Výsledky vyhledávání - "Daw Tsun Shih"

Abstract 343: A potent and selective cfms inhibitor EI-1071 inhibits CSF1R signaling and regulates the tumor-associated macrophages

Autor: Hung-Kai Chen, Li-Ming Lu, Chih-Lun Hsiao, Yin-Ping Wang, Chu-Bin Liao, Shao-Zheng Peng, Huey-Wen Hsiao, Jing-Yi Huang, Daw-Tsun Shih

Publikováno v: Cancer Research. 79:343-343

We have found that tumor-associated macrophages (TAMs) isolated from metastatic tumors displayed a predominant M2 phenotype. Preclinical studies show that M2-polarized TAMs forge an immunosuppressive microenvironment at metastatic niches to facilitat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2728a34487db39ee3911ceb8e2ce2e32
https://doi.org/10.1158/1538-7445.am2019-343

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Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: Optimization of drug-like properties and target independent parameters

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:4276-4280

A high throughput screening campaign identified aryl 1,4-diazepane compounds as potent and selective cannabinoid receptor 2 agonists as compared to cannabinoid receptor 1. This class of compounds suffered from poor drug-like parameters as well as low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a944fcd194fddad63c17f449e5277bf3
https://doi.org/10.1016/j.bmcl.2011.05.068

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1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability

Autor: Edward Walker, Doris Riether, Sabine Löbbe, Jenkins James Edward, Clemens Möller, Mark J. Gemkow, Dan Albaugh, Lifen Wu, Michael B. Fisher, Daw-Tsun Shih, Angela Berry, Achim Sauer, Beatriz Noya-Marino, Heather Grbic, Monika Ermann, David S. Thomson, Claudia Albrecht, Pier F. Cirillo, Kathy O’Shea

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:2011-2016

A high-throughput screening campaign has identified 1,4-diazepane compounds which are potent Cannabinoid receptor 2 agonists with excellent selectivity against the Cannabinoid receptor 1. This class of compounds suffered from low metabolic stability.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d7df6ea42df00b701d6e848440cefc
https://doi.org/10.1016/j.bmcl.2011.02.017

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Morpholine containing CB2 selective agonists

Autor: Angela Berry, David S. Thomson, Doris Riether, Sabine Löbbe, Todd Bosanac, Andreas Ebneth, Diane Thome, Ernest L. Raymond, Daw-Tsun Shih, Renee Zindell, Mark J. Gemkow

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:1604-1609

Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f7d483f36825c54620336853737fe4
https://doi.org/10.1016/j.bmcl.2009.02.033

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Vitreous-induced Modulation of Integrins in Retinal Pigment Epithelial Cells: Effects of Fibroblast Growth Factor-2

Autor: Daw-tsun Shih, Daniela Meitinger, Richard C. Hunt, Jonathan C. Fox, D. Margaret Hunt

Publikováno v: Experimental Eye Research. 73:681-692

Growth in the presence of vitreous results in transformation of human RPE cells from an epithelioid to a fibroblast-like appearance and leads to an elevation of the expression of alpha(5) and alpha(2) integrins, while the level of alpha(3) integrin i

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https://doi.org/10.1006/exer.2001.1079

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A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function

Autor: Daw-tsun Shih, Joseph R. Woska, Takashi Kei Kishimoto, Terence A. Kelly, Viviany R. Taqueti, Nancy Hogg

Publikováno v: Journal of Leukocyte Biology. 70:329-334

Lymphocyte function-associated antigen(LFA)-1/intercellular adhesion molecule (ICAM)-1interactions mediate several important steps in the evolution of animmune response. LFA-1 is normally expressed in a quiescent state onthe surface of leukocytes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7300980767f8e1300087571e2db0f68e
https://doi.org/10.1189/jlb.70.2.329

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Adenoviral Gene Transfer of β3 Integrin Subunit Induces Conversion from Radial to Vertical Growth Phase in Primary Human Melanoma

Autor: Ju-Yu Hsu, Patricia Van Belle, David E. Elder, Friedegund Meier, Clayton A. Buck, Mei-Yu Hsu, Daw-Tsun Shih, Meenhard Herlyn

Publikováno v: The American Journal of Pathology. 153:1435-1442

Expression of the β3 subunit of the αvβ3 vitronectin receptor on melanoma cells is associated with tumor thickness and the ability to invade and metastasize. To address the role of αvβ3 in the complex process of progression from the nontumorigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bb535345bafd15ba9cffda0f09414d
https://doi.org/10.1016/s0002-9440(10)65730-6

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Cardiac Integrins

Autor: Louis Terracio, William Burgess, David G. Simpson, Thomas K. Borg, Daw Tsun Shih, Titus A. Reaves

Publikováno v: Cardiovascular Pathology. 7:135-143

An elaborate series of morphogenetic events must be precisely coordinated during development to promote the formation of the elaborate three-dimensional structure of the normal heart. In this study we focus on discussing how interconnections between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a8e03f33fa7d276836b72ec4e372c38
https://doi.org/10.1016/s1054-8807(97)00123-3

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EGF-R dependent regulation of keratinocyte survival

Autor: Ulrich Rodeck, Robert M. Lavker, Donald L. Ewert, Daw Tsun Shih, Csaba Kari, Pamela J. Jensen, Monika Jost

Publikováno v: Journal of Cell Science. 110:113-121

Tissue organization and maintenance within multicellular organisms is in part dependent on the ability of cells to undergo programmed cell death or apoptosis. Conversely, disruption of cell death pathways often is associated with tumor development. A

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https://doi.org/10.1242/jcs.110.2.113

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Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement

Autor: Neil Moss, Racheline Schwartz, Erick R. R. Young, Michael J. Burke, Eugene R. Hickey, Matthew R. Netherton, Raj Nagaraja, Yancey David Ward, Alexander Heim-Riether, Kathleen Haverty, Derek Cogan, Daw-Tsun Shih, Philip D. Ramsden, Qing Zhang, Gao Donghong A, Zhaoming Xiong, Kathy O’Shea

Publikováno v: Bioorganicmedicinal chemistry letters. 22(23)

This paper details exploration of a class of triazole-based cathepsin S inhibitors originally reported by Ellman and co-workers. SAR studies involving modifications across the whole inhibitor provide a perspective on the strengths and weaknesses of t

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https://pubmed.ncbi.nlm.nih.gov/23084902

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