Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Davina C. Angell"'
Autor:
William L. Thompson, Rab K. Prinjha, Rosario Luque-Martin, Inmaculada Rioja, Menno P.J. de Winther, Sharon G. Bernard, Mathias Kalxdorf, Charlotte A. Ashby, Jan Van den Bossche, Catriona Sharp, Palwinder K. Mander, Annette E. Neele, Wouter J. de Jonge, Davina C. Angell, H. Christian Eberl, Johannes Freudenberg
Publikováno v:
Luque-Martin, R, Angell, D C, Kalxdorf, M, Bernard, S, Thompson, W, Eberl, H C, Ashby, C, Freudenberg, J, Sharp, C, van den Bossche, J, de Jonge, W J, Rioja, I, Prinjha, R K, Neele, A E, de Winther, M P J & Mander, P K 2021, ' IFN-γ Drives human monocyte differentiation into highly proinflammatory macrophages that resemble a phenotype relevant to psoriasis ', Journal of Immunology, vol. 207, no. 2, pp. 555-568 . https://doi.org/10.4049/jimmunol.2001310
Journal of Immunology, 207(2), 555-568. American Association of Immunologists
Journal of immunology (Baltimore, Md., 207(2), 555-568. American Association of Immunologists
Journal of Immunology, 207(2), 555-568. American Association of Immunologists
Journal of immunology (Baltimore, Md., 207(2), 555-568. American Association of Immunologists
As key cells of the immune system, macrophages coordinate the activation and regulation of the immune response. Macrophages present a complex phenotype that can vary from homeostatic, proinflammatory, and profibrotic to anti-inflammatory phenotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc517f304ed2fe12bc5eeb2aa48c676
https://research.vumc.nl/en/publications/469e0fd3-afc0-42e4-9c7d-f61ecc14c6aa
https://research.vumc.nl/en/publications/469e0fd3-afc0-42e4-9c7d-f61ecc14c6aa
Autor:
Stephen John Atkinson, Chun-wa Chung, Peter Ernest Soden, Laurie J. Gordon, Rab K. Prinjha, Nicholas Smithers, Rebecca C. Furze, Kathryn A. Giblin, Davina C. Angell, Marcus Bantscheff, Nigel J. Parr, Inmaculada Rioja, Jason Witherington, Gerard Drewes
Publikováno v:
MedChemComm. 5:342-351
Herein we describe the design and synthesis of a dual active histone deacetylase (HDAC)/bromodomain and extra terminal (BET) small molecule tool inhibitor, DUAL946 (1). Exploiting our extensive epigenetic toolbox, we achieved the functionalisation of
Autor:
Deborah Needham, Jason A. Holt, Stuart N. Farrow, Robert J. H. Austin, Keith Biggadike, Karen Leavens, Iain Uings, Davina C. Angell, Michael V. Haase, Joyce Lesley Matthews
Publikováno v:
British Journal of Pharmacology. 169:1389-1403
Background and Purpose Glucocorticoids are highly effective therapies for a range of inflammatory diseases. Advances in the understanding of the diverse molecular mechanisms underpinning glucocorticoid action suggest that anti-inflammatory molecules
Autor:
Robert J. H. Austin, Christopher Patten, Eugene L. Stewart, Simon Taylor, Peter Brown, Christopher M. Yates, Davina C. Angell, Jason A. Holt, Rosemary Z. Sasse, Iain Uings, Ryan P. Trump, Jodi M. Maglich
Publikováno v:
Journal of Medicinal Chemistry. 53:4531-4544
Glucocorticoid receptor (GR) agonists have been used for more than half a century as the most effective treatment of acute and chronic inflammatory conditions despite serious side effects that accompany their extended use that include glucose intoler
Autor:
Diane M. Coe, David House, Hawa Diallo, Davina C. Angell, Heather A. Barnett, Steve Keeling, Iain M. McLay, Andy Craven, Simon J. F. Macdonald, Tony W. J. Cooper, Torquil I. Jack, Keith Biggadike, Simon Taylor, Samuel Oliver, Iain Uings, James Gray, Natalie Wellaway
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(4)
A novel series of indazole non-steroidal glucocorticoid receptor agonist has been discovered. This series features a sulfonamide central core and meta amides which interact with the extended ligand binding domain. This series has produced some of the