Epigenetic gene expression links heart failure to memory impairment

Autor: Md Rezaul Islam, Dawid Lbik, M Sadman Sakib, Raoul Maximilian Hofmann, Tea Berulava, Martí Jiménez Mausbach, Julia Cha, Maria Goldberg, Elerdashvili Vakhtang, Christian Schiffmann, Anke Zieseniss, Dörthe Magdalena Katschinski, Farahnaz Sananbenesi, Karl Toischer, Andre Fischer

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-17 (2021)

Abstract In current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ‐centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure p

Externí odkaz: https://doaj.org/article/0c6241e668074484bd148e282c2ebcad

Epigenetic gene expression links heart failure to memory impairment

Autor: Maria Goldberg, Elerdashvili Vakhtang, Andre Fischer, Julia Cha, Karl Toischer, Tea Berulava, Raoul Maximilian Hofmann, Farahnaz Sananbenesi, Anke Zieseniss, Marti Jimenez Mausbach, M. Sadman Sakib, Dawid Lbik, Rezaul Islam, Christian Schiffmann, Dörthe M. Katschinski

Publikováno v: EMBO molecular medicine 13(3), e11900 (2021). doi:10.15252/emmm.201911900
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)

In current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ‐centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030d32c5e570117f3f975a0096d94559

Epigenetic gene-expression links heart failure to memory impairment

Autor: Julia Cha, Tea Berulava, Christian Schiffmann, Andre Fischer, Elerdashvili Vakhtang, Dawid Lbik, Rezaul Islam, Raoul Maximilian Hofmann, Anke Zieseniss, Marti Jimenez Mausbach, M. Sadman Sakib, Karl Toischer, Farahnaz Sananbenesi, D. M. Katschinski

In current clinical practice care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04af97bb2d2dc4bda97fa4176718ebcd
https://doi.org/10.1101/2020.01.22.915637

1180Cardiomyocyte-specific deletion of Brd4 induces hypertrophic cardiomyopathy and suggests a novel function for the chromatin reader as co-repressor in the healthy heart

Autor: Belal A. Mohamed, Karl Toischer, Andre Fischer, Dawid Lbik, E Buchholz, Gerd Hasenfuss

Publikováno v: European Heart Journal. 40

Introduction There is increasing evidence that epigenetic mechanisms such as histone modifications integrate stress stimuli into cellular responses during pathogenesis of heart failure (HF). The chromatin readers of the Bromo- and extraterminal domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ae330bf004b10d3f78accfe11caee9a
https://doi.org/10.1093/eurheartj/ehz748.0022

CRISPLD1: a novel conserved target in the transition to human heart failure

Autor: Frederike Weber, Stefan Bonn, Karl Toischer, Katrin Streckfuss-Bömeke, Sara Khadjeh, Setare Torkieh, Belal A. Mohamed, Ramon O. Vidal, Lukas Cyganek, Malte Tiburcy, Dawid Lbik, Vanessa Hindmarsh, Gerd Hasenfuss

Publikováno v: Basic Research in Cardiology
Basic research in cardiology 115(3), 27 (2020). doi:10.1007/s00395-020-0784-4

Heart failure is a major health problem worldwide with a significant morbidity and mortality rate. Although studied extensively in animal models, data from patients at the compensated disease stage are lacking. We sampled myocardium biopsies from aor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f8f685d9c876f3d0e5fe45c0c6357b
https://pubmed.ncbi.nlm.nih.gov/32146539