of cimetidine, a drug primarily absorbed from the small bowel. Seven healthy male subjects each received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11bced14c23866c7630e1ee596795d3
https://pubmed.ncbi.nlm.nih.gov/8748321
https://pubmed.ncbi.nlm.nih.gov/8748321
Publikováno v:
British journal of clinical pharmacology. 39(4)
1. The effect of three iso-osmotic pharmaceutical excipient solutions on gastrointestinal transit were investigated in eight healthy male volunteers. Each subject received 200 ml radiolabelled purified water, or a 200 ml solution of sodium acid pyrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e06877d18707c2ce722c7892126a34e
https://pubmed.ncbi.nlm.nih.gov/7640144
https://pubmed.ncbi.nlm.nih.gov/7640144