Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Davor Slijepcevic"'
1
Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice
Autor: Reinout L.P. Roscam Abbing, Suzanne Duijst, Folkert Kuipers, Coen C. Paulusma, Rick Havinga, Joanne M. Donkers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf, Albert K. Groen, Davor Slijepcevic, Johan Kuiper
Publikováno v: Hepatology
Hepatology, 71(1), 247-258. Wiley
Hepatology, 71(1), 247-258
Hepatology (Baltimore, Md.)
Hepatology (Baltimore, Md.), 71(1), 247-258. John Wiley and Sons Ltd
Active secretion of bile salts into the canalicular lumen drives bile formation and promotes biliary cholesterol and phospholipid output. Disrupting hepatic bile salt uptake, by inhibition of sodium‐taurocholate cotransporting polypetide (NTCP; Slc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8925e3395df97e321cdbc1d9aae511
https://doi.org/10.1002/hep.30792
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2
Na+-taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice
Autor: Ulrich Beuers, Michael Trauner, Stan F.J. van de Graaf, Claudia D. Fuchs, Ronald P.J. Oude Elferink, Davor Slijepcevic, Reinout L.P. Roscam Abbing, Lizette C.M. Haazen
Publikováno v: Hepatology (Baltimore, Md.), 68(3), 1057-1069. John Wiley and Sons Ltd
Hepatology (Baltimore, Md.)
Accumulation of bile salts (BSs) during cholestasis leads to hepatic and biliary injury, driving inflammatory and fibrotic processes. The Na+ -Taurocholate Cotransporting Polypeptide (NTCP) is the major hepatic uptake transporter of BSs, and can be s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19764b487906eb11402302132ac74373
https://doi.org/10.1002/hep.29888
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3
Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice
Autor: Ulrich Beuers, Takeshi Katafuchi, Davor Slijepcevic, Reinout L.P. Roscam Abbing, Joanne M. Donkers, Jonathan H. M. van der Meer, Alfred H. Schinkel, Stéphanie van Hoppe, Ronald P.J. Oude Elferink, Manon E. Wildenberg, Stan F.J. van de Graaf, Dagmar Tolenaars, Antje Blank, Dirk R. de Waart
Publikováno v: Hepatology (Baltimore, Md.)
Hepatology (Baltimore, Md.), 66(5), 1631-1643. John Wiley and Sons Ltd
The Na+ -taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids. However, plasma bile acid levels are normal in a subset of NTCP knockout mice and in mice treated with myrcludex B,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddc97957feda7711cd00c28580a24c1
http://europepmc.org/articles/PMC5698707
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4
Bile Acid Uptake Transporters as Targets for Therapy
Autor: Davor Slijepcevic, Stan F.J. van de Graaf
Publikováno v: Digestive diseases (Basel, Switzerland), 35(3), 251-258. S. Karger AG
Background: Bile acids are potent signaling molecules that regulate glucose, lipid and energy homeostasis predominantly via the bile acid receptors farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor 5 (TGR5). The sodium taurochol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6f2de3b8c3e003800ed23412b0aa0b
https://doi.org/10.1159/000450983
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6
Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice
Autor: Christina Kaufman, Stan F.J. van de Graaf, Dirk R. de Waart, Davor Slijepcevic, Catharina G.K. Wichers, Ronald P.J. Oude Elferink, Bruno Stieger, Stephan Urban, Florian A. Lempp, Eduardo Hideo Gilglioni, Walter Mier, Ulrich Beuers, Suzanne Duijst
Publikováno v: Hepatology (Baltimore, Md.), 62(1), 207-219. John Wiley and Sons Ltd
Hepatology (Baltimore, Md.)
BASE-Bielefeld Academic Search Engine
The Na+-taurocholate cotransporting polypeptide (NTCP) mediates uptake of conjugated bile acids (BAs) and is localized at the basolateral membrane of hepatocytes. It has recently been recognized as the receptor mediating hepatocyte-specific entry of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f0350b12b02db21c53b73d5c508f59
https://doi.org/10.1002/hep.27694
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9
Galectin-4, a novel neuronal regulator of myelination
Autor: Anita Nomden, Wia Baron, Davor Slijepcevic, Michel J. Vos, Jenny C. de Jonge, Dick Hoekstra, Hans-J. Gabius, Arend H. Sikkema, Mirjana Stancic
Publikováno v: Glia; Vol 60
Glia, 60(6), 919-935. Wiley
Glia
Myelination of axons by oligodendrocytes (OLGs) is essential for proper saltatory nerve conduction, i.e., rapid transmission of nerve impulses. Among others, extracellular matrix (ECM) molecules, neuronal signaling, and axonal adhesion regulate the b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4bdc235b25eccfb59344bd2bd0b961
https://pubmed.ncbi.nlm.nih.gov/22431161
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