Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Davina, Owen"'
Autor:
Davina Owen, Kevin Gunn, Himanshu Naik, Francois Rugiero, Giuseppe Alvaro, Gerard M. P. Giblin, Dominique Derjean, David R Witty, Valerie Morisset, Simon Tate, David T. MacPherson, Charles Large, Christopher A Hinckley, Joanne Palmer
Publikováno v:
ACS Med Chem Lett
[Image: see text] Drugs that block voltage-gated sodium channels (Na(V)s) have utility in treating conditions including pain, epilepsy, and cardiac arrhythmias and as anesthetics (Lancet Neurol.2010941342420298965; Expert Opin. Ther. Pat.201020755779
Autor:
Catherine H, Gill, Andrew, Randall, Stewart A, Bates, Kerstin, Hill, Davina, Owen, Phil M, Larkman, William, Cairns, Shahnaz P, Yusaf, Paul R, Murdock, Paul J L M, Strijbos, Andrew J, Powell, Christopher D, Benham, Ceri H, Davies
Publikováno v:
British journal of pharmacology. 143(3)
The human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. Activation of this recombinan