Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Davy Guan"'
Publikováno v:
Current Research in Toxicology, Vol 7, Iss , Pp 100183- (2024)
Quantitative Structure Activity Relationship modelling methodologies need to incorporate relevant mechanistic information to have high predictive performance and validity. Electrophilic reactivity is a common mechanistic feature of skin sensitization
Externí odkaz:
https://doaj.org/article/e6727aa740534b5094cca59946fa8c14
Publikováno v:
Data in Brief, Vol 17, Iss , Pp 876-884 (2018)
Five datasets were constructed from ligand and bioassay result data from the literature. These datasets include bioassay results from the Ames mutagenicity assay, Greenscreen GADD-45a-GFP assay, Syrian Hamster Embryo (SHE) assay, and 2 year rat carci
Externí odkaz:
https://doaj.org/article/09e180eeb9114a62ad74acad51840de5
Autor:
José L. Medina-Franco, Edgar López-López, Emma Andrade, Lena Ruiz-Azuara, Angelo Frei, Davy Guan, Johannes Zuegg, Mark A.T. Blaskovich
Publikováno v:
Drug Discovery Today. 27:1420-1430
Metallodrug discovery has evolved in recent years, yielding several compounds in the clinic for therapeutic and medical imaging diagnostic applications. As reviewed here, several research groups in well-established medicinal inorganic chemistry group
Autor:
Davy Guan, Alexander Wade, Edwin G Tse, Alice Motion, Willem P. van Hoorn, Jonathan Cardoso-Silva, Adele M. Lehane, Giovanni Cincilla, Mario Öeren, Julia C. R. Lindblom, Mykola Galushka, Murray N. Robertson, Matthew H. Todd, James McCulloch, Slade Matthews, Mark G. Anderson, Benedict Irwin, Thomas M. Whitehead, Paul Willis, Laksh Aithani, Ho Leung Ng, Gareth Conduit, Vasileios A. Tatsis, Vito Spadavecchio, Raymond Lui, Kiaran Kirk, Irene Hallyburton
Publikováno v:
Journal of medicinal chemistry. 64(22)
The discovery of new antimalarial medicines with novel mechanisms of action is key to combating the problem of increasing resistance to our frontline treatments. The Open Source Malaria (OSM) consortium has been developing compounds ("Series 4") that
Publikováno v:
Journal of computer-aided molecular design. 34(5)
Effective representation of a molecule is required to develop useful quantitative structure-property relationships (QSPR) for accurate prediction of chemical properties. The octanol-water partition coefficient logP, a measure of lipophilicity, is an
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 94
In vitro genotoxicity bioassays are cost-efficient methods of assessing potential carcinogens. However, many genotoxicity bioassays are inappropriate for detecting chemicals eliciting non-genotoxic mechanisms, such as tumour promotion, this necessita
Autor:
Lui, Raymond1 (AUTHOR), Guan, Davy1 (AUTHOR), Matthews, Slade1 (AUTHOR) slade.matthews@sydney.edu.au
Publikováno v:
Journal of Computer-Aided Molecular Design. May2020, Vol. 34 Issue 5, p523-534. 12p.
Autor:
Guan, Davy1 (AUTHOR), Lui, Raymond1 (AUTHOR), Matthews, Slade1 (AUTHOR) slade.matthews@sydney.edu.au
Publikováno v:
Journal of Computer-Aided Molecular Design. May2020, Vol. 34 Issue 5, p511-522. 12p.
Publikováno v:
ACM International Conference Proceeding Series; 12/19/2019, p1-9, 9p