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Akademický článek

A transcriptome atlas of leg muscles from healthy human volunteers reveals molecular and cellular signatures associated with muscle location

Autor: Tooba Abbassi-Daloii, Salma el Abdellaoui, Lenard M Voortman, Thom TJ Veeger, Davy Cats, Hailiang Mei, Duncan E Meuffels, Ewoud van Arkel, Peter AC 't Hoen, Hermien E Kan, Vered Raz

Publikováno v: eLife, Vol 12 (2023)

Skeletal muscles support the stability and mobility of the skeleton but differ in biomechanical properties and physiological functions. The intrinsic factors that regulate muscle-specific characteristics are poorly understood. To study these, we cons

Externí odkaz: https://doaj.org/article/4dc181b8898c4adb85d653eb8a7d16f2

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Akademický článek

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Autor: Shadi Darvish Shafighi, Szymon M. Kiełbasa, Julieta Sepúlveda-Yáñez, Ramin Monajemi, Davy Cats, Hailiang Mei, Roberta Menafra, Susan Kloet, Hendrik Veelken, Cornelis A.M. van Bergen, Ewa Szczurek

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to

Externí odkaz: https://doaj.org/article/3d2fdb3a359f473fa50be1499b8e526d

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Akademický článek

A comparison of automatic cell identification methods for single-cell RNA sequencing data

Autor: Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz

Publikováno v: Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)

Abstract Background Single-cell transcriptomics is rapidly advancing our understanding of the cellular composition of complex tissues and organisms. A major limitation in most analysis pipelines is the reliance on manual annotations to determine cell

Externí odkaz: https://doaj.org/article/6fa424d324d04db09a2487f1aab95260

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Akademický článek

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma

Autor: Armando N. Bastidas Torres, Davy Cats, Jacoba J. Out-Luiting, Daniele Fanoni, Hailiang Mei, Luigia Venegoni, Rein Willemze, Maarten H. Vermeer, Emilio Berti, Cornelis P. Tensen

Publikováno v: Haematologica, Vol 107, Iss 3 (2021)

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of ge

Externí odkaz: https://doaj.org/article/0329258aee024b59b90918c65373cba9

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Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants

Autor: Marcella van Hoolwerff, Margo Tuerlings, Imke J L Wijnen, H Eka D Suchiman, Davy Cats, Hailiang Mei, Rob G H H Nelissen, Henrike M J van der Linden–van der Zwaag, Yolande F M Ramos, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt

Publikováno v: Rheumatology, 62(2), 894-904. OXFORD UNIV PRESS

Objective To identify FN1 transcripts associated with OA pathophysiology and investigate the downstream effects of modulating FN1 expression and relative transcript ratio. Methods FN1 transcriptomic data was obtained from our previously assessed RNA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5f0031df9e69548ac25b05c9ce40a2
https://doi.org/10.1093/rheumatology/keac272

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Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma

Autor: Rein Willemze, Hailiang Mei, Armando N. Bastidas Torres, Maarten H. Vermeer, Luigia Venegoni, Davy Cats, Daniele Fanoni, Jacoba J. Out-Luiting, Cornelis P. Tensen, Emilio Berti

Publikováno v: Haematologica. 107:702-714

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1733e6785de5786384e4d1e91aa5bda3
https://doi.org/10.3324/haematol.2020.274506

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Whole‐genome analysis uncovers recurrent IKZF1 inactivation and aberrant cell adhesion in blastic plasmacytoid dendritic cell neoplasm

Autor: A.N. Bastidas Torres, Davy Cats, Maarten H. Vermeer, Jessica Gliozzo, Emilio Berti, Roelof Willemze, Cornelis P. Tensen, Hailang Mei, Daniele Fanoni, Laura Corti, Marco Paulli

Publikováno v: Genes, Chromosomes & Cancer
Genes, Chromosomes and Cancer, 59(5), 295-308. WILEY

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematological malignancy with a poorly understood pathobiology and no effective therapeutic options. Despite a few recurrent genetic defects (eg, single nucleotide c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bb6a0857adaf18ad56cf9897b38a31
http://europepmc.org/articles/PMC7079160

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Improved Sezary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sezary syndrome

Autor: Maarten H. Vermeer, Safa Najidh, Cristina Teodosio, Jacoba J. Out-Luijting, Thomas B. Kuipers, Alberto Orfao, Jacques J.M. van Dongen, Cornelis P. Tensen, Willem H. Zoutman, Davy Cats, Alita J. van der Sluijs-Gelling, Julia Almeida, Thorbald van Hall, Hailiang Mei

Publikováno v: Blood, 138(24), 2539-2554. AMER SOC HEMATOLOGY
Digital.CSIC. Repositorio Institucional del CSIC
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Sézary syndrome (SS) is an aggressive leukemic form of cutaneous T-cell lymphoma with neoplastic CD4+ T cells present in skin, lymph nodes, and blood. Despite advances in therapy, prognosis remains poor, with a 5-year overall survival of 30%. The im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54267e1e52c7c374bb062c5c07818a68
https://doi.org/10.1182/blood.2021012286

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