Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Autor: Mallard, T. T., Linnér, R. K., Grotzinger, A. D., Sanchez-Roige, S., Seidlitz, J., Okbay, A., e Vlaming, R., Meddens, S. F. W., Bipolar Disorder Working Group of the PGC, Palmer, A. A., Davis, L. K., Tucker-Drob, E. M., Kendler, K. S., Keller, M. C., Koellinger, P. D., Harden, K. P., Gordon-Smith, Katherine, Perry, Amy, Jones, Lisa

Publikováno v: Cell Genomics, 2(6):100140
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities ', Cell Genomics, vol. 2, no. 6, 100140, pp. 1-19 . https://doi.org/10.1016/j.xgen.2022.100140
Cell Genomics, 2(6):100140. Cell Press
Cell Genomics, 2(6):100140, 1-19. Cell Press

A single dimension of general psychopathology, p , has been hypothesized to represent a general liability that spans multiple types of psychiatric disorders and non-clinical variation in psychiatric symptoms across the lifespan. We conducted genome-w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a112183890f89a7eb35a32447782831
https://doi.org/10.1016/j.xgen.2022.100140

Polygenic burden in focal and generalized epilepsies

Autor: Leu C., Stevelink R., Smith A. W., Goleva S. B., Kanai M., Ferguson L., Campbell C., Kamatani Y., Okada Y., Sisodiya S. M., Cavalleri G. L., Koeleman B. P. C., Lerche H., Jehi L., Davis L. K., Najm I. M., Palotie A., Daly M. J., Busch R. M., Lal D., Feng Y. -C. A., Howrigan D. P., Abbott L. E., Tashman K., Cerrato F., Churchhouse C., Gupta N., Neale B. M., Berkovic S. F., Goldstein D. B., Lowenstein D. H., Cossette P., Cotsapas C., De Jonghe P., Dixon-Salazar T., Guerrini R., Hakonarson H., Heinzen E. L., Helbig I., Kwan P., Marson A. G., Petrovski S., Kamalakaran S., Stewart R., Weckhuysen S., Depondt C., Dlugos D. J., Scheffer I. E., Striano P., Freyer C., Krause R., May P., McKenna K., Regan B. M., Bellows S. T., Bennett C. A., Johns E. M. C., Macdonald A., Shilling H., Burgess R., Weckhuysen D., Bahlo M., O'Brien T. J., Todaro M., Stamberger H., Andrade D. M., Sadoway T. R., Mo K., Krestel H., Gallati S., Papacostas S. S., Kousiappa I., Tanteles G. A., Sterbova K., Vlckova M., Sedlackova L., Lassuthova P., Klein K. M., Rosenow F., Reif P. S., Knake S., Kunz W. S., Zsurka G., Elger C. E., Bauer J., Rademacher M., Pendziwiat M., Muhle H., Rademacher A., Van Baalen A., Von Spiczak S., Stephani U., Afawi Z., Korczyn A. D., Kanaan M., Canavati C., Kurlemann G., Muller-Schluter K., Kluger G., Hausler M., Blatt I., Lemke J. R., Krey I., Weber Y. G., Wolking S., Becker F., Hengsbach C., Rau S., Maisch A. F., Steinhoff B. J., Schulze-Bonhage A., Schubert-Bast S., Schreiber H., Borggrafe I., Schankin C. J., Mayer T., Korinthenberg R., Brockmann K., Dennig D., Madeleyn R., Kalviainen R., Auvinen P., Saarela A., Linnankivi T., Lehesjoki A. -E., Rees M. I., Chung S. -K., Pickrell W. O., Powell R., Schneider N., Balestrini S., Zagaglia S., Braatz V., Johnson M. R., Auce P., Sills G. J., Baum L. W., Sham P. C., Cherny S. S., Lui C. H. T., Barisic N., Delanty N., Doherty C. P., Shukralla A., McCormack M., El-Naggar H., Canafoglia L., Franceschetti S., Castellotti B., Granata T., Zara F., Iacomino M., Madia F., Vari M. S., Mancardi M. M., Salpietro V., Bisulli F., Tinuper P., Licchetta L., Pippucci T., Stipa C., Muccioli L., Minardi R., Gambardella A., Labate A., Annesi G., Manna L., Gagliardi M., Parrini E., Mei D., Vetro A., Bianchini C., Montomoli M., Doccini V., Marini C., Suzuki T., Inoue Y., Yamakawa K., Birute T., Ruta M., Algirdas U., Ruta P., Jurgita G., Ruta S., Sadleir L. G., King C., Mountier E., Caglayan S. H., Arslan M., Yapici Z., Yis U., Topaloglu P., Kara B., Turkdogan D., Gundogdu-Eken A., Bebek N., Ugur-Iseri S., Baykan B., Salman B., Haryanyan G., Yucesan E., Kesim Y., Ozkara C., Sheidley B. R., Shain C., Poduri A., Buono R. J., Ferraro T. N., Sperling M. R., Lo W., Privitera M., French J. A., Schachter S., Kuzniecky R. I., Devinsky O., Hegde M., Khankhanian P., Helbig K. L., Ellis C. A., Spalletta G., Piras F., Gili T., Ciullo V.

Publikováno v: Brain
142 (2019): 3473–3481. doi:10.1093/brain/awz292
info:cnr-pdr/source/autori:Leu, Costin; Stevelink, Remi; Smith, Alexander W.; Goleva, Slavina B.; Kanai, Masahiro; Ferguson, Lisa; Campbell, Ciaran; Kamatani, Yoichiro; Okada, Yukinori; Sisodiya, Sanjay M.; Cavalleri, Gianpiero L.; Koeleman, Bobby P.C.; Lerche, Holger; Jehi, Lara; Davis, Lea K.; Najm, Imad M.; Palotie, Aarno; Daly, Mark J.; Busch, Robyn M.; Lal, Dennis; Feng, Yen Chen Anne; Howrigan, Daniel P.; Abbott, Liam E.; Tashman, Katherine; Cerrato, Felecia; Churchhouse, Claire; Gupta, Namrata; Neale, Benjamin M.; Berkovic, Samuel F.; Goldstein, David B.; Lowenstein, Daniel H.; Cossette, Patrick; Cotsapas, Chris; De Jonghe, Peter; Dixon-Salazar, Tracy; Guerrini, Renzo; Hakonarson, Hakon; Heinzen, Erin L.; Helbig, Ingo; Kwan, Patrick; Marson, Anthony G.; Petrovski, Slavé; Kamalakaran, Sitharthan; Stewart, Randy; Weckhuysen, Sarah; Depondt, Chantal; Dlugos, Dennis J.; Scheffer, Ingrid E.; Striano, Pasquale; Freyer, Catharine; Krause, Roland; May, Patrick; McKenna, Kevin; Regan, Brigid M.; Bellows, Susannah T.; Bennett, Caitlin A.; Johns, Esther M.C.; Macdonald, Alexandra; Shilling, Hannah; Burgess, Rosemary; Weckhuysen, Dorien; Bahlo, Melanie; O'Brien, Terence J.; Todaro, Marian; Stamberger, Hannah; Andrade, Danielle M.; Sadoway, Tara R.; Mo, Kelly; Krestel, Heinz; Gallati, Sabina; Papacostas, Savvas S.; Kousiappa, Ioanna; Tanteles, George A.; ?terbová, Katalin; Vlcková, Markéta; Sedlácková, Lucie; La??uthová, Petra; Klein, Karl Martin; Rosenow, Felix; Reif, Philipp S.; Knake, Susanne; Kunz, Wolfram S.; Zsurka, Gábor; Elger, Christian E.; Bauer, Jürgen; Rademacher, Michael; Pendziwiat, Manuela; Muhle, Hiltrud; Rademacher, Annika; Van Baalen, Andreas; Von Spiczak, Sarah; Stephani, Ulrich; Afawi, Zaid; Korczyn, Amos D.; Kanaan, Moien; Canavati, Christina; Kurlemann, Gerhard; Müller-Schlüter, Karen; Kluger, Gerhard; Häusler, Martin/titolo:Polygenic burden in focal and generalized epilepsies/doi:10.1093%2Fbrain%2Fawz292/rivista:Brain (Print)/anno:2019/pagina_da:3473/pagina_a:3481/intervallo_pagine:3473–3481/volume:142
Brain, Oxford : Oxford university press, 2019, vol. 142, no. 11, p. 3473-3481
Brain : a journal of neurology, 142(11), 3473. Oxford University Press

See Hansen and Møller (doi:10.1093/brain/awz318) for a scientific commentary on this article. Using polygenic risk scores from a genome-wide association study in generalized and focal epilepsy, Leu et al. reveal a significantly higher genetic burden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129fa8e77fb23e3aa43684d166282437
http://hdl.handle.net/11585/792965

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls – CORRIGENDUM

Autor: Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Agrawal, A., Børglum, A. D., Bulik, C. M., Daly, M. J., Davis, L. K., Demontis, D., Edenberg, H. J., Grove, J., Gelernter, J., Neale, B. M., Pardiñas, A. F., Stahl, E., Walters, J. T.R., Walters, R., Sullivan, P. F., Posthuma, D., Polderman, T. J.C.

Publikováno v: Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Agrawal, A, Børglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardiñas, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2019, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls-CORRIGENDUM ', Psychological Medicine, vol. 49, no. 2, pp. 351 . https://doi.org/10.1017/S0033291718002945
Psychological Medicine, 49(2). Cambridge University Press
Psychological Medicine
Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, Agrawal, A, Børglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardiñas, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2019, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls-CORRIGENDUM ', Psychological Medicine, vol. 49, no. 2, pp. 351 . https://doi.org/10.1017/S0033291718002945
Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Agrawal, A, Borglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardinãs, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2019, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls-CORRIGENDUM ', Psychological Medicine, vol. 49, no. 2, pp. 351-351 . https://doi.org/10.1017/S0033291718002945
Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Agrawal, A, Børglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardiñas, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2019, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls-CORRIGENDUM ' Psychological Medicine, vol. 49, no. 2, pp. 351-351 . https://doi.org/10.1017/S0033291718002945

Background Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3c587a380d9982dc49afab31adff69
https://doi.org/10.1017/s0033291718002945

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Use of death certificates for mesothelioma surveillance

Autor: Davis, L K, Martin, T R, Kligler, B

Data from the Massachusetts Cancer Registry and death certificates were linked for mesothelioma cases reported to the registry from 1982 through 1987 to determine the extent to which the cause of death information that is given on the death certifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71f9f8ffec566238e0b0b438dc74c3d5
https://europepmc.org/articles/PMC1403683/