Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Davorka Messmer"'
Autor:
Vegard Tjomsland, Anna Spångeus, Johanna Välilä, Per Sandström, Kurt Borch, Henrik Druid, Sture Falkmer, Ursula Falkmer, Davorka Messmer, Marie Larsson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 8, Pp 664-675 (2011)
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) is dynamic, with an extensive interaction between the stroma and tumor cells. The aim of this study was to delineate the cross talk between PDAC and cancer-associated fibroblasts (
Externí odkaz:
https://doaj.org/article/c18effce14234386bb0abbcbc4992248
Autor:
Vegard Tjomsland, Linda Bojmar, Per Sandström, Charlotte Bratthäll, Davorka Messmer, Anna Spångeus, Marie Larsson
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70874 (2013)
The interplay between the tumor cells and the surrounding stroma creates inflammation, which promotes tumor growth and spread. The inflammation is a hallmark for pancreatic adenocarcinoma (PDAC) and is to high extent driven by IL-1α. IL-1α is expre
Externí odkaz:
https://doaj.org/article/cefad28bbcc640f58f5cd4306bee443f
Autor:
Vegard Tjomsland, Lina Niklasson, Per Sandström, Kurt Borch, Henrik Druid, Charlotte Bratthäll, Davorka Messmer, Marie Larsson, Anna Spångeus
Publikováno v:
Clinical and Developmental Immunology, Vol 2011 (2011)
Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplas
Externí odkaz:
https://doaj.org/article/cf549a3d90264983bb6adf555b9512f5
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13441 (2010)
Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality. Functional impairment of DCs in p
Externí odkaz:
https://doaj.org/article/61b46c05889c4795823682f20b83ee23
Autor:
Morgan O'Hayre, Catherina L Salanga, Thomas J Kipps, Davorka Messmer, Pieter C Dorrestein, Tracy M Handel
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11716 (2010)
Chronic Lymphocytic Leukemia (CLL) pathogenesis has been linked to the prolonged survival and/or apoptotic resistance of leukemic B cells in vivo, and is thought to be due to enhanced survival signaling responses to environmental factors that protect
Externí odkaz:
https://doaj.org/article/508fadf06de44a06af218d26e2036b35
Autor:
Kim Fischer, Bryan Laffitte, Jason D. Jacintho, Christopher Baccei, Catherine Lee, Karin J. Stebbins, Alex R. Broadhead, Davorka Messmer, Lucia Correa, Daniel S. Lorrain, Peppi Prasit, Austin Chen, Nicholas Simon Stock, Yalda Bravo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:503-508
We previously published on the design and synthesis of novel, potent and selective PPARα antagonists suitable for either i.p. or oral in vivo administration for the potential treatment of cancer. Described herein is SAR for a subsequent program, whe
Autor:
Jason D. Jacintho, Yalda Bravo, Lucia Correa, Xiao-Jie Yan, Davorka Messmer, Karin J. Stebbins, Geraldine Cabrera, Nicholas Simon Stock, Daniel S. Lorrain, Austin Chen, Nicholas Chiorazzi, Kymmy Lorrain, David Spaner, Peppi Prasit
Publikováno v:
Molecular Medicine. 21:410-419
Tumor-specific metabolic changes can reveal new therapeutic targets. Our findings implicate a supporting role for fatty acid metabolism in chronic lymphocytic leukemia (CLL) cell survival. Peroxisome proliferator–activated receptor (PPAR)-α, a maj
Autor:
Brian E. Cathers, Diahnn Futalan, Bing Cui, Antonia Lopez-Girona, Jessie-F. Fecteau, Ila Sri Bharati, Thomas J. Kipps, Maria Schwaederle, Laura G. Corral, Svetlana Gaidarova, Emanuela M. Ghia, Davorka Messmer
Publikováno v:
Blood. 124:1637-1644
Lenalidomide has demonstrated clinical activity in patients with chronic lymphocytic leukemia (CLL), even though it is not cytotoxic for primary CLL cells in vitro. We examined the direct effect of lenalidomide on CLL-cell proliferation induced by CD
Autor:
Jason D. Jacintho, Richard Bundey, Nicholas Simon Stock, Alex R. Broadhead, Karin J. Stebbins, Austin Chen, Ryan C. Clark, Lucia Correa, Yalda Bravo, Christopher Baccei, Peppi Prasit, Davorka Messmer, Daniel S. Lorrain
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2267-2272
The discovery and SAR of a novel series of potent and selective PPARα antagonists are herein described. Exploration of replacements for the labile acyl sulfonamide linker led to a biaryl sulfonamide series of which compound 33 proved to be suitable
Autor:
Peppi Prasit, Daniel S. Lorrain, Davorka Messmer, Karin J. Stebbins, Lucia Correa, Austin Chen, Richard Bundey, Geraldine Cabrera, Alex R. Broadhead, Nicholas Simon Stock, Christopher Baccei, Yalda Bravo
Publikováno v:
European journal of pharmacology. 809
Peroxisome-proliferator activated receptors (PPAR) are members of the nuclear hormone receptor superfamily which regulate gene transcription. PPARα is a key regulator of lipid homeostasis and a negative regulator of inflammation. Under conditions of