Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dawid J. Kucharski"'
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1756 (2023)
An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine. The domino reaction involved oxazolidinone ring closure, deprotonation, and stereo
Externí odkaz:
https://doaj.org/article/27891585bf9845bd8c6d4161f5bb537e
Publikováno v:
Molecules, Vol 27, Iss 3, p 1003 (2022)
Late-stage modification of drug molecules is a fast method to introduce diversity into the already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine, and hydroxychloroquine have been synthesized, starting from the r
Externí odkaz:
https://doaj.org/article/b9b60535b478467fb81d8de13bfc9e61
Publikováno v:
The Journal of Organic Chemistry
Novel 1,2-diamines based on the mefloquine scaffold prepared in enantiomerically pure forms resemble 9-amino-Cinchona alkaloids. Most effectively, 11-aminomefloquine with an erythro configuration was obtained by conversion of 11-alcohol into azide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37e17af5113e577693f0343411a684d
https://doi.org/10.1021/acs.joc.1c01316
https://doi.org/10.1021/acs.joc.1c01316