Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Davis H. Daiker"'
Autor:
Davis H. Daiker, Jonathan B. Ward, Shipp Bk, Schoenfeld Ha, Mary Treinen Moslen, Gisela Witz, Klimpel Gr
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 59:181-196
Potential additive effects of ethanol consumption, a common life-style factor, and low-level benzene exposure, a ubiquitous environmental pollutant, were investigated. Ethanol is a potent inducer of the cytochrome P-450 2E1 (CYP2E1) enzyme, which bio
Publikováno v:
International Journal of Toxicology. 18:327-335
Although the CD-1 mouse strain has been used to investigate the toxicity of numerous substrates of Cyp2e1, limited information is available about responses of this strain to ethanol, a potent and clinically relevant inducer of this cytochrome P450 is
Autor:
Davis H. Daiker, Walter E. Hoffmann, Chessley R. Atchison, Lance R. Pohl, Bryan K. Shipp, A. Brian West, Arun Balakumaran, Judith F. Aronson, Sally J. Hargus, Mary Treinen Moslen
Publikováno v:
Gastroenterology. 119(6)
Background & Aims: Enteropathy is a frequent complication of diclofenac and other nonsteroidal anti-inflammatory drugs, yet little is known about the underlying mechanism. One possibility is that reactive metabolites of diclofenac form adducts with e
Publikováno v:
Journal of Toxicology and Environmental Health. 48:439-440
Benzene is a known carcinogen and hematopoietic toxin in humans and experimental animals. The effect of acute, high-dose exposure to benzene on hepatic bioactivation and detoxication enzymes has been defined, while little is known about the effect of