Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Davis Witt"'
Outcomes of Children With Low-Grade Gliomas in Low- and Middle-Income Countries: A Systematic Review
Autor:
Richard Ward, Hannah M. Jones, Davis Witt, Frederick Boop, Eric Bouffet, Carlos Rodriguez-Galindo, Ibrahim Qaddoumi, Daniel C. Moreira
Publikováno v:
JCO Global Oncology, Vol , Iss 8 (2022)
PURPOSEPediatric CNS tumors are increasingly a priority, particularly with the WHO designation of low-grade glioma (LGG) as one of six index childhood cancers. There are currently limited data on outcomes of pediatric patients with LGGs in low- and m
Externí odkaz:
https://doaj.org/article/ca59986f460e43b4826e40d03a65bfe5
Autor:
Natalie J. Serkova, Kenneth L. Jones, Davis Witt, Michael H. Handler, Kathleen Dorris, Bridget Sanford, Sana D. Karam, Andrew M. Donson, Andrea Griesinger, Etienne Danis, Rajeev Vibhakar, Todd C. Hankinson, Benjamin Van Court, Martin Sill, Jenna Steiner, Angela Pierce, Nicholas K. Foreman, Eric Prince, Ayman Oweida, Ahmed Gilani
Publikováno v:
Neuro-Oncology. 21:1540-1551
Background Treatment for pediatric posterior fossa group A (PFA) ependymoma with gain of chromosome 1q (1q+) has not improved over the past decade owing partially to lack of clinically relevant models. We described the first 2 1q+ PFA cell lines, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b55bf10a0be0b8df7523b4c66674812
https://doi.org/10.1093/neuonc/noz116
https://doi.org/10.1093/neuonc/noz116
Autor:
Richard C. E. Anderson, Davis Witt, Bette K. Kleinschmidt-DeMasters, Eric M. Jackson, Lia Gore, Todd C. Hankinson, Michael H. Handler, Juan Pedro Martinez-Barbera, Mark M. Souweidane, Andrea Griesinger, Thomas S. Jacques, John R. Apps, Vladimir Amani, Jose Mario Gonzalez-Meljem, Gerald A. Grant, Aik Choon Tan, Nicholas K. Foreman, Toba N. Niazi, James M. Johnston, Alex Virasami, Andrew M. Donson
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 76:779-788
Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fca342b739e484592aba556f1ad4bbd
https://doi.org/10.1093/jnen/nlx061
https://doi.org/10.1093/jnen/nlx061
Autor:
Rajeev Vibhakar, Eric Prince, Kathleen Dorris, Nicholas K. Foreman, Seth Lummus, Lindsey M. Hoffman, Vladimir Amani, Todd C. Hankinson, Andrea Griesinger, Andrew M. Donson, Michael H. Handler, Davis Witt
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 76:595-604
Ependymoma (EPN) is a common brain tumor of childhood that, despite standard surgery and radiation therapy, has a relapse rate of 50%. Clinical trials have been unsuccessful in improving outcome by addition of chemotherapy, and identification of nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6b0f1b3de8edd146e3413639c1b081
https://doi.org/10.1093/jnen/nlx040
https://doi.org/10.1093/jnen/nlx040
Autor:
Michael H. Handler, Ilango Balakrishnan, Nicholas K. Foreman, Kenneth L. Jones, Davis Witt, Randall Wong, Jean M. Mulcahy Levy, Bridget Sanford, John DeSisto, Rajeev Vibhakar, Sabrina R Georgio Westover, Sujatha Venkataraman, Lindsey M. Hoffman, Daniel C. Moreira, Andrew M. Donson, Sydney Grob, Andrea Griesinger
Publikováno v:
Neuro-Oncology. 19:1350-1360
Background Inflammation has been identified as a hallmark of high-risk Group A (GpA) ependymoma (EPN). Chronic interleukin (IL)-6 secretion from GpA tumors drives an immune suppressive phenotype by polarizing infiltrating monocytes. This study determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed266d9e744ce800fcb8a9490f0b662
https://doi.org/10.1093/neuonc/nox061
https://doi.org/10.1093/neuonc/nox061
Autor:
Vladimir Amani, Kathleen Dorris, Todd C. Hankinson, Nicholas K. Foreman, Davis Witt, Jean M. Mulcahy Levy, Michael H. Handler, Lindsey M. Hoffman, Andrew M. Donson, Andrea Griesinger, Rajeev Vibhakar, Elliot A. Warner
Children with ependymoma (EPN) are cured in less than 50% of cases, with little improvement in outcome over the last several decades. Chemotherapy has not affected survival in EPN, due in part to a lack of preclinical models that has precluded compre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fd494e21caefc51faf354908dc6272
https://europepmc.org/articles/PMC6125158/
https://europepmc.org/articles/PMC6125158/
EPEN-15. RETINOIDS AS POTENTIAL CHEMOTHERAPEUTIC OPTIONS FOR POSTERIOR FOSSA EPENDYMOMA OF CHILDHOOD
Autor:
Kathleen Dorris, Jean M. Mulcahy Levy, Lindsey Hoffman, Nicholas K. Foreman, Rajeev Vibhakar, Michael H. Handler, Andrew M. Donson, Todd C. Hankinson, Davis Witt, Andrea Griesinger, Vladimir Amani
Chemotherapy has yet to show reproducible therapeutic benefit in ependymoma, and this is partly due to a lack of models for preclinical testing. Treatment of ependymoma has changed little over the last 40 years and is essentially limited to surgery a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e6b10c7b9f37cf4e02b67e4bad724d
https://europepmc.org/articles/PMC6012085/
https://europepmc.org/articles/PMC6012085/
Autor:
Andrea Griesinger, Nicholas K. Foreman, Anandani Nellan, Vladimir Amani, Andrew M. Donson, Davis Witt
INTRODUCTION: Ependymoma (EPN) is a brain tumor that is chemotherapy insensitive. Surgery can remove grossly visible tumor in most EPN cases but, even when combined with radiation, there is a 10-year relapse rate of over 70%. Chimeric antigen recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0379db6fc55179fa7b67e024c8c21b
https://europepmc.org/articles/PMC6012536/
https://europepmc.org/articles/PMC6012536/
Autor:
Patrick Flannery, Andrew M. Donson, Andrea Griesinger, Angela Pierce, Adam L. Green, Rajeev Vibhakar, Nicholas K. Foreman, Todd C. Hankinson, Michael H. Handler, Kenneth L. Jones, Davis Witt, Katherine Gowan
Advances in ependymoma (EPN) treatment have been hampered due to lack of relevant in vitro and in vivo models. Our lab successfully generated patient derived posterior fossa group A (PFA) EPN cell lines. Our present goal is to establish patient deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33d41fc3b499ab5a3ceb5c9eec1ed53
https://europepmc.org/articles/PMC6012893/
https://europepmc.org/articles/PMC6012893/
Autor:
Sujatha Venkataraman, Davis Witt, Andrew M. Donson, Angela Pierce, Andrea Griesinger, Rajeev Vibhakar, Nicholas K. Foreman, Ilango Balakrishnan, Jessica Hansen, Vladimir Amani, Irina Alimova
Ependymoma (EPN) is the third most common pediatric central nervous system tumor, associated with poor survival and long-term morbidity. Posterior fossa Group A EPN (PFA) tumors are chemotherapy insensitive and often fatally recur. There is a critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff7229fd54f0804b1b5d4a76a49071b
https://europepmc.org/articles/PMC6012863/
https://europepmc.org/articles/PMC6012863/