Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Dawn, Shepherd"'
Autor:
Yuzhe Weng, Dawn Shepherd, Yi Liu, Nitya Krishnan, Brian D. Robertson, Nick Platt, Gerald Larrouy-Maumus, Frances M. Platt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Lipids shed by pathogenic mycobacteria have been shown to inhibit NPC1, a lysosomal membrane protein deficient in most cases of a rate inherited lysosomal storage disorder Niemann-Pick disease type C (NPC). Here, authors utilise lipid extracts from c
Externí odkaz:
https://doaj.org/article/e759a16f0ebe4d9e872a5202002ab985
Autor:
David A Smith, Elena-Raluca Nicoli, Oscar C W Chen, Alexandria Colaco, Stephan Siebel, Stephanie Newman, Dawn Shepherd, Nicole Y Farhat, Andrew E Armitage, Claire Smith, George Seligmann, Mylvaganam Jeyakumar, Alaa Abdul-Sada, Forbes D Porter, Hal Drakesmith, Frances M Platt, Nick Platt
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
Background: Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal storage disorder characterized by the accumulation of multiple lipids in the late endosome/lysosomal system and reduced acidic store calcium. The lysosomal system regula
Externí odkaz:
https://doaj.org/article/88e020958a694dd6970e032b17add1f9
Autor:
Antonino Puglisi, Noemi Bognanni, Graziella Vecchio, Ece Bayir, Peter van Oostrum, Dawn Shepherd, Frances Platt, Erik Reimhult
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 573 (2023)
Core–shell superparamagnetic iron oxide nanoparticles hold great promise as a theranostic platform in biological systems. Herein, we report the biological effect of multifunctional cyclodextrin-appended SPIONs (CySPION) in mutant Npc1-deficient CHO
Externí odkaz:
https://doaj.org/article/541d52a1e213425bb686f63949ef58b3
Autor:
Vincenzo Cerundolo, Eugene Shenderov, Matheswaran Kandasamy, Uzi Gileadi, Jili Chen, Dawn Shepherd, James Gibbs, Gennaro Prota, Jonathan D Silk, Jonathan W Yewdell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background NY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development. The mouse genome does not encode an NY-ESO-1 homolog there
Externí odkaz:
https://doaj.org/article/a24b481c56034796b4410d660f7ec87d
Autor:
Shernae A Woolley, Emily R Tsimnadis, Cor Lenghaus, Peter J Healy, Keith Walker, Anthony Morton, Mehar S Khatkar, Annette Elliott, Ecem Kaya, Clarisse Hoerner, David A Priestman, Dawn Shepherd, Frances M Platt, Ben T Porebski, Cali E Willet, Brendon A O'Rourke, Imke Tammen
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0257078 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0238697.].
Externí odkaz:
https://doaj.org/article/7e02244db0ca4f3aa3fa0a89c70620d9
Autor:
Shernae A Woolley, Emily R Tsimnadis, Cor Lenghaus, Peter J Healy, Keith Walker, Andrew Morton, Mehar S Khatkar, Annette Elliott, Ecem Kaya, Clarisse Hoerner, David A Priestman, Dawn Shepherd, Frances M Platt, Ben T Porebski, Cali E Willet, Brendon A O'Rourke, Imke Tammen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238697 (2020)
Niemann-Pick type C disease is a lysosomal storage disease affecting primarily the nervous system that results in premature death. Here we present the first report and investigation of Niemann-Pick type C disease in Australian Angus/Angus-cross calve
Externí odkaz:
https://doaj.org/article/d18352b2e1bf491591fb70f828cbeb8e
Autor:
Lauren J. Howson, Giorgio Napolitani, Dawn Shepherd, Hemza Ghadbane, Prathiba Kurupati, Lorena Preciado-Llanes, Margarida Rei, Hazel C. Dobinson, Malick M. Gibani, Karen Wei Weng Teng, Evan W. Newell, Natacha Veerapen, Gurdyal S. Besra, Andrew J. Pollard, Vincenzo Cerundolo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Most MAIT cell response to infection studies are of mice. Here the authors characterize MAIT cell population responses to Salmonella Paratyphi A infection of 25 human volunteers using TCR clonotype analysis and mass cytometry of pre-infection matched
Externí odkaz:
https://doaj.org/article/09df915b396f40bb884220ebcc1bf9b9
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
In vivo and in silico analyses of IDO and SLC1A5 expression in primary mouse and human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1178cf659a9e7515b420d5f3712fdc4b
https://doi.org/10.1158/0008-5472.22411224.v1
https://doi.org/10.1158/0008-5472.22411224.v1
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
Table S1. Oligonucleotides used for generation of CRISPR guide sequences targeting SLC1A5, ATF4 or LAT1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5dd43e0b07c2c9f7bc0db316789b63
https://doi.org/10.1158/0008-5472.22411215.v1
https://doi.org/10.1158/0008-5472.22411215.v1
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
Tryptophan degradation is an immune escape strategy shared by many tumors. However, cancer cells' compensatory mechanisms remain unclear. We demonstrate here that a shortage of tryptophan caused by expression of indoleamine 2,3-dioxygenase (IDO) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::207a83018c5a9b58be993ebaa230bb4a
https://doi.org/10.1158/0008-5472.c.6508182.v1
https://doi.org/10.1158/0008-5472.c.6508182.v1