Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation.

Autor: Journigan VB; Department of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, West Virginia 25755, United States.; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia 25755, United States., Alarcón-Alarcón D; IDiBE: Instituto de Investigación, Desarrollo e innovación en Biotecnología Sanitaria de Elche, Universitas Miguel Hernández, 03202 Elche, Spain., Feng Z; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States., Wang Y; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States., Liang T; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States., Dawley DC; Department of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, West Virginia 25755, United States., Amin ARMR; Department of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, West Virginia 25755, United States.; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia 25755, United States., Montano C; The School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States.; The Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona 85281, United States.; The Magnetic Resonance Research Center, Arizona State University, Tempe, Arizona 85287, United States., Van Horn WD; The School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States.; The Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona 85281, United States.; The Magnetic Resonance Research Center, Arizona State University, Tempe, Arizona 85287, United States., Xie XQ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States., Ferrer-Montiel A; IDiBE: Instituto de Investigación, Desarrollo e innovación en Biotecnología Sanitaria de Elche, Universitas Miguel Hernández, 03202 Elche, Spain., Fernández-Carvajal A; IDiBE: Instituto de Investigación, Desarrollo e innovación en Biotecnología Sanitaria de Elche, Universitas Miguel Hernández, 03202 Elche, Spain.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 31; Vol. 12 (5), pp. 758-767. Date of Electronic Publication: 2021 Mar 31 (Print Publication: 2021).