Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.

Autor: Davis, Skylar E.¹ (AUTHOR), Cook, Anna K.¹ (AUTHOR), Hall, Justin A.¹ (AUTHOR), Voskobiynyk, Yuliya¹ (AUTHOR), Carullo, Nancy V.² (AUTHOR), Boyle, Nicholas R.¹ (AUTHOR), Hakim, Ahmad R.¹ (AUTHOR), Anderson, Kristian M.¹ (AUTHOR), Hobdy, Kierra P.¹ (AUTHOR), Pugh, Derian A.¹ (AUTHOR), Murchison, Charles F.^1,3 (AUTHOR), McMeekin, Laura J.⁴ (AUTHOR), Simmons, Micah^1,4 (AUTHOR), Margolies, Katherine A.⁴ (AUTHOR), Cowell, Rita M.^1,4 (AUTHOR), Nana, Alissa L.⁵ (AUTHOR), Spina, Salvatore⁵ (AUTHOR), Grinberg, Lea T.^5,6 (AUTHOR), Miller, Bruce L.⁵ (AUTHOR), Seeley, William W.^5,6 (AUTHOR)

Publikováno v: Acta Neuropathologica Communications. 4/28/2023, Vol. 11 Issue 1, p1-19. 19p.

Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients

Autor: Arrant, Andrew E, Davis, Skylar E, Vollmer, Rachael M, Murchison, Charles F, Mobley, James A, Nana, Alissa L, Spina, Salvatore, Grinberg, Lea T, Karydas, Anna M, Miller, Bruce L, Seeley, William W, Roberson, Erik D

Publikováno v: Annals of clinical and translational neurology, vol 7, iss 12

ObjectiveThe goal of this study was to investigate the effect of progranulin insufficiency on extracellular vesicles (EVs), a heterogeneous population of vesicles that may contribute to progression of neurodegenerative disease. Loss-of-function mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7b793b3f3f004b409dc2060340c29806
https://escholarship.org/uc/item/42d8r2pd

Similar lysosomal abnormalities in cortex of patients with sporadic FTLD‐TDP type A and patients with FTD‐GRN.

Autor: Davis, Skylar E., Cook, Anna K., Voskobiynyk, Yuliya, Carullo, Nancy VN, Hakim, Ahmad R., Anderson, Kristian M., Hobdy, Kierra P., Pugh, Derian A, Murchison, Charles F, McMeekin, Laura J., Simmons, Micah S., Cowell, Rita M., Li, Alissa Nana, Spina, Salvatore, Grinberg, Lea Tenenholz, Miller, Bruce L., Seeley, William W., Arrant, Andrew E.

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 3, Vol. 18 Issue 3, p1-2, 2p