Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Davina Wojtacha"'
Autor:
Nico van Rooijen, Owen J. Sansom, Stephen J. Wigmore, Simon T. Barry, Rachel V. Guest, Davina Wojtacha, Rachel A. Ridgway, Luke Boulter, Timothy J. Kendall, David H. Wilson, Andrew Robson, Kay Samuel, Stuart J. Forbes
Publikováno v:
Boulter, L, Guest, R V, Kendall, T J, Wilson, D H, Wojtacha, D, Robson, A J, Ridgway, R A, Samuel, K, Van Rooijen, N, Barry, S T, Wigmore, S J, Sansom, O J & Forbes, S J 2015, ' WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited ', Journal of Clinical Investigation, vol. 125, no. 3, pp. 1269–1285 . https://doi.org/10.1172/JCI76452
Journal of Clinical Investigation, 125(3), 1269-1285. The American Society for Clinical Investigation
Boulter, L, Guest, R V, Kendall, T J, Wilson, D H, Wojtacha, D, Robson, A J, Ridgway, R A, Samuel, K, van Rooijen, N, Barry, S T, Wigmore, S J, Sansom, O J & Forbes, S J 2015, ' WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited ', Journal of Clinical Investigation, vol. 125, no. 3, pp. 1269-1285 . https://doi.org/10.1172/JCI76452
Journal of Clinical Investigation, 125(3), 1269-1285. The American Society for Clinical Investigation
Boulter, L, Guest, R V, Kendall, T J, Wilson, D H, Wojtacha, D, Robson, A J, Ridgway, R A, Samuel, K, van Rooijen, N, Barry, S T, Wigmore, S J, Sansom, O J & Forbes, S J 2015, ' WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited ', Journal of Clinical Investigation, vol. 125, no. 3, pp. 1269-1285 . https://doi.org/10.1172/JCI76452
Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in the incidence of CC, little progress has been made toward the development of treatments for
Autor:
Luke Boulter, Tania Roskams, Mina Komuta, Sofia Ferreira Gonzalez, Owen J. Sansom, Rachel V. Guest, Stephen J. Wigmore, Davina Wojtacha, Andrew Robson, Wei-Yu Lu, Stuart J. Forbes, Timothy J. Kendall, Benjamin J. Dwyer, Sarah E. Minnis-Lyons, Tak-Yung Man, Alexander Raven, Jennifer P. Morton
Publikováno v:
Proceedings of the National academy of sciences of the United States of America, Vol. 113, no. 43, p. 12250-12255 (2016)
Guest, R V, Boulter, L, Dwyer, B J, Kendall, T J, Man, T, Minnis-Lyons, S E, Lu, W-Y, Robson, A J, Gonzalez, S F, Raven, A, Wojtacha, D, Morton, J P, Komuta, M, Roskams, T, Wigmore, S J, Sansom, O J & Forbes, S J 2016, ' Notch3 drives development and progression of cholangiocarcinoma ', Proceedings of the National Academy of Sciences, vol. 113, no. 43, pp. 12250-12255 . https://doi.org/10.1073/pnas.1600067113
Guest, R V, Boulter, L, Dwyer, B J, Kendall, T J, Man, T, Minnis-Lyons, S E, Lu, W-Y, Robson, A J, Gonzalez, S F, Raven, A, Wojtacha, D, Morton, J P, Komuta, M, Roskams, T, Wigmore, S J, Sansom, O J & Forbes, S J 2016, ' Notch3 drives development and progression of cholangiocarcinoma ', Proceedings of the National Academy of Sciences, vol. 113, no. 43, pp. 12250-12255 . https://doi.org/10.1073/pnas.1600067113
The prognosis of cholangiocarcinoma (CC) is dismal. Notch has been identified as a potential driver; forced exogenous overexpression of Notch1 in hepatocytes results in the formation of biliary tumors. In human disease, however, it is unknown which c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5481771dc25e07cd40aa00ea257daf9
https://hdl.handle.net/2078.1/180106
https://hdl.handle.net/2078.1/180106
Autor:
Deborah J. Gow, Stephen J. Wigmore, Jeffrey W. Pollard, James W. Dear, Catherine A. Hawley, Daniel J. Antoine, David A. Hume, Calum C. Bain, Benjamin Francis, Alison C. MacKinnon, Stuart J. Forbes, Tak Yung Man, B. Kevin Park, Benjamin M. Stutchfield, Kenneth J. Simpson, Davina Wojtacha, Michael J. Hughes, Luke Devey, A M Mowat, Stephen J. Jenkins
Publikováno v:
Stutchfield, B M, Antoine, D J, MacKinnon, A C, Gow, D J, Bain, C C, Hawley, C A, Hughes, M, Francis, B, Wojtacha, D, Man, T Y, Dear, J W, Devey, L R, Mowat, A, Pollard, J W, Park, B K, Jenkins, S J, Simpson, K J, Hume, D A, Wigmore, S J & Forbes, S J 2015, ' CSF1 Restores Innate Immunity Following Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure ', Gastroenterology, vol. 149, no. 7, pp. 1896-1909 . https://doi.org/10.1053/j.gastro.2015.08.053
Background & Aims: Liver regeneration requires functional liver macrophages, which provide an immune barrier that is compromised after liver injury. The numbers of liver macrophages are controlled by macrophage colony-stimulating factor (CSF1). We ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e93783624fbb5aa149b524698ca9fb2
https://hdl.handle.net/20.500.11820/61cdae5c-a992-4e2b-aead-f8addba44f0d
https://hdl.handle.net/20.500.11820/61cdae5c-a992-4e2b-aead-f8addba44f0d
Autor:
Stephen N. Hartland, Caroline Pope, Davina Wojtacha, Marielle Van Deemter, David A. Hume, Andrew Robson, Timothy T. Gordon-Walker, Stuart J. Forbes, James Thomas, John P. Iredale, Prakash Ramachandran
Publikováno v:
Hepatology. 53:2003-2015
Clinical studies of bone marrow (BM) cell therapy for liver cirrhosis are under way but the mechanisms of benefit remain undefined. Cells of the monocyte-macrophage lineage have key roles in the development and resolution of liver fibrosis. Therefore
Autor:
Owen J. Sansom, Alex Raven, Trevor Hay, Rachel V. Guest, Atsunori Tsuchiya, David C. Hay, Rachel A. Ridgway, Timothy J. Kendall, Alison C. MacKinnon, Michael Williams, Alan Richard Clarke, Alicia M. Cole, John P. Iredale, Wei-Yu Lu, Thomas G. Bird, Davina Wojtacha, Stuart J. Forbes, Tak Yung Man, Thomas Jamieson, Luke Boulter
Publikováno v:
Lu, W Y, Bird, T, Boulter, L, Cole, A, Hay, T, Ridgway, R A, Kendall, T, Jamieson, T, Hay, D, Iredale, J, Clarke, A R & Sansom, O J 2015, ' Hepatic progenitor cells of biliary origin with liver repopulation capacity ', Nature Cell Biology, vol. 17, no. 8, pp. 971-983 . https://doi.org/10.1038/ncb3203
Nature cell biology
Lu, W-Y, Bird, T G, Boulter, L, Tsuchiya, A, Cole, A M, Hay, T, Guest, R V, Wojtacha, D, Man, T Y, Mackinnon, A, Ridgway, R A, Kendall, T, Williams, M J, Jamieson, T, Raven, A, Hay, D C, Iredale, J P, Clarke, A R, Sansom, O J & Forbes, S J 2015, ' Hepatic progenitor cells of biliary origin with liver repopulation capacity ', Nature Cell Biology, vol. 17, no. 8, pp. 971-983 . https://doi.org/10.1038/ncb3203
Nature cell biology
Lu, W-Y, Bird, T G, Boulter, L, Tsuchiya, A, Cole, A M, Hay, T, Guest, R V, Wojtacha, D, Man, T Y, Mackinnon, A, Ridgway, R A, Kendall, T, Williams, M J, Jamieson, T, Raven, A, Hay, D C, Iredale, J P, Clarke, A R, Sansom, O J & Forbes, S J 2015, ' Hepatic progenitor cells of biliary origin with liver repopulation capacity ', Nature Cell Biology, vol. 17, no. 8, pp. 971-983 . https://doi.org/10.1038/ncb3203
Hepatocytes and cholangiocytes self-renew following liver injury. Following severe injury hepatocytes are increasingly senescent, but whether hepatic progenitor cells (HPCs) then contribute to liver regeneration is unclear. Here, we describe a mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223078b865668161a94f2a0be85348a3
https://research-information.bris.ac.uk/ws/files/197123996/Hepatic_progenitor...supplementary_info.pdf
https://research-information.bris.ac.uk/ws/files/197123996/Hepatic_progenitor...supplementary_info.pdf
Publikováno v:
Stem Cells. 25:10-18
Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this capacity is lost after differentiation, and hESCs are being widely investigated for applications in regenerative medicine. To engineer protection against the unintenti
Autor:
Alison C. MacKinnon, Jonathan Jung, Wei Chen Hsieh, John P. Iredale, Baukje Schotanus, Luke Boulter, Neil C. Henderson, David C. Hay, Kenneth J. Simpson, Wei-Yu Lu, Thomas G. Bird, Davina Wojtacha, Tariq Sethi, Stuart J. Forbes, Claire N. Medine
Publikováno v:
Hsieh, W-C, Mackinnon, A C, Lu, W Y, Jung, J, Boulter, L, Henderson, N C, Simpson, K J, Schotanus, B, Wojtacha, D, Bird, T G, Hay, D C, Medine, C, Sethi, T, Iredale, J P & Forbes, S J 2015, ' Galectin-3 regulates hepatic progenitor cell expansion during liver injury ', Hepatology . https://doi.org/10.1136/gutjnl-2013-306290
Objective: Following chronic liver injury or when hepatocyte proliferation is impaired, ductular reactions (DR) containing hepatic progenitor cells (HPC) appear in the periportal regions and can regenerate the liver parenchyma. HPCs exist in a niche
Autor:
John P. Iredale, Atsunori Tsuchiya, Tak-Yung Man, Davina Wojtacha, David C. Hay, Stuart J. Forbes, Luke Boulter, Wei-Yu Lu, Thomas G. Bird, Rachel V. Guest
Publikováno v:
Journal of Hepatology. 62:S464-S465
Autor:
Thomas G. Bird, John P. Iredale, Michael Williams, Davina Wojtacha, Stuart J. Forbes, Wei-Yu Lu, Adriana Gambardella, Jessica Taube, Owen J. Sansom, Rachel A. Ridgway, Sabrina Gordon-Keylock, Luke Boulter, James Thomas
Publikováno v:
Bird, T G, Lu, W-Y, Boulter, L, Gordon-Keylock, S, Ridgway, R A, Williams, M J, Taube, J, Thomas, J A, Wojtacha, D, Gambardella, A, Sansom, O J, Iredale, J P & Forbes, S J 2013, ' Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling ', Proceedings of the National Academy of Sciences, vol. 110, no. 16, pp. 6542-6547 . https://doi.org/10.1073/pnas.1302168110
Tissue progenitor cells are an attractive target for regenerative therapy. In various organs, bone marrow cell (BMC) therapy has shown promising preliminary results, but to date no definite mechanism has been demonstrated to account for the observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d53c78f2dffa8ead34e2d54aaad43d
https://www.pure.ed.ac.uk/ws/files/8079443/Bone_marrow_injection_stimulates_hepatic_ductular_reactions_in_the_absence_of_injury_via_macrophage_mediated_TWEAK_signaling.pdf
https://www.pure.ed.ac.uk/ws/files/8079443/Bone_marrow_injection_stimulates_hepatic_ductular_reactions_in_the_absence_of_injury_via_macrophage_mediated_TWEAK_signaling.pdf
Autor:
David J Thomson, Timothy S. Walsh, Davina Wojtacha, Stewart Fleming, Allan D. Cumming, D.A.S. Jenkins
Publikováno v:
Clinical Science. 87:5-11
1. We studied the distribution of human tissue kallikrein mRNA in normal and diseased kidney, using in situ hybridization, together with immunohistochemical localization of renal kallikrein protein. Materials studied were (a) normal tissue from kidne