Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Davis R Ingram"'
Autor:
Salah-Eddine Lamhamedi-Cherradi, Mayinuer Maitituoheti, Brian A. Menegaz, Sandhya Krishnan, Amelia M. Vetter, Pamela Camacho, Chia-Chin Wu, Hannah C. Beird, Robert W. Porter, Davis R. Ingram, Vandhana Ramamoorthy, Sana Mohiuddin, David McCall, Danh D. Truong, Branko Cuglievan, P. Andrew Futreal, Alejandra Ruiz Velasco, Nazanin Esmaeili Anvar, Budi Utama, Mark Titus, Alexander J. Lazar, Wei-Lien Wang, Cristian Rodriguez-Aguayo, Ravin Ratan, J. Andrew Livingston, Kunal Rai, A. Robert MacLeod, Najat C. Daw, Andrea Hayes-Jordan, Joseph A. Ludwig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Androgen receptor can promote tumour progression in desmoplastic small round cell tumour (DSRCT), an aggressive paediatric malignancy that predominantly affects young males. Here, the authors show that DSRCT is an AR-driven malignancy and sensitive t
Externí odkaz:
https://doaj.org/article/cfcacf91444e4871813d824beaa46a7e
Autor:
Rossana Lazcano, Carmelia M. Barreto, Ruth Salazar, Fernando Carapeto, Raymond S. Traweek, Cheuk H. Leung, Swati Gite, Jay Mehta, Davis R. Ingram, Khalida M. Wani, Kim-Anh T. Vu, Edwin R. Parra, Wei Lu, Jianling Zhou, Russell G. Witt, Brandon Cope, Prapassorn Thirasastr, Heather Y. Lin, Christopher P. Scally, Anthony P. Conley, Ravin Ratan, J. Andrew Livingston, Alexandra M. Zarzour, Joseph Ludwig, Dejka Araujo, Vinod Ravi, Shreyaskumar Patel, Robert Benjamin, Jennifer Wargo, Ignacio I. Wistuba, Neeta Somaiah, Christina L. Roland, Emily Z. Keung, Luisa Solis, Wei-Lien Wang, Alexander J. Lazar, Elise F. Nassif
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionUndifferentiated pleomorphic sarcoma (UPS) can be associated with a relatively dense immune infiltration. Immune checkpoint inhibitors (anti-PD1, anti-PDL1, and anti-CTLA4) are effective in 20% of UPS patients. We characterize the immune
Externí odkaz:
https://doaj.org/article/0f3178fc4ae44b07859cc53a24e0f97e
Autor:
Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108293- (2020)
Summary: Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused poole
Externí odkaz:
https://doaj.org/article/c36af48cd2dc464096d008d1f2795abf
Autor:
Tuyen Duong Thanh Nguyen, Yan Wang, Tuyen N. Bui, Rossana Lazcano, Davis R. Ingram, Min Yi, Varshini Vakulabharanam, Linjie Luo, Marc A. Pina, Cansu Karakas, Mi Li, Nicole M. Kettner, Neeta Somaiah, Peter J. Hougton, Osama Mawlawi, Alexander J. Lazar, Kelly K. Hunt, Khandan Keyomarsi
Publikováno v:
Cancer Research. 83:939-955
Treatment strategies with a strong scientific rationale based on specific biomarkers are needed to improve outcomes in patients with advanced sarcomas. Suppression of cell-cycle progression through reactivation of the tumor suppressor retinoblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310d412e75b4f5d29b1e206b671d388c
https://doi.org/10.1158/0008-5472.can-22-2258
https://doi.org/10.1158/0008-5472.can-22-2258
Publikováno v:
Human Pathology. 130:88-94
Synovial sarcoma is an aggressive translocation-associated soft tissue tumor driven by an SS18-SSX fusion oncoprotein. TRPS1 is a recently identified marker for breast carcinoma, but less is known about its expression in other tumor types. We encount
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3513044a1f0529146b97ebf4fdce51b9
https://doi.org/10.1016/j.humpath.2022.09.006
https://doi.org/10.1016/j.humpath.2022.09.006
Autor:
Yanshuo Chu, Enyu Dai, Yating Li, Guangchun Han, Guangsheng Pei, Davis R. Ingram, Krupa Thakkar, Jiang-Jiang Qin, Minghao Dang, Xiuning Le, Can Hu, Qing Deng, Ansam Sinjab, Pravesh Gupta, Ruiping Wang, Dapeng Hao, Fuduan Peng, Xinmiao Yan, Yunhe Liu, Shumei Song, Shaojun Zhang, John V. Heymach, Alexandre Reuben, Yasir Y. Elamin, Melissa P. Pizzi, Yang Lu, Rossana Lazcano, Jian Hu, Mingyao Li, Michael Curran, Andrew Futreal, Anirban Maitra, Amir A. Jazaeri, Jaffer A. Ajani, Charles Swanton, Xiang-Dong Cheng, Hussein A. Abbas, Maura Gillison, Krishna Bhat, Alexander J. Lazar, Michael Green, Kevin Litchfield, Humam Kadara, Cassian Yee, Linghua Wang
Publikováno v:
Nature Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed429f8acbfbc472cf403b177e12b01d
https://doi.org/10.1038/s41591-023-02371-y
https://doi.org/10.1038/s41591-023-02371-y
Autor:
Eric R, Molina, Letitia K, Chim, Salah-Eddine, Lamhamedi-Cherradi, Sana, Mohiuddin, David, McCall, Branko, Cuglievan, Sandhya, Krishnan, Robert W, Porter, Davis R, Ingram, Wei-Lien, Wang, Alexander J, Lazar, David W, Scott, Danh D, Truong, Najat C, Daw, Joseph A, Ludwig, Antonios G, Mikos
Publikováno v:
Oncotarget. 13:521-533
Osteosarcoma (OS) is a genetically diverse bone cancer that lacks a consistent targetable mutation. Recent studies suggest the IGF/PI3K/mTOR pathway and YAP/TAZ paralogs regulate cell fate and proliferation in response to biomechanical cues within th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42de9557008b4a4fe4f4c71efa3bc898
https://doi.org/10.18632/oncotarget.28215
https://doi.org/10.18632/oncotarget.28215
Autor:
David G. Kirsch, Alexander J. Lazar, Diana M. Cardona, Keila E. Torres, Davis R. Ingram, Yan Ma, Lixia Luo, William C. Eward, Wesley Huang, Tess Overton, Chang-Lung Lee, Rebecca D. Dodd
Haploinsufficiency in the tumor suppressor NF1 contributes to the pathobiology of neurofibromatosis type 1, but a related role has not been established in malignant peripheral nerve sheath tumors (MPNST) where NF1 mutations also occur. Patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311815f0c331bf0aed4ec116a033c987
https://doi.org/10.1158/0008-5472.c.6509162
https://doi.org/10.1158/0008-5472.c.6509162
Autor:
Khandan Keyomarsi, Kelly K. Hunt, Alexander J. Lazar, Osama Mawlawi, Peter J. Hougton, Neeta Somaiah, Nicole M. Kettner, Mi Li, Cansu Karakas, Marc A. Pina, Linjie Luo, Varshini Vakulabharanam, Min Yi, Davis R. Ingram, Rossana Lazcano, Tuyen N. Bui, Yan Wang, Tuyen Duong Thanh Nguyen
This File contains all the supplemental figures and figure legends referred to in the main text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d779eda52d937f45bdf97f51ffdc5556
https://doi.org/10.1158/0008-5472.22433523.v1
https://doi.org/10.1158/0008-5472.22433523.v1
Autor:
Khandan Keyomarsi, Kelly K. Hunt, Alexander J. Lazar, Osama Mawlawi, Peter J. Hougton, Neeta Somaiah, Nicole M. Kettner, Mi Li, Cansu Karakas, Marc A. Pina, Linjie Luo, Varshini Vakulabharanam, Min Yi, Davis R. Ingram, Rossana Lazcano, Tuyen N. Bui, Yan Wang, Tuyen Duong Thanh Nguyen
This file contains the description of supplementary materials and methods that is referred to in the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281de86ae9c2845eed2bd6667625ec28
https://doi.org/10.1158/0008-5472.22433520.v1
https://doi.org/10.1158/0008-5472.22433520.v1